search - Hydrogen Studies

Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent ...

Year Published: 2016

Diet-induced nonalcoholic fatty liver disease (NAFLD) is characterized by profound lipid accumulation and associated with an inflammatory response, oxidative stress and hepatic mitochondrial dysfunction. We previously demonstrated that some mitochondrial nutrients effectively ameliorated high fat diet (HFD)-induced hepatic steatosis and metabolic disorders. Molecular hydrogen in hydrogen-rich ...

OVARIES - PREMATURE OVARIAN FAILURE

Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of ...

Year Published: 2016

Background: Premature ovarian failure (POF) is a disease that affects female fertility but has few effective treatments. Ovarian reserve function plays an important role in female fertility. Recent studies have reported that hydrogen can protect male fertility. Therefore, we explored the potential protective effect of hydrogen-rich water on ovarian reserve function through a mouse immune POF ...

UTERUS - ENDOMETRIOSIS

Effects of Hydrogen Gas Inhalation on Endometriosis in Rats

Year Published: 2016

Objective: Oxidative stress is generated during the pathophysiology of endometriosis (EMT). Hydrogen (H2) has been demonstrated as a gas antioxidant. The aim of the present study is to evaluate the protective effect of H2 on EMT in rats. Study design: Sprague Dawley rats with surgically induced EMT were randomly received the inhalation of 67% H2-33% oxygen (O2) mixture (1 h/d, 4 weeks) immediately ...

PANCREAS - PANCREATITIS

MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase ...

Year Published: 2016

Molecular hydrogen (H2 ) has been proven to be an effective agent that can cure multiple organ diseases by reducing oxidative stress. Although the protective effect of hydrogen on acute pancreatitis (AP) has been confirmed, its molecular mechanism is still unclear. In this article, we aimed to investigate the changes in pancreatic cell protein expression associated with the protective effect of H2 ...

HEART - AGING

Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells

Year Published: 2016

Background: Substantial evidence indicates that molecular hydrogen (H2) has beneficial vascular effects because of its antioxidant and/or anti-inflammatory effects. Thus, hydrogen-rich water may prove to be an effective anti-aging drink. This study examined the effects of H2on endothelial senescence and clarified the mechanisms involved. Methods and results: Hydrogen-rich medium was produced ...

PREGNANCY - HIGH BLOOD PRESSURE

Hydrogen inhibits cytotrophoblast cells apoptosis in hypertensive disorders complicating pregnancy

Year Published: 2016

Hypertensive disorders complicating pregnancy (HDCP) is one of the most serious medical disorders during pregnancy. Hydrogen is a therapeutic antioxidant and used to treat HDCP effectively. However, the molecular mechanism about the effect of hydrogen on HDCP still remains unclear. In this study, we found ROS content in HDCP group was significantly higher than that in the control and was reduced ...

LUNG - ENVIRONMENTAL POLLUTION

Protective effect of hydrogen on the lung of sanitation workers exposed to haze

Year Published: 2016

Objective: To study the protective effect of hydrogen inhalation on the lungs of sanitation workers exposed to haze. Methods: In this randomized, double-blind, placebo controlled clinical trial, 96 sanitation workers living in Shijiazhuang urban area were recruited during January to February, 2016. All enrolled participants were randomized to 2 groups; the treatment group inhaled H2∶O2 mixture ...

WHOLE BODY - CANCER

Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral ...

Year Published: 2016

Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the ...

WHOLE BODY - CELLULAR REDOX STATE

New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS ...

Year Published: 2016

It is known that increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) can exert harmful effects, altering the cellular redox state. Electrolyzed Reduced Water (ERW) produced near the cathode during water electrolysis exhibits high pH, high concentration of dissolved hydrogen and an extremely negative redox potential. Several findings indicate that ERW had the ...

LIVER - CANCER

Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting ...

Year Published: 2016

Doxorubicin (DOX) remains the most effective anticancer agent which is widely used in several adult and pediatric cancers, but its application is limited for its cardiotoxicity and hepatotoxicity. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for many diseases. In this study, we found that intraperitoneal injection of hydrogen-rich saline (H2 saline) ameliorated ...

OVARIES - OVARIAN INJURY

Protective Effect of Hydrogen Rich Saline Solution on Experimental Ovarian Ischemia Reperfusion ...

Year Published: 2016

Background: The present study aimed to investigate the effects of hydrogen rich saline solution (HRSS) in a rat model of ovarian ischemia-reperfusion injury. Methods: Thirty-six female Wistar-albino rats were grouped randomly, into six groups of six rats. The groups were classified as: sham (S), hydrogen (H), torsion (T), torsion/detorsion (TD), hydrogen-torsion (HT), and ...

LUNG - LUNG INJURY

Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 ...

Year Published: 2016

Seawater instillation-induced acute lung injury involves oxidative stress and apoptosis. Although hydrogen gas inhalation is reportedly protective in multiple types of lung injury, the effect of hydrogen gas inhalation on seawater instillation-induced acute lung injury remains unknown. This study investigated the effect of hydrogen gas on seawater instillation-induced acute lung injury and ...

WHOLE BODY - EXCERCISE

Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes?

Year Published: 2016

Summary Objectives The purpose of this double-blind, randomized, placebo-controlled crossover study was to determine the effects of pre-exercise hydrogen-rich water intake on biomarkers of acid-base homeostasis and post-exercise recovery in female athletes. Methods Eight young female judo athletes (21.4 ± 2.2 years) were randomly assigned to receive either hydrogen-rich water or placebo water ∼ ...

BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with ...

Year Published: 2016

Objective: To investigate the effect of hydrogen-rich water on cerebral edema and aquaporin 1 (AQP1) expression in rats with traumatic brain injury (TBI). Methods: Ninety male Sprague-Dawley (SD) rats were randomly divided into sham operation group, TBI model group, hydrogen-rich water treatment group (H group),with 30 rats in each group. TBI model was reproduced by weight dropping method. The ...

BRAIN - STROKE

Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia–reperfusion injury ...

Year Published: 2016

Hydrogen is a kind of noble gas with the character to selectively neutralize reactive oxygen species. Former researches proved that low-concentration of hydrogen can be used to ameliorating cerebral ischemia/reperfusion injury. Hydrogen electrolyzed from water has a hydrogen concentration of 66.7%, which is much higher than that used in previous studies. And water electrolysis is a potential new ...

BRAIN - BRAIN INJURY

Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress ...

Year Published: 2016

Hydrogen as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. Multiple lines of evidence reveal the protective effects of hydrogen in various models of brain injury. However, the exact mechanism underlying this protective effect of hydrogen against hypoxic-ischemic brain damage (HIBD) is not fully understood. The present study was ...

MOUTH - DENTIN INTEGRITY

Effect of different acidities of electrolyzed water on dentin surface roughness, decalcification and ...

Year Published: 2016

This study investigated the exposed coronal superficial dentin of 28 human molars were immersed in strongly acidic electrolyzed water (AW group), neutral electrolyzed water (NW group), 5% sodium hypochlorite (negative control, NL group), or deionized water (positive control, DW group). Microhardness was determined at 5-min intervals for 60 min. Surface roughness, energy dispersive X-ray ...

EYE - RETINAL INJURY

Protective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor ...

Year Published: 2016

The N-methyl-N-nitrosourea (MNU)-treated rat is typically used as an animal model of chemically-induced retinitis pigmentosa (RP). Reactive oxygen species (ROS) have been recognized as the crucial contributor to the retinal photoreceptor apoptosis seen in MNU-treated rats. In the present study, we explored the therapeutic effects of hydrogen-rich saline (HRS), a selective ROS scavenger, on ...

WHOLE BODY - RADIOPROTECTION

Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous ...

Year Published: 2016

Purpose: The main aim of the present study is to gain mechanistic insights into the modulating effect of molecular hydrogen on the γ-radiation-induced alteration pathways of DNA nucleobases. Materials and methods: Aerated aqueous solutions of calf thymus DNA were exposed to a (60)Co source at doses ranging from 0 to 55 Gy under normoxic conditions, in the presence or not of 0.7 MPa hydrogen or ...

HEART - HEART ATTACK

Hydrogen inhibits isoproterenol‑induced autophagy in cardiomyocytes in vitro and in vivo

Year Published: 2017

A previous study from our group has demonstrated that hydrogen administration can attenuate cardiovascular hypertrophy in vivo by targeting reactive oxygen species‑dependent mitogen‑activated protein kinase signaling. The aim of the present study is to determine the effect of hydrogen on cardiomyocyte autophagy during β‑adrenoceptor activation in vivo and in vitro. We prepared ...

NOSE - RHINITIS

Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in ...

Year Published: 2017

Background: Medical gas hydrogen (H2) has a special role in airway inflammation; however, the effect of H2 on allergic rhinitis (AR) remains unclear. This study explored the possible roles of H2 on the pathogenesis of AR and observed the influences of H2 on cytokines IL-4 and IL-13. Methods: An AR guinea pig model was established by nasal ovalbumin sensitisation. Eighteen guinea pigs were divided ...

BLOOD - HEMOLYTIC ANEMIA

Therapeutic Effect of Hydrogen Injected Subcutaneously on Onion Poisoned Dogs

Year Published: 2017

The purpose of this study was to investigate the therapeutic effect of hydrogen on the therapy of onion poisoned dogs. A total of 16 adult beagle dogs were divided into two groups (control and hydrogen) and all were fed dehydrated onion powder at the dose of 10 g/kg for three days. The dogs of the experimental group were given subcutaneous injection of 0.2 mL/kg of hydrogen for 12 days after ...

BONE MARROW - CANCER

Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by ...

Year Published: 2017

We examined whether consumption of hydrogen-rich water (HW) could ameliorate hematopoietic stem cell (HSC) injury in mice with total body irradiation (TBI). The results indicated that HW alleviated TBI-induced HSC injury with respect to cell number alteration and to the self-renewal and differentiation of HSCs. HW specifically decreased hydroxyl radical (∙OH) levels in the c-kit+ cells of 4 Gy ...

WHOLE BODY - DIABETES (TYPE II)

Subcutaneous injection of H2 is a novel effective treatment for type 2 diabetes

Year Published: 2017

Aims/introduction: In previous studies H2 administration has clearly shown effectiveness in inhibiting diabetes. Here, we evaluated whether subcutaneous injection of H2 shows enhanced efficacy against type 2 diabetes mellitus (T2DM) induced in mice by a high-fat diet and low dose streptozotocin (STZ) treatment. Material and methods: H2 was injected subcutaneously at a dose of 1ml/mouse/week for ...

HEART - SURGERY/TRANSPLANTATION

Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in ...

Year Published: 2017

Generation of free radicals through incomplete reduction of oxygen during ischemia-reperfusion (I/R) is well described. On the other hand, molecular hydrogen (H2) reduces oxidative stress due to its ability to react with strong oxidants and easily penetrate cells by diffusion, without disturbing metabolic redox reactions. This study was designed to explore cardioprotective potential of hypoxic ...