Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice

Bailong Li, Deyun Zhao, Fu Gao, Hainan Zhao, Hu Liu, Jiaming Guo, Jianming Cai, Meizhou Zhu, Pei Zhang, Pengfei Liu, Xiao Lei, Yang Xu, Yanyong Yang, Yuanyuan Chen, Yunhai Chuai

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DOI: 10.1155/2016/1947819 DOI is the universal ID for this study.

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Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the last time of radiation exposure, all the mice were employed for the determination of the body mass (BM) observation, forced swim test (FST), the open field test (OFT), the chromosome aberration (CA), the peripheral blood cells parameters analysis, the sperm abnormality (SA), the lymphocyte transformation test (LTT), and the histopathological studies. And significant differences between the treatment group and the radiation-only groups were observed, showing that H2 could diminish the detriment induced by LDLTR and suggesting the protective efficacy of H2 in multiple systems in mice against LDLTR.

Publish Year 2016
Country China
Rank Positive
Journal Oxidative Medicine and Cellular Longevity
Primary Topic Whole Body
Secondary TopicCancer
Model Mouse
Tertiary TopicRadioprotection
Vehicle Water (Dissolved)
pH Neutral
Application Ingestion