Hydrogen inhibits cytotrophoblast cells apoptosis in hypertensive disorders complicating pregnancy

H. Li, Li-Li Guo, Xiang Yang, Z. Guan

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DOI: 10.14715/cmb/2016.62.6.11 DOI is the universal ID for this study.

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Hypertensive disorders complicating pregnancy (HDCP) is one of the most serious medical disorders during pregnancy. Hydrogen is a therapeutic antioxidant and used to treat HDCP effectively. However, the molecular mechanism about the effect of hydrogen on HDCP still remains unclear. In this study, we found ROS content in HDCP group was significantly higher than that in the control and was reduced markedly in the presence of 100μmol/L hydrogen. IL6, Caspase3, Bax1, P-JAK2, P-Stat3 and P-p38 expression was much higher than the control, and was notably decreasedby the application of 100μmol/L hydrogen. Bcl2 expression in HDCP group was notably lower than the control and was increased by 100 μmol/L hydrogen. The apoptosis rate of cytotrophoblast cells was decreased, andratio of cytotrophoblast cells at G1 and G2 phase was increased and decreased by hydrogen, respectively. All those data indicated a potential molecular mechanism of hydrogen-mediated treatment in HDCP.

Publish Year 2016
Country China
Rank Positive
Journal Cellular and Molecular Biology
Primary Topic Pregnancy
Secondary TopicHigh Blood Pressure
Model Cell Culture
Tertiary TopicOxidative Stress
Vehicle Medium (Dissolved)
pH Neutral
Application Culture Media