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Studies Found: 1335

BONE MARROW - SURGERY/TRANSPLANTATION

Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease

Year Published: 2016

The incidence of chronic graft-versus-host-disease is rising year by year, which has become the leading cause of non-transplantation related death and has become the most difficult complication of allogeneic hematopoietic stem cell transplantation to deal with. Inflammation and fibrosis play dominant roles in the pathogenesis of chronic graft-versus-host-disease. Studies have shown that molecular ...
LUNG - SURGERY/TRANSPLANTATION

Electrolyzed Saline Irrigation for Elimination of Bacterial Colonization in the Empyema Space

Year Published: 2016

Background: The empyema space is refractory to elimination of bacterial colonization. Electrolyzed saline (ES) was used as intra-pleural irrigation for rapid disinfection of the empyema space. Patients and methods: Twenty consecutive patients with para-pneumonic empyema were reviewed in this study from 2007 to 2015. The empyema space was irrigated by miniaturized thoracoscopic surgery (mini VATS), ...
BRAIN - BRAIN INJURY

Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic ...

Year Published: 2016

Hypoxic-ischemic encephalopathy (HIE) is the major consequence of perinatal asphyxia (PA) in term neonates. Although the newborn piglet is an accepted large animal PA/HIE model, there is no consensus on PA-induction methodology to produce clinically relevant HIE. We aimed to create and to characterize a novel PA model faithfully reproducing all features of asphyxiation including severe hypercapnia ...

Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of ...

Year Published: 2016

Purpose: Bladder ischemia and oxidative stress contribute to the pathogenesis of bladder dysfunction caused by bladder outlet obstruction (BOO). Molecular hydrogen (H2) reportedly acts as an effective antioxidant. We investigated whether oral ingestion of hydrogen water (H2-water) has a beneficial effect on bladder function in a rat model of BOO. Materials and methods: H2-water was made by ...
LUNG - CHRONIC LUNG DISEASE

Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats

Year Published: 2016

Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. We made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at E16.5. The ...

Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative ...

Year Published: 2016

Rheumatoid arthritis (RA) is a chronic inflammatory disease which results in progressive destruction of the joint. In this study, we examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, we evaluated the effect of hydrogen on RA-FLSs development and the expression of ...
WHOLE BODY - AGING

Alkaline Water and Longevity: A Murine Study

Year Published: 2016

The biological effect of alkaline water consumption is object of controversy. The present paper presents a 3-year survival study on a population of 150 mice, and the data were analyzed with accelerated failure time (AFT) model. Starting from the second year of life, nonparametric survival plots suggest that mice watered with alkaline water showed a better survival than control mice. Interestingly, ...
LUNG - SURGERY/TRANSPLANTATION

Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion ...

Year Published: 2016

Aims: Lung ischemia-reperfusion injury (IRI) may be attenuated through carbon monoxide (CO)'s anti-inflammatory effect or hydrogen (H2)'s anti-oxidant effect. In this study, the effects of lung inflation with CO, H2, or both during the cold ischemia phase on graft function were observed. Materials and methods: Rat donor lungs, inflated with 40% oxygen (control group), 500ppm CO (CO group), 3% H2 ...
KIDNEY - HAEMODIALYSIS

Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using ...

Year Published: 2016

Background Oxidative stress (OS) is said to increase in hemodialysis therapy, so that the electrolyzed water-hemodialysis (EW-HD) dissolving hydrogen in hemodialysis fluid has been tried for the reduction of OS. It is reported that the risk of cardiovascular disease events increased if the fraction of reduced albumin (human mercaptalbumin (f(HMA))) was low and that the f(HMA) rose at the dialyzer ...
LUNG - SEPSIS

Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats ...

Year Published: 2016

This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung injury group [lipopolysaccharide (LPS) ...

Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with ...

Year Published: 2016

Previous studies have demonstrated that hydrogen-rich saline (HS) protects against bile duct ligation (BDL)-induced liver injury by suppressing oxidative stress and inflammation. Mitochondria, which are targets of excessive reactive oxygen species and central mediators of apoptosis, have a pivotal role in hepatic injury during obstructive jaundice (OJ); however, the implications of HS in the ...

Molecular hydrogen suppresses activated Wnt/β-catenin signaling

Year Published: 2016

Molecular hydrogen (H2) is effective for many diseases. However, molecular bases of H2 have not been fully elucidated. Cumulative evidence indicates that H2 acts as a gaseous signal modulator. We found that H2 suppresses activated Wnt/β-catenin signaling by promoting phosphorylation and degradation οf β-catenin. Either complete inhibition of GSK3 or mutations at CK1- and GSK3-phosphorylation ...

Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in ...

Year Published: 2016

Purpose: Hydrogen is a proven novel antioxidant that selectively reduces hydroxyl radicals. In this study, we investigated the effects of hydrogen-rich saline solution on the prevention of renal injury induced by ischemia/reperfusion (I/R) and on renal function recovery. Methods: A rat model of renal I/R injury was induced by 45 min occlusion of the left renal pedicle, followed by 108 h ...
BRAIN - STROKE

Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: ...

Year Published: 2016

Recently, it has been suggested that molecular hydrogen (H2) can selectively reduce the levels of hydroxyl radicals (.OH), and ameliorate oxidative and inflammatory injuries to organs in global cerebral ischemia reperfusion models. Global cerebral ischemia/reperfusion (I/R) can induce a sudden activation of inflammatory cytokines and later influence the systemic immunoreactivity which may ...
WHOLE BODY - ENVIRONMENTAL POLLUTION

The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production ...

Year Published: 2016

The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) in macrophages. First, the PQ optimal concentration was determined in RAW264.7 macrophage by treating serum-starved cells with PQ ...
WHOLE BODY - OBESITY

Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance ...

Year Published: 2016

We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibit multiple functions. Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism. H2 was ingested by drinking of H2-water or by ...
MUSCLE - EXCERCISE

Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness

Year Published: 2016

Several studies have reported that molecular hydrogen (H2) acts as a therapeutic medical gas owing to scavenging reactive oxygen species (ROS). However, little is known about effects of H2 on exercise-induced oxidative stress. The purpose of this study was to investigate the effects of weekly hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness (DOMS). Nine ...

Electrolyzed-reduced water mitigates amyloid beta toxicity via DAF-16 in C. elegans

Year Published: 2016

Alzheimer’s disease is an age-related neurodegenerative disease. Extracellular aggregation of amyloid beta is a well-known hallmark of Alzheimer’s disease and believed to be critical for the development of Alzheimer’s disease. Lots of efforts have been put on finding an intervention alleviating amyloid beta toxicity. Electrolyzed-reduced water is generated near cathode by electrolysis of ...

Drinking functional coherent mineral water accompanies a strengthening of the very low frequency ...

Year Published: 2016

Background:Research onfunctional water has revealed itsphysiological functions and health-beneficial effects.Accordingly, thisstudyexploredthe effects of drinking an average dietary volume of functional coherentmineral water (FCMW) on blood pressure, short-term cardiovascular variables,fractal heart rhythm dynamics,and salivary immunoglobulin A.Methods:Fifteenhealthy subjectswere randomized in a ...
WHOLE BODY - GENE EXPRESSION

Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent ...

Year Published: 2016

We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 in therapeutic and preventive medicine. Moreover, H2 regulates various signal transduction pathways and the expression of many genes. However, the primary targets of H2 in the signal transduction pathways are unknown. ...
WHOLE BODY - ROS-SCAVENGING

The Antioxidative Effect of Hydrogen Water Drinking in Blood

Year Published: 2016

To confirm the antioxidative effect of hydrogen water drinking, the participants were divided into two groups, purified water (PW) drinking group (n=20) and hydrogen water (HW) drinking group (n=20) because of cross test in each 10 in a group. Purified water (pH 6.9, +432mV) was produced only by physical filtering using commercial carbon filter, and hydrogen water (Few Hydrogen Rich WaterTM, ...
WHOLE BODY - SURGERY/TRANSPLANTATION

Fast escape of hydrogen from gas cavities around corroding magnesium implants

Year Published: 2013

Magnesium materials are of increasing interest in the development of biodegradable implants as they exhibit properties that make them promising candidates. However, the formation of gas cavities after implantation of magnesium alloys has been widely reported in the literature. The composition of the gas and the concentration of its components in these cavities are not known as only a few studies ...
EYE - SURGERY/TRANSPLANTATION

Hydrogen prevents corneal endothelial damage in phacoemulsification cataract surgery

Year Published: 2016

In phacoemulsification, ultrasound induces hydroxyl radical (·OH) formation, damaging corneal endothelium. Whether H2 can prevent such oxidative damage in phacoemulsification was examined by in vitro and in vivo studies. H2 was dissolved in a commercial irrigating solution. The effects of H2 against ·OH generation were first confirmed in vitro by electron-spin resonance (ESR) and hydroxyphenyl ...
PREGNANCY - NEUROPROTECTION

Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of ...

Year Published: 2016

Exposure to inflammation in utero is related to perinatal brain injury, which is itself associated with high rates of long-term morbidity and mortality in children. Novel therapeutic interventions during the perinatal period are required to prevent inflammation, but its pathogenesis is incompletely understood. Activated microglia are known to play a central role in brain injury by producing a ...
WHOLE BODY - SEPSIS

Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a ...

Year Published: 2016

Multiple organ dysfunction syndrome (MODS) is a leading cause of mortality in critically ill patients. Hyperoxia treatment may be beneficial to critically ill patients. However, the clinical use of hyperoxia is hindered as it may exacerbate organ injury by increasing reactive oxygen species (ROS). Hydrogen gas (H2) exerts a therapeutic antioxidative effect by selectively reducing ROS. Combination ...