In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by Magnesium Passivation/Activation Cycle for Treating Osteoarthritis
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DOI:
10.1002/anie.201806159
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Abstract:
Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H2) is known to have anti‐inflammatory effects; however, the bioavailability of directly administered H2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H2 at inflamed tissues is proposed. The delivery system comprises poly(lactic‐co‐glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra‐muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H2 continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes.| Publish Year | 2018 |
|---|---|
| Country | Taiwan |
| Rank | Positive |
| Journal | Angewandte Chemie International Edition |
| Primary Topic | Bone |
| Secondary Topic | Osteoarthritis |
| Model | Mouse |
| Tertiary Topic | Oxidative Stress |
| Vehicle | Gas (Sustained Release) |
| pH | N/A |
| Application | Implantation |
| Comparison | |
| Complement |