Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota
Dan Luo, Hai-Chao Wang, Hui-Wen Xiao, Jia-Li Dong, Li-Xin Zhou, Ming Cui, Qi-Sheng Zheng, Sai-Jun Fan, Shu-Yi Zhao, Yuan Li
Read more:
DOI:
10.1038/emm.2017.246
DOI is the universal ID for this study.
This link will take you to the full study.
Abstract:
Although radiation therapy is a cornerstone of modern management of malignancies, various side effects are inevitably linked to abdominal and pelvic cancer after radiotherapy. Radiation-mediated gastrointestinal (GI) toxicity impairs the life quality of cancer survivors and even shortens their lifespan. Hydrogen has been shown to protect against tissue injuries caused by oxidative stress and excessive inflammation, but its effect on radiation-induced intestinal injury was previously unknown. In the present study, we found that oral gavage with hydrogen-water increased the survival rate and body weight of mice exposed to total abdominal irradiation (TAI); oral gavage with hydrogen-water was also associated with an improvement in GI tract function and the epithelial integrity of the small intestine. Mechanistically, microarray analysis revealed that hydrogen-water administration upregulated miR-1968-5p levels, thus resulting in parallel downregulation of MyD88 expression in the small intestine after TAI exposure. Additionally, high-throughput sequencing showed that hydrogen-water oral gavage resulted in retention of the TAI-shifted intestinal bacterial composition in mice. Collectively, our findings suggested that hydrogen-water might be used as a potential therapeutic to alleviate intestinal injury induced by radiotherapy for abdominal and pelvic cancer in preclinical settings.
| Publish Year |
2018 |
| Country |
China |
| Rank |
Positive |
| Journal |
Experimental and Molecular Medicine |
| Primary Topic |
Intestine |
| Secondary Topic | Cancer |
| Model |
Mouse |
| Tertiary Topic | Radioprotection |
| Vehicle |
Water (Dissolved) |
| pH |
Neutral |
| Application |
Gavage |
| Comparison |
|
| Complement |
|
Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults
2023 - Intestine - Obesity
Fecal short-chain fatty acids are responsive to oral hydrogen in overweight adults. Propionic acid significantly increased in participants who consumed hydrogen-rich water for 12 wk compared with those who consumed tap water. This finding holds ...
In vitro fermentation properties of magnesium hydride and related modulation effects on broiler ...
2023 - Intestine - Gut Microbiome
Magnesium hydride (MGH), a highly promising hydrogen-producing substance/additive for hydrogen production through its hydrolysis reaction, has the potential to enhance broiler production. However, before incorporating MGH as a hydrogen-producing ...
Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting ...
2023 - Intestine - Metabolic Syndrome
Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models. However, the potential benefits of H2 treatment ...
Hydrogen–oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with ...
Three patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12, 2, and 0.5 years after radiotherapy, respectively. The secretions subsided after conventional drug and drainage treatments, but hearing continued to ...
Investigating the Effect of Hydrogen-Rich Water on Liver Cell Injury and Liver Cancer by Regulating ...
Background Liver cancer is an extremely heterogeneous malignant disease among tumors identified to date. In recent years, a large number of studies have found that low-concentration hydrogen or hydrogen-rich water or hydrogen-saturated physiological ...
RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via ...
Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in DMEM medium with or without hydrogen. RNA sequencing was used to ...