Intratumoral high-payload delivery and acid-responsive release of H 2 for efficient cancer therapy using the ammonia borane-loaded mesoporous silica nanomedicine

Bao-Lian Su, Bin Zhao, Lihua Chen, Mingjian Fan, Penghe Zhao, Qianjun He, Tian Yang, Tianfu Wang, Zhaokui Jin, Zhihao Wang

Read more:

DOI: 10.1016/j.apmt.2018.01.008 DOI is the universal ID for this study.

This link will take you to the full study.


Hydrogen gas therapy as an emerging and promising therapy strategy has overwhelming advantages especially in bio-safety compared with other gas therapy routes, but is facing a great challenge in the long-term, highly-concentrated, deeply-seated disease site-specific administration of hydrogen gas, owing to its low solubility, high but aimless diffusibility in vivo. Herein, we propose to construct an ammonia borane-loaded mesoporous silica nanomedicine (AB@MSN) to realize the intratumoral high-payload delivery and in situ acid-controlled release of hydrogen gas. The constructed AB@MSN nanomedicine has a superhigh H2 loading capacity (130.6 mg/g, more than 1370 times higher than that of the traditional H2@liposome nanomedicine) and a highly acid-responsive sustained release behavior, exhibiting high anticancer efficacies and high bio-safety in vitro and in vivo. The proposed nanomedicine-based strategy opens a new window for precision high-efficacy hydrogen therapy.

Publish Year 2018
Country China
Rank Positive
Journal Applied Materials Today
Primary Topic Whole Body
Secondary TopicCancer
Model Cell Culture
Tertiary TopicNovel Therapy
Vehicle Gas (Sustained Release)
pH N/A
Application Implantation