search - Hydrogen Studies

Hydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes ...

Year Published: 2019

Obstructive sleep apnea (OSA) can cause intermittent changes in blood oxygen saturation, resulting in the generation of many reactive oxygen species (ROS). To discover new antioxidants and clarify the endoplasmic reticulum (ER) stress involved in cardiac injury in OSA, we established a chronic intermittent hypoxia (CIH) rat model with a fraction of inspired O2 (FiO2) ranging from 21% to 9%, 20 ...

SKIN - CANCER

The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats

Year Published: 2019

This study aimed to determine the healing effect of hydrogen-rich water (HRW) on radiotherapy-induced skin injury. Rats were irradiated with a 6 MeV electron beam from a Varian linear accelerator. After skin wound formation, rats were individually administrated with distilled water, HRW (1.0 ppm) or HRW (2.0 ppm). We measured the healing time and observed the healing rate of the wounded surface. ...

BRAIN - ALZHEIMER'S DISEASE

Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer’s ...

Year Published: 2019

Oxidative stress-induced mitochondrial dysfunction plays an important role in the pathogenesis of Alzheimer's disease (AD). Hydrogen molecule, a special antioxidant, can selectively scavenge highly cytotoxic reactive oxygen species such as ·OH, exhibiting a potential to treat AD by reducing oxidative stress. However, there is no effective route to realize the continuous and efficient accumulation ...

LIVER - SURGERY/TRANSPLANTATION

Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on ...

Year Published: 2019

Aim: To compare and evaluate the hepatoprotective effect of liver parenchyma injection of ADSCs and portal vein injection of HRS in laparoscopic hepatic ischemia reperfusion combined with hepatectomy injury in miniature pigs. Methods: Eighteen miniature pigs were randomly assigned to IRI group, HRS group and ADSCs group. HRS was injected through the portal vein 10 min before reperfusion, 1 d, 2 d, ...

LUNG - SEPSIS

Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway

Year Published: 2019

Background: Lung injury is a vital contributor of mortality in septic patients. Our previous studies have found that molecular hydrogen (H2), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2). The aim of this research was to investigate the ...

WHOLE BODY - CANCER

Hydrogen gas improves photothermal therapy of tumor and restrains the relapse of distant dormant ...

Year Published: 2019

Inflammation during photothermal therapy (PTT) of tumor usually results in adverse consequences. Here, a biomembrane camouflaged nanomedicine (mPDAB) containing polydopamine and ammonia borane was designed to enhance PTT efficacy and mitigate inflammation. Polydopamine, a biocompatible photothermal agent, can effectively convert light into heat for PTT. Ammonia borane was linked to the surface of ...

KIDNEY - SEPSIS

Aerosol inhalation of a hydrogen-rich solution restored septic renal function

Year Published: 2019

Sepsis-related acute kidney injury (AKI) is known to be caused by inflammation. We explored the renal protective effects of aerosol inhalation of a hydrogen-rich solution (HRS; hydrogen gas dissolved to saturation in saline) in a mouse model of septic AKI. Septic AKI was induced through 18 hours of cecal ligation and puncture. AKI occurred during the early stage of sepsis, as evidenced by ...

WHOLE BODY - WOUND HEALING

NIR‐Laser‐Controlled Hydrogen‐Releasing PdH Nanohydride for Synergistic ...

Year Published: 2019

For decades, hydrogen (H2) gas has been recognized as an excellent antioxidant molecule that holds promise in treating many diseases like Alzheimer's, stroke, cancer, and so on. For the first time, active hydrogen is demonstrated to be highly efficient in antibacterial, antibiofilm, and wound‐healing applications, in particular when used in combination with the photothermal effect. As a proof of ...

HEART - HEART ATTACK

Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via ...

Year Published: 2019

Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an important role in normal cardiac homeostasis, and obstructions to the autophagy process lead to severe consequences for the heart. Hydrogen exerts an effective therapeutic role in numerous diseases associated with I/R injury via its ...

INTESTINE - INTESTINAL INJURY

MicroRNA Files in the Prevention of Intestinal Ischemia/Reperfusion Injury by Hydrogen Rich Saline

Year Published: 2019

Background Hydrogen rich saline (HRS) has been proven effective against ischemia reperfusion(I/R) injury. However, knowledge on the underlying signaling events remain poor. Having recent highlight of microRNAs(miRNAs) in mediating intestinal I/R injury, we hypothesized that HRS may protect intestine against I/R injury by regulating miRNAs. Method Mice were given intraperitoneal injection of saline ...

LUNG - SARS/COVID

Acidic electrolyzed water potently inactivates SARS-CoV-2 depending on the amount of free available ...

Year Published: 2020

Alcohol-based disinfectant shortage is a serious concern in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Acidic electrolyzed water (EW) with a high concentration of free available chlorine (FAC) shows strong antimicrobial activity against bacteria, fungi, and viruses. Here, we assessed the SARS-CoV-2-inactivating efficacy of acidic EW for use as an alternative ...

SKIN - WOUND HEALING

Skin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing ...

Year Published: 2019

We are the first to report on a new, safe, and effective treatment of infections induced by conditional pathogenic strains with local wet packing with hydrogen water. The new treatment method may also shed light on the therapy of chronic, inflammatory skin ulcers.

LUNG - SEPSIS

Effects of hydrogen on lung injury in wild-type and Nrf2 gene knockout mice: relationship with ...

Year Published: 2019

Objective: To investigate the key role of nuclear factor E2-related factor 2 (Nrf2) in the treatment of lung injury in sepsis mice by regulating Nrf2/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway. Methods: 120 male wild type (WT) and 120 Nrf2 knockout (Nrf2-KO) ICR mice were randomly divided into Sham group, H2 control group (Sham+H2 group), cecal ligation and puncture ...

LIVER - LIVER FUNCTION

Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and ...

Year Published: 2019

Molecular hydrogen (H2) has been shown to have antioxidant and anti-inflammatory activities that may reduce the development and progression of many diseases. In this study, hydrogen-rich water (HRW) was obtained by reacting hybrid magnesium-carbon hydrogen storage materials with water. Then, the effects of intake of HRW on the activities of xenobiotic-metabolizing enzymes, membrane transporters, ...

KIDNEY - POLYCYSTIC KIDNEY DISEASE

Effects of hydrogen-rich water in a rat model of polycystic kidney disease

Year Published: 2019

Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-rich water reduces oxidative stress and has a good effect on kidney injury. We examined whether ...

LIVER - SEPSIS

Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner

Year Published: 2019

Sepsis-induced hepatic dysfunction is considered as an independent risk factor of multiple organ dysfunction syndrome (MODS) and death. Mitophagy, a selective form of autophagy, plays a major role in sepsis-induced organ damage. We have demonstrated that hydrogen gas (H2), a selective antioxidant, exerts protective effects in septic mice. Here, we hypothesize that the therapeutic effects of H2 on ...

BRAIN - BRAIN INJURY

Hydrogen inhalation protects hypoxic–ischemic brain damage by attenuating inflammation and ...

Year Published: 2019

Hypoxic–ischemic brain damage (HIBD) is one of the leading causes of brain injury in infant with high risk of mortality and disability; therefore, it is important to explore more feasible and effective treatment strategies. Here, we assessed the neuroprotective effects of different hydrogen inhalation times for the treatment of HIBD. We induced hypoxia–ischemia in Sprague–Dawley rats ...

KIDNEY - AGING

Protective effects of hydrogen-rich saline against renal ischemia-reperfusion injury by increased ...

Year Published: 2019

Objective: Oxygen free radicals (ROS) are considered to be one of the important factors involved in the pathophysiology of aged renal ischemia-reperfusion (I/R) injury. Hydrogen gas has been reported to alleviate I/R injury by scavenging free radicals. The aim of this study was to evaluate the effect of hydrogen-rich saline (HRS) on renal I/R injury in aged rats. Materials and methods: A rat model ...

BRAIN - ADDICTION

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

Year Published: 2019

Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders. The ever-increasing levels of METH abuse worldwide have necessitated the identification of effective intervention strategies to protect the brain against METH-induced neurotoxicity. The protective effects of molecular hydrogen on ...

BONE - OSTEOPOROSIS

Hydrogen gas protects against ovariectomy-induced osteoporosis by inhibiting NF-κB activation

Year Published: 2019

Objectives: Osteoporosis is a prevalent condition among postmenopausal women, and lacks satisfactory therapeutic options. Hydrogen (H2) has been shown to be effective in alleviating many diseases. This study aimed to investigate the effects of H2 on inhibiting osteoclastogenesis and bone loss in ovariectomized mice. Methods: Osteoclast differentiation from Raw264.7 cells was induced with receptor ...

LUNG - SEPSIS

Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ...

Year Published: 2019

Impact statement: Acute lung injury (ALI), a common complication of many serious health issues, such as serious infection, burns, and shock, is one of the most common critical illnesses in clinical practice with a high mortality rate of 30-40%. There are still short of effective prevention and treatment measures. Evidence is growing that hydrogen-rich saline (HRS) may be an effective drug for the ...

BLOOD - BLOOD COMPOSITION

Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis ...

Year Published: 2019

Aims: Hydrogen (H2) has antioxidant effects. The pharmacologic function of H2 in platelets is not yet clear. Therefore, in this study we sought to investigate the inhibitory effects of H2 on in vitro platelet activation and in vivo prevention of thrombus formation. Main methods: After platelets were incubated with H2-rich saline (HRS), platelet adhesion in whole human blood was assessed in ...

LIVER - SURGERY/TRANSPLANTATION

Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation

Year Published: 2019

Background: Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) in such marginal donors is therefore crucial for reducing the possibility of the primary non-function of grafts ...

LUNG - RHEUMATOID ARTHRITIS

Effect of H 2 treatment in a mouse model of rheumatoid arthritis-associated interstitial lung ...

Year Published: 2019

Rheumatoid arthritis (RA)-associated interstitial lung disease (ILD), a primary cause of mortality in patients with RA, has limited treatment options. A previously established RA model in D1CC transgenic mice aberrantly expressed major histocompatibility complex class II genes in joints, developing collagen II-induced polyarthritis and anti-cyclic citrullinated peptide antibodies and interstitial ...

INTESTINE - IRRITABLE BOWEL SYNDROME

Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, ...

Year Published: 2019

In Japan, alkaline electrolyzed water (AEW) apparatus have been approved as a medical device. And for the patients with gastrointestinal symptoms, drinking AEW has been found to be effective in relieving gastrointestinal symptoms. But some users of AEW apparatus do not have abdominal indefinite complaint. Little attention has been given to the benefit for the users which have no abdominal ...