In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by Magnesium Passivation/Activation Cycle for Treating Osteoarthritis

Hsing-Wen Sung, Po-Chien Shih, Qinghua Cui, Wei-Lin Wan, Wei-Tso Chia, Yen Chang, Yu-Jung Lin, Yu-Ru Bow

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DOI: 10.1002/anie.201806159 DOI is the universal ID for this study.

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Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H2) is known to have anti‐inflammatory effects; however, the bioavailability of directly administered H2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H2 at inflamed tissues is proposed. The delivery system comprises poly(lactic‐co‐glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra‐muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H2 continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes.

Publish Year 2018
Country Taiwan
Rank Positive
Journal Angewandte Chemie International Edition
Primary Topic Bone
Secondary TopicOsteoarthritis
Model Mouse
Tertiary TopicOxidative Stress
Vehicle Gas (Sustained Release)
pH N/A
Application Implantation