search - Hydrogen Studies

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated ...

Year Published: 2018

Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) ...

BRAIN - TRAUMATIC BRAIN INJURY

Effect of hydrogen-rich water on the chondriosome damage and cytokines in brain tissue of rats with ...

Year Published: 2018

Objective: To observe the effect of hydrogen-rich water on the chondriosome damage and cytokines change in brain tissue of rats with traumatic brain injury (TBI). Methods: Fifty-four health male Sprague-Dawley (SD) rats were divided into three groups by random number table: sham group, trauma group (TBI group), and trauma+hydrogen-rich water group (TBI+HW group), the rats in each group were ...

MUSCLE - ATHEROSCLEROSIS

Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental ...

Year Published: 2018

Reactive oxygen species (ROS) impair neovascularization and perfusion recovery following limb ischemia in patients with peripheral arterial disease (PAD). Hydrogen molecules (H2) comprise an antioxidant gas that has been reported to neutralize cytotoxic ROS. The present study investigated whether H2 may serve as a novel therapeutic strategy for PAD. H2‑saturated water or dehydrogenized water was ...

STOMACH - GASTROESOPHAGEAL REFLUX DISEASE

Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of ...

Year Published: 2018

Gastroesophageal reflux disease (GERD), a clinical condition characterized by reflux of gastroduodenal contents in the oesophagus, has proved to demonstrate a strong link between oxidative stress and the development of GERD. Proton pump inhibitors (PPIs) have been universally accepted as first-line therapy for management of GERD. The potential benefits of electrolysed reduced water (ERW), rich in ...

HEART - HEART ATTACK

Early Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial ...

Year Published: 2018

It has been reported that hydrogen-rich saline (HRS) water reduces oxidative stress, and early aerobic exercise (eAE) acts an efficient exercise preconditioning (EP) against cardiac I/R injury. However, whether early aerobic exercise combined with hydrogen-rich saline (eAE-HRS) water can more effectively protect myocardial damage induced by acute myocardial infarction (MI) is still unknown. This ...

BREAST - CANCER

Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer ...

Year Published: 2018

Electrochemical reduced water (ERW) has been proposed to have beneficial effects on human health due to its rich content of H 2 and the presence of platinum nanoparticles with antioxidant effects. Many studies have demonstrated that ERW scavenging properties are able to reduce the damage caused by oxidative stress in different experimental models. Although few in vivo studies have been reported, ...

NOSE - RHINITIS

Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis

Year Published: 2018

Allergic rhinitis (AR) is a common chronic inflammatory condition. It has been previously indicated that oxidative stress may contribute to allergic inflammation, including AR. Although molecular hydrogen (H2), an antioxidative agent, has been effective in treatment of numerous oxidative stress-associated diseases, the effect of inhalation of a high concentration of H2 on AR remains unknown. In ...

SKIN - WOUND HEALING

Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of ...

Year Published: 2018

Pressure ulcer formation depends on various factors among which repetitive ischaemia/reperfusion(I/R) injury plays a vital role. Molecular hydrogen (H2 ) was reported to have protective effects on I/R injuries of various internal organs. In this study, we investigated the effects of H2 inhalation on pressure ulcer and the underlying mechanisms. H2 inhalation significantly reduced wound area, ...

LUNG - SEPSIS

Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of ...

Year Published: 2018

Background: Lungs are one of the most common target organs of sepsis [1]. Hydrogen gas (H2), which has selective anti-oxidative effects, can be effectively used to treat septic mice. Mitochondrial dysfunction and dynamics play important roles in sepsis-induced organ damage. Methods: By using cecal ligation and puncture (CLP), a classic septic model, we explored the role of 2% H2 treatment in ...

HEART - HIGH BLOOD PRESSURE

Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: ...

Year Published: 2018

Background: Molecular hydrogen has been shown to have antioxidant effect and have been used to prevent oxidative stress-related diseases. The goal of this study was to explore if hydrogen-rich saline (HRS) plays a cardioprotective effect on abdominal aortic constriction (AAC) induced cardiac hypertrophy in rats. 60adult Sprague-Dawley rats received surgically the AAC for 6-week. After the surgery, ...

WHOLE BODY - EXCERCISE

Alkaline water improves exercise-induced metabolic acidosis and enhances anaerobic exercise ...

Year Published: 2018

Hydration is one of the most significant issues for combat sports as athletes often use water restriction for quick weight loss before competition. It appears that alkaline water can be an effective alternative to sodium bicarbonate in preventing the effects of exercise-induced metabolic acidosis. Therefore, the main aim of the present study was to investigate, in a double blind, placebo ...

WHOLE BODY - EXCERCISE

Effects of hydrogen rich water on prolonged intermittent exercise

Year Published: 2018

Background: Recent studies showed a positive effect of Hydrogen Rich Water (HRW) intake on acid-basic homeostasis at rest. We investigated 2-weeks of HRW intake on repeated sprint performance and acid-base status during prolonged intermittent cycling exercise. Methods: In a cross over single-blind protocol, eight trained male cyclists (age [mean ± SD] 41±7 years, body mass 72.3±4.4 kg, height ...

HEART - HEART FAILURE

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative ...

Year Published: 2018

Background: Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H2) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of H2 inhalation in delaying the progress of CHF. Methods and Results: A total of 60 Sprague-Dawley (SD) rats ...

BRAIN - STROKE

Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model

Year Published: 2018

Objective: Hydrogen inhalation has been found to be neuroprotective and anti-oxidative in several brain injury models. Building on these studies, we investigated potential neuroprotective effects of hydrogen inhalation in a rat model of intracerebral hemorrhage (ICH), focusing on apoptosis and inflammation. Methods: Forty-five 8-week-old male Sprague-Dawley rats were randomly divided into three ...

KIDNEY - CANCER

Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and ...

Year Published: 2018

Background: Cisplatin is a potent chemotherapeutic drug for cancer therapy, but it has serious side effects in clinical treatment, particularly nephrotoxicity. The purpose of this study was to evaluate the protective effect of electrolyzed reduced water (ERW) on renal injury caused by cisplatin. Methods: Animals were divided into four groups as follows: normal control group, cisplatin control ...

LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production ...

Year Published: 2018

Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall thickening, infiltration by neutrophils, consolidation, alveolar hemorrhage, increased levels of inflammatory factors and recruitment of M1 macrophages. ...

SPINE - SPINAL CORD INJURY

Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by ...

Year Published: 2018

Background/aims: Hydrogen selectively neutralizes reactive oxygen species (ROS) and ameliorates various ROS-induced injuries. Spinal cord injury (SCI) is a serious injury to the central nervous system, and secondary SCI is closely related to excessive ROS generation. We hypothesized that hydrogen inhalation ameliorates SCI, and the mechanism of action may be related to the protective effects of ...

LIVER - SURGERY/TRANSPLANTATION

Influence of Hydrogen-rich Saline on Hepatocyte Autophagy During Laparoscopic Liver ...

Year Published: 2018

Introduction: The purpose of this study was to investigate the protective effect of hydrogen-rich saline (HRS) against liver ischaemia-reperfusion combined resection injury. Material and Methods: Eighteen miniature pigs were randomly divided into three groups: a sham operated group (sham group, laparoscopic liver ischaemia-reperfusion combined resection injury group (IRI group), and a ...

KIDNEY - CHRONIC KIDNEY DISEASE

Molecular Hydrogen Suppresses Renal Injury in Chronic Kidney Disease Rats

Year Published: 2018

Background: Cathode side commercial hydrogen dissolved water (HW) exhibits low dissolved oxygen, high dissolved hydrogen and significant negative redox potential. Therapeutic applications of HW have recently been reported. Thus, the present study aimed to examine effects of HW consumption on renal injury in a rat model of chronic kidney disease.Methods: Twenty Dahl S rats were given HW and tap ...

HEART - SURGERY/TRANSPLANTATION

Hydrogen‑rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via ...

Year Published: 2018

The incidence of complications and mortality following open-heart surgery with cardiopulmonary bypass (CPB) is associated with the severity of the myocardial injury that occurs during surgery. Hydrogen-rich solution (HRS) may prevent antioxidant stress and inhibit apoptosis and inflammation. The present study was designed to investigate the effects of HRS on CPB-induced myocardial injury, and to ...

WHOLE BODY - EXCERCISE

Hydrogen Water Drinking Exerts Antifatigue Effects in Chronic Forced Swimming Mice via Antioxidative ...

Year Published: 2018

Purpose: This study was performed to evaluate antifatigue effect of hydrogen water (HW) drinking in chronic forced exercise mice model. Materials and methods: Twelve-week-old C57BL6 female mice were divided into nonstressed normal control (NC) group and stressed group: (purified water/PW-treated group and HW-treated group). Stressed groups were supplied with PW and HW, respectively, ad libitum and ...

EAR - ENVIRONMENTAL POLLUTION

The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to ...

Year Published: 2018

Background: People might simultaneously be exposed to noise and carbon monoxide in occupational settings. The previous studies revealed that the inhalation of molecular hydrogen (H2) exerts some healing effects on multiple diseases including hearing loss. Objectives: The levels of free radicals have been shown to increase due to the exposure to noise plus carbon monoxide. This study examined the ...

LIVER - OBSTRUCTIVE JAUNDICE

Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver ...

Year Published: 2019

Gap junctions (GJs) and tight junctions (TJs) are essential to maintain the function of hepatocytes. Changes in biliary tract pressure and the effect of lipopolysaccharide (LPS) may lead to acute obstructive cholangitis (AOC) and cause liver injury via GJ and TJ dysfunction. Hydrogen has been confirmed to have a protective role in various organs during pathological conditions and inflammation. The ...

WHOLE BODY - CANCER

Immunological Effect of Hydrogen Gas-Hydrogen Gas Improves Clinical Outcomes of Cancer Patients

Year Published: 2018

It has been reported that PD-1-expressing CD8+ T cells in the peripheral blood of cancer patients are associated with poor cancer prognosis. In addition, these cells are in a state of energy shortage caused by mitochondrial dysfunction with a low level of PGC-1a. Recently, hydrogen gas was reported to activate PGC-1a, leading to the enhancement of mitochondrial activity. In the present study, we ...

WHOLE BODY - METABOLIC SYNDROME

L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J ...

Year Published: 2019

Obesity and metabolic syndrome (MS) associated with excess calorie intake has become a great public health concern worldwide. L-arabinose, a naturally occurring plant pentose, has a promising future as a novel food ingredient with benefits in MS; yet the mechanisms remain to be further elucidated. Gut microbiota is recently recognized to play key roles in MS. Molecular hydrogen, an emerging ...