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Studies Found: 1335

WHOLE BODY - FOOD POISONING

Hydrogen-Rich Water and Lactulose Protect Against Growth Suppression and Oxidative Stress in Female ...

Year Published: 2018

The objective of the current experiment was to evaluate whether hydrogen-rich water (HRW) or lactulose (LAC) could protect against the adverse effects of Fusarium mycotoxins-contaminated diet on the growth performance and antioxidant status in weaning piglets. A total of 24 individually housed female piglets were randomly assigned to receive four treatments for 25 days (six pigs/treatment): ...
LUNG - ASTHMA

Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic ...

Year Published: 2018

Background Asthma is a worldwide common chronic airway disease that cannot be cured and results in the huge burden in public health. Oxidative stress was considered an important mechanism in the pathogenesis of asthma. Hydrogen gas been demonstrated to function as a novel antioxidant and exert therapeutic antioxidant activity in a number of diseases and the function of this nontoxic gas in asthma ...
LIVER - SURGERY/TRANSPLANTATION

Effect of hydrogen-rich saline on apoptosis induced by hepatic ischemia reperfusion upon ...

Year Published: 2018

Hepatic ischemia reperfusion injury (HIRI) occurs commonly in liver surgery and liver transplantation. Hydrogen, a safe and effective antioxidant, exerts a protective effect against liver injury. In this study, we investigated the role of hydrogen-rich saline (HRS) in apoptosis in a miniature pig model of laparoscopic HIRI upon hepatectomy. Bama miniature pigs were randomly assigned to sham, I/R ...
SKIN - RADIOPROTECTION

Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells

Year Published: 2018

Chronic ultraviolet (UV) exposure-induced oxidative stress is associated with the pathogenesis of skin damage. However, the nuclear factor erythroid‑2‑related factor 2 (Nrf2) pathway is a critical factor in protecting cells against UVB‑induced injury through inhibiting oxidative stress. Furthermore, Nrf2 activation requires the involvement of the phosphoinositide-3 kinase (PI3K)/protein ...
LUNG - SURGERY/TRANSPLANTATION

The Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular ...

Year Published: 2018

Background: Lung ischemia-reperfusion injury (LIRI) remains an important factor for the early mortality of lung transplantations. Hydrogen (H2) can attenuate lung injury and improve lung function in animal experiments. In previous studies, pulmonary microvascular endothelial cells (PMVECs) were used to simulate LIRI. We hypothesized that H2 can alleviate inflammatory injury in a PMVECs lung ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway

Year Published: 2018

Background: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly ...
HEART - ATHEROSCLEROSIS

Hydrogen attenuated oxidized low‑density lipoprotein‑induced inflammation through the ...

Year Published: 2018

Chronic inflammation is a central pathogenic mechanism underlying the induction and progression of atherosclerosis (AS). Hydrogen has been demonstrated to serve a protective role in diverse models of disease. However, the potential effects and mechanism of hydrogen with respect to ox-LDL-induced inflammation have not yet been completely elucidated. In the present study, various concentrations (0, ...
WHOLE BODY - CANCER

Intratumoral high-payload delivery and acid-responsive release of H 2 for efficient cancer therapy ...

Year Published: 2018

Hydrogen gas therapy as an emerging and promising therapy strategy has overwhelming advantages especially in bio-safety compared with other gas therapy routes, but is facing a great challenge in the long-term, highly-concentrated, deeply-seated disease site-specific administration of hydrogen gas, owing to its low solubility, high but aimless diffusibility in vivo. Herein, we propose to construct ...
BRAIN - PARKINSON'S DISEASE

Randomized, double-blind, multicenter trial of hydrogen water for Parkinson’s disease: New ...

Year Published: 2018

Background: Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson’s Disease Rating Scale (UPDRS) score of Parkinson’s disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. Methods: Changes in the total UPDRS ...
EYE - UVEAL INJURY

Effects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats

Year Published: 2018

BACKGROUND Molecular hydrogen (H2) has been widely reported to have benefiicial effects in diverse animal models and human disease through reduction of oxidative stress and inflammation. The aim of this study was to investigate whether hydrogen gas could ameliorate endotoxin-induced uveitis (EIU) in rats. MATERIAL AND METHODS Male Sprague-Dawley rats were divided into a normal group, a model ...
BRAIN - STROKE

Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting ...

Year Published: 2018

Cerebral ischemia/reperfusion injury (IRI) is a serious complication during the treatment of stroke patients with very few effective clinical treatment. Hydrogen (H2) can protect mitochondria function and have favorable therapeutic effects on cerebral IRI. Mitophagy plays an important role in eliminating damaged or dysfunctional mitochondria and maintaining mitochondria homeostasis. However, ...
INTESTINE - CANCER

Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on ...

Year Published: 2018

Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality of cancer survivors and even shortens their lifespan. Hydrogen has been shown to protect against tissue injuries caused by oxidative stress and ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via ...

Year Published: 2018

Oxidative stress is regarded as a key regulator in the pathogenesis of prolonged hyperoxia-induced lung injury, which causes injury to alveolar epithelial cells and eventually leads to development of bronchopulmonary dysplasia (BPD). Many studies have shown that hydrogen has a protective effect in a variety of cells. However, the mechanisms by which hydrogen rescues cells from damage due to ...
EYE - RETINAL INJURY

Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ...

Year Published: 2018

Retinal ischemia/reperfusion injury (IRI) plays a crucial role in the pathophysiology of various ocular diseases. Our previous study have shown that postconditioning with inhaled hydrogen (H2) (HPC) can protect retinal ganglion cells (RGCs) in a rat model of retinal IRI. Our further study aims to investigate potential mechanisms underlying HPC-induced protection. Retinal IRI was performed on the ...
KIDNEY - ACUTE KIDNEY INJURY

Influences of hydrogen-rich saline on acute kidney injury in severely burned rats and mechanism

Year Published: 2018

Objective: To explore the influences of hydrogen-rich saline on acute kidney injury in severely burned rats and to analyze the related mechanism. Methods: Fifty-six Sprague Dawley rats were divided into sham injury group (n=8), burn group (n=24), and hydrogen-rich saline group (n=24) according to the random number table. Rats in sham injury group were treated by 20 ℃ water bath on the back for ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing ...

Year Published: 2018

Hydrogen gas (H2) exerts a beneficial effect against traumatic brain injury (TBI). microRNA-21 (miR-21) is one of the most highly expressed members of small non-coding microRNA family in mammalian cells. miR-21 can improve the neurological outcome after TBI. In the present study, we investigated whether H2 treatment could improve the neurological outcome after TBI via increasing miR-21 expression. ...
LUNG - CANCER

Hydrogen gas inhibits lung cancer progression through targeting SMC3

Year Published: 2018

Lung cancer is one of the most common lethal malignancies in the globe. The patients' prognoses are dim due to its high metastatic potential and drug resistance. Therefore, in the present study, we aim to find a more potent therapeutic approach for lung cancer. We mainly explored the function of hydrogen gas (H2) on cell viability, apoptosis, migration and invasion in lung cancer cell lines A549 ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-Rich Saline Activated Autophagy via HIF-1 α Pathways in Neuropathic Pain Model

Year Published: 2018

Background Neuropathic pain is a chronic and intractable pain, with very few effective analgesics. It involves an impaired cell autophagy process. Hydrogen-rich saline (HRS) reportedly reduces allodynia and hyperalgesia in a neuropathic pain model; however, it is unknown whether these effects involve autophagy induction. Methods We investigated the relationship between HRS and cell autophagy in a ...
SKIN - COSMETIC SKIN ISSUES

Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and ...

Year Published: 2018

Biomedical properties of hydrogen water have been extensively investigated, but the effect of hydrogen on good healthy subjects remains unclear. This study was designed to explore the hygiene improvement by electrolytically generated hydrogen warm water (40°C) on capillary blood streams, skin moisture, and keratin plugs in skin pores in normal good healthy subjects with their informed consents. ...
BRAIN - BRAIN INJURY

Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs

Year Published: 2018

Cyclooxygenase-2 (COX-2) has an established role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE). In this study we sought to determine whether COX-2 was induced by asphyxia in newborn pigs, and whether neuronal COX-2 levels were affected by H2 treatment. Piglets were subjected to either 8 min of asphyxia or a more severe 20 min of asphyxia followed by H2 treatment (inhaling room air ...
BONE - OSTEOARTHRITIS

In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by Magnesium Passivation/Activation ...

Year Published: 2018

Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H2) is known to have anti‐inflammatory effects; however, the bioavailability of directly administered H2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H2 at inflamed tissues is proposed. The delivery system comprises ...
LIVER - SURGERY/TRANSPLANTATION

Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against ...

Year Published: 2018

Cold storage (CS) remains the gold standard for organ preservation worldwide, although it is inevitably associated with ischemia/reperfusion injury (IRI). Molecular hydrogen (H2 ) is well known to have antioxidative properties. However, its unfavorable features, ie, inflammability, low solubility, and high tissue/substance permeability, have hampered its clinical application. To overcome such ...
INTESTINE - PARKINSON'S DISEASE

Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in ...

Year Published: 2018

Oral administration of hydrogen water ameliorates Parkinson's disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacteria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by ingestion of lactulose is low in PD patients. The decreased hydrogen production by intestinal ...
WHOLE BODY - EXCERCISE

Removal Effect of Hydrogen Water Drinking on Exercise-induced Production of Reactive Oxygen Species ...

Year Published: 2018

PURPOSE This study aimed to investigate whether hydrogen (H2) water drinking reduced oxidative damage products (8-hydroxy-2-deoxyguanosine [8-oxo-dG], malondialdehyde [MDA], L-lactate) produced in blood after exercise-induced oxidative stress. METHODS Men (n=7) and women (n=8) (systolic blood pressure [BP]: 90-150 mmHg, diastolic BP: 60-100 mmHg) were recruited. Exercise was performed for 20 ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt ...

Year Published: 2018

Myocardial ischemia, hypoxia and reperfusion injury are induced by aortic occlusion, cardiac arrest and resuscitation during cardiopulmonary bypass (CPB), which can severely affect cardiac function. The aim of the present study was to investigate the effects of hydrogen‑rich solution (HRS) and aquaporin (AQP) on cardiopulmonary bypass (CPB)‑induced myocardial injury, and determine the ...