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Studies Found: 1335

LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress ...

Year Published: 2017

Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver diseases, between steatosis and non‑alcoholic steatohepatitis and liver cirrhosis, which are closely associated with diabetes mellitus. Previous studies have indicated that oxidative stress is a key factor in the development of NAFLD. Molecular hydrogen (H2) may ameliorate oxidative stress injuries by selectively neutralizing ...
NOSE - RHINITIS

Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via ...

Year Published: 2017

Background: It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has been proven effective in selectively reducing ROS in animals models of oxidative damage. We herein ...
INTESTINE - SEPSIS

Hydrogen Gas Protects Against Intestinal Injury in Wild Type but Not NRF2 Knockout Mice with Severe ...

Year Published: 2017

The intestine plays an important role in the pathogenesis of sepsis. Hydrogen gas (H2), which has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, can be effectively used to treat septic mice. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive master switch that regulates the expression of antioxidant and protective enzymes. This study investigated the effects of ...
BRAIN - PARKINSON'S DISEASE

Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease ...

Year Published: 2017

Molecular hydrogen (H2), as a new medical gas, has protective effects in neurological disorders including Parkinson's disease (PD). In our previous report, the neuroprotective effect of drinking water with saturated H2 (H2 water) in PD mice might be due to stomach-brain interaction via release of gastric hormone, ghrelin. In the present study, we assessed the effect of H2-induced ghrelin more ...
SKIN - WOUND HEALING

Wound Healing Effect of Slightly Acidic Electrolyzed Water on Cutaneous Wounds in Hairless Mice via ...

Year Published: 2017

Acidic electrolyzed water is an innovative sanitizer having a wide-spectrum of applications in food industry, and healthcare industry but little is known on its effect and mechanism in wound healing. The study was conducted to identify the effect and mechanism of slightly acidic electrolyzed water (SAEW) on cutaneous wounds in hairless mice. SAEW (pH: 5–6.5, oxidation reduction potential: 800 ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells

Year Published: 2017

Hyperbaric oxygen (HBO) therapy through breathing oxygen at the pressure of above 1 atmosphere absolute (ATA) is useful for varieties of clinical conditions, especially hypoxic-ischemic diseases. Because of generation of reactive oxygen species (ROS), breathing oxygen gas at high pressures can cause oxygen toxicity in the central nervous system, leading to multiple neurological dysfunction, which ...
LUNG - LUNG INJURY

Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats

Year Published: 2017

Background The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats. Methods Rats were treated with OA (0.1 mL/kg) to induce ALI and then administered with HSS (5 mL/kg) by intravenous (iv) and intraperitoneal (ip) injection, respectively. Three hours after the injection with OA, the ...
MOUTH - OBESITY

Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone ...

Year Published: 2017

Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. ...
LIVER - CANCER

Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated ...

Year Published: 2017

The present study was conducted to investigate the protective effect of hydrogen-rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single-blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February ...
LIVER - SLEEP APNEA

Improvement of hydrogen on liver oxidative stress injury in chronic intermittent hypoxia rats

Year Published: 2017

OBJECTIVE:To explore the effects of hydrogen on liver injury in chronic intermittent hypoxia rats and the related oxidative stress mechanism. METHODS:Twenty-four male adult SD rats were randomly divided into 3 groups(n=8):the normoxia group (Norm), the chronic intermittent hypoxia group (CIH), the chronic intermittent hypoxia and hydrogen group (H2 + CIH). Rats in Norm group were exposed in air, ...
EYE - UVEAL INJURY

Effects of hydrogen-rich saline on endotoxin-induced uveitis

Year Published: 2017

The therapeutic effects of hydrogen-rich saline (HRS) have been reported for a wide range of diseases mainly via selectively reducing the amount of reactive oxygen species. Oxidative stress plays an important role in the pathogenesis of uveitis and endotoxin-induced uveitis (EIU). In this study, we investigated whether HRS can mitigate EIU in rats. Sprague-Dawley rats were randomly divided into ...
EYE - RETINAL INJURY

The reason for the amelioration of N-methyl-N-nitrosoureainduced retinitis pigmentosa in rats by ...

Year Published: 2017

Aim: To investigate the effects of hydrogen-rich saline (HRS) on microglia activation and Sirtuin type 1 (Sirt1) in rats with N-methyl-N-nitrosourea (MNU)-induced retinitis pigmentosa (RP). Methods: Rats were divided into norm (N) group, model (M) group and HRS (H) group. Rats in M and H groups were given saline and HRS respectively prior to and after administration of MNU. At one day (d1) and d3 ...
HEART - HIGH BLOOD PRESSURE

Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac ...

Year Published: 2017

Cardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present ...
NOSE - RHINITIS

Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea ...

Year Published: 2017

Objective: To explore the effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells in a guinea pig model of allergic rhinitis (AR) and investigate the underling anti-inflammatory mechanism. Methods: Using random number table, eighteen guinea pigs were divided into three groups (control group/AR group/HRS group, n=6 of each group). AR guinea pig model was built with ovalbumin and ...
NOSE - RHINITIS

Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and ...

Year Published: 2017

It is well known that CD4+CD25+Foxp3+Treg cells play an important role in the development of allergic rhinitis (AR); the defect of cell numbers and functions contribute to AR. Hydrogen has been proven effective in alleviating symptoms of AR. We herein aim to verify the protective effects of hydrogen on CD4+CD25+Foxp3+Treg cells in guinea pigs with AR and to explore the effect of hydrogen-rich ...
MOUTH - GINGIVITIS

Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival ...

Year Published: 2017

The aim of the present study is to investigate protective effects of hydrogen-rich water (HW) against reactive oxygen species (ROS)-induced cellular harmful events and cell death in human gingival fibroblasts (HGF) and three-dimensional (3D-) gingival tissue equivalents. HW was prepared with a magnesium stick in 600-mL double distilled water (DDW) overnight. Dissolved hydrogen was about 1460 ± 50 ...
BRAIN - SURGERY/TRANSPLANTATION

Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats

Year Published: 2017

Postoperative cognitive decline is a major clinical problem with high morbidity and mortality after surgery. Many studies have found that molecular hydrogen (H2) has significant neuroprotection against acute and chronic neurological injury by regulating inflammation and apoptosis. In this study, we hypothesized that H2 treatment could ameliorate the development of cognitive impairment following ...
KIDNEY - ACUTE KIDNEY INJURY

Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β ...

Year Published: 2017

The current research was designed to study the role of hydrogen in renal fibrosis and the renal epithelial to mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1). Hydrogen rich water (HW) was used to treat animal and cell models. Unilateral ureteral obstruction (UUO) was performed on Balb/c mice to create a model of renal fibrosis. Human kidney proximal tubular ...
INTESTINE - INTESTINAL INJURY

Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury due to ...

Year Published: 2017

This study aimed to investigate the protective effects of hydrogen rich water on the intestinal ischemia/reperfusion (I/R) injury in a rat intestinal intussusception (II) model. Ninety Sprague-Dawley rats were randomly assigned into three groups (n = 30 per group). In sham group, rats received laparotomy, and the intestine was exposed for 15 minutes without II. In I/R + saline group and I/R + ...
MUSCLE - SURGERY/TRANSPLANTATION

Protective Effect of Hydrogen Gas Inhalation on Muscular Damage using a Mouse Hind Limb Ischemia ...

Year Published: 2017

Background: Ischemia-reperfusion injury is one of the leading causes of tissue damage and dysfunction, in particular, free tissue transfer, traumatically amputated extremity, and prolonged tourniquet application during extremity surgery. In this study, the authors investigated the therapeutic effects of hydrogen gas on skeletal muscle ischemia-reperfusion injury. Methods: The authors compared the ...
BRAIN - ADDICTION

Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice

Year Published: 2017

Hydrogen therapy is a new medical approach for a wide range of diseases. The effects of hydrogen on central nervous system-related diseases have recently become increasingly appreciated, but little is known about whether hydrogen affects the morphine withdrawal process. This study aims to investigate the potential effects of hydrogen-rich saline (HRS) administration on naloxone-precipitated ...
WHOLE BODY - AGING

Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative ...

Year Published: 2017

Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of proteins, forming disulfide bridges with cysteine or methionine sulfhydryl groups. Decreased Ca2+ signaling is observed in aged cells, probably secondary to the ...
BLOOD - BLOOD COMPOSITION

Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy ...

Year Published: 2017

Molecular hydrogen is an experimental therapeutic agent in biomedicine, however its effects on serum antioxidant markers are poorly described so far. Sixteen healthy men (age 24.6 ± 3.6 years, height 183.3 ± 4.4 cm; weight 83.5 ± 12. 5 kg) participated in this randomized, double blind, placebo-control pilot study. The participants were assigned to receive either 300 mL per day of oral ...
WHOLE BODY - IMMUNE DYSFUNCTION

In Situ Nanoreactor for Photosynthesizing H 2 Gas To Mitigate Oxidative Stress in Tissue ...

Year Published: 2017

Hydrogen (H2) gas can reduce cytotoxic reactive oxygen spe-cies (ROS) that are produced in inflamed tissues. Inspired by natural photosynthesis, this work proposes a multicomponent nanoreactor (NR) that comprises chlorophyll a, L-ascorbic acid, and gold nanoparticles that are encapsulated in a liposomal (Lip) system that can produce H2 gas in situ upon photon absorption to mitigate inflammatory ...
LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

High-content hydrogen water-induced downregulation of miR-136 alleviates non-alcoholic fatty liver ...

Year Published: 2017

This study was aimed to investigate the potential regulatory mechanism of high-content hydrogen water (HHW) in non-alcoholic fatty liver disease (NAFLD). A high-fat diet (HFD)-induced NAFLD mice model and cellular model were prepared. The serum levels of alanine transaminase (ALT), aspartate transaminase (AST), total cholesterol (TCH) and triglycerides (TG) were measured. The expression levels of ...