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Studies Found: 1335

MOUTH - PERIODONTITIS

Biological toxicity of acid electrolyzed functional water: Effect of oral administration on mouse ...

Year Published: 2011

Objective: Acid electrolyzed functional water has been used in a variety of ways because of its antiseptic action. In the present study, we investigated both the systemic and gastrointestinal effects of ingesting acid electrolyzed functional water, from the perspective of its use in mouthwash. Materials and methods: Seventeen mice (three weeks old) were used in the experiment. Three of the mice ...
SKIN - WOUND HEALING

Effects of Electrolyzed Acidic Water on Infected Wounds in Mice

Year Published: 2011

Acidic water with a lower pH has strong anti-bacterial effects. We investigated the effects of irrigation with electrolyzed acidic water (EAW) on infected wounds in mice. Five-week-old female C57 BL/6J mice were used; a patch of their back skin was removed and covered by a plastic sheet, that had been inoculated with Staphylococcus aureus. We divided the mice into three groups: a non-irrigation ...
BRAIN - STROKE

Hydrogen Inhalation is Neuroprotective and Improves Functional Outcomes in Mice After Intracerebral ...

Year Published: 2011

Oxidative stress contributes significantly to the development of secondary brain injury after intracerebral hemorrhage (ICH). It has been previously demonstrated that hydrogen gas can decrease oxidative stress by scavenging reactive oxygen species. We hypothesized that hydrogen therapy will reduce brain oxidative stress in mice after ICH and thereby will lead to reduced brain edema and improved ...
KIDNEY - ACUTE KIDNEY INJURY

Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using ...

Year Published: 2011

Purpose: We assessed intrarenal oxygenation in gentamicin-induced nephrotoxicity (GIN) and the protective effect of hydrogen-rich water (HW) against GIN using blood oxygenation level-dependent magnetic resonance (MR) imaging. Materials and methods: We acquired T(2)*-weighted images (T(2)*WI) of 21 rats on Days 0, 2, 4, and 7 using a 1.5-tesla MR imaging system. The rats were divided into 3 groups ...
BRAIN - STROKE

Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ...

Year Published: 2011

Hydrogen gas is neuroprotective in cerebral ischemia animal models. In this study, we tested the neuroprotective effects of hydrogen saline, which is safe and easy to use clinically, in a rat model of middle cerebral artery occlusion (MCAO). Sprague-Dawley male rats weighting 250-280 g were divided into sham, MCAO plus hydrogen saline and MCAO groups, and subjected to 90-min ischemia followed by ...
EAR - HEARING LOSS

Saturated hydrogen saline protects against noise–induced hearing loss

Year Published: 2011

Objective: To study effects of saturated hydrogen saline in preventing noise–induced hearing loss. Methods: Fifteen guinea pigs were randomly divided into 3 groups (5 each), group one was for control, group two was treated with normal saline and group three was treated with saturated hydrogen saline, which was given intraperitoneally at 1 hour before noise exposure at 1 ml/100 g. One hundred ...
LUNG - ENVIRONMENTAL POLLUTION

Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats

Year Published: 2011

Exposure to paraquat leads to acute lung injury and oxidative stress is widely accepted as a contributor to paraquat-induced acute lung injury. Recent studies have reported that consumption of water with dissolved molecular hydrogen to a saturated level (hydrogen water) prevents oxidative stress-induced diseases. Here, we investigated whether consumption of saturated hydrogen saline protects rats ...
PREGNANCY - NEUROPROTECTION

Protective Effects of Hydrogen on Fetal Brain Injury During Maternal Hypoxia

Year Published: 2011

This study aimed to investigate the effects of hydrogen on fetal brain injury during maternal hypoxia. Pregnant rats (n=12, at gestational day 17) were randomly assigned into three groups; air, hypoxia, and hypoxia plus hydrogen groups were put into a chamber and flushed with room air (21% O2 and 79% N2), hypoxia (8% O2 and 92% N2), and hypoxia with hydrogen mixture (2% H2, 8% O2 and 90% N2), ...
PANCREAS - DIABETES (TYPE I)

Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes ...

Year Published: 2011

Insulin-producing cells express limited activities of anti-oxidative enzymes. Therefore, reactive oxygen species (ROS) produced in these cells play a crucial role in cytotoxic effects. Furthermore, diabetes mellitus (DM) development is closely linked to higher ROS levels in insulin-producing cells. Hita Tenryosui Water(®) (Hita T. W., Hita, Japan) and Nordenau water (Nord. W., Nordenau, Germany), ...
EAR - HEARING LOSS

Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs

Year Published: 2011

It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen. Guinea pigs received normal water or hydrogen-rich water for 14 days ...
BRAIN - BRAIN INJURY

Protective Effect of Hydrogen Gas Therapy After Germinal Matrix Hemorrhage in Neonatal Rats

Year Published: 2011

Germinal matrix hemorrhage (GMH) is a neurological disease of very low birth weight premature infants leading to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Hydrogen (H2) is a potent antioxidant shown to selectively reverse cytotoxic oxygen-radical injury in the brain. This study investigated the therapeutic effect of hydrogen gas after neonatal GMH injury. Neonatal ...
PANCREAS - DIABETES (TYPE I)

Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes ...

Year Published: 2011

Electrolyzed reduced water, which is capable of scavenging reactive oxygen species, is attracting recent attention because it has shown improved efficacy against several types of diseases including diabetes mellitus. Alloxan produces reactive oxygen species and causes type 1 diabetes mellitus in experimental animals by irreversible oxidative damage to insulin-producing β-cells. Here, we showed ...
MOUTH - DENTURE CARE

Cleansing effect of the alkaline ionized water on microorganisms of the denture surface

Year Published: 2011

Purpose: The purpose of this study was to evaluate the cleansing effect of recently developed alkaline ionized water, e-WASH, on microorganisms of the denture surface. Materials and methods: Removable partial and complete dentures were randomly assigned to the experimental group of 41 dentures, and the control group of 26. The denture was immersed in the e-WASH solution (experimental group), or ...
EYE - CORNEAL INJURY

Hydrogen and N-Acetyl-L-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse Corneal ...

Year Published: 2011

To investigate the role of reactive oxygen species (ROS) as the prime initiators of the angiogenic response after alkali injury of the cornea and observe the effects of antioxidants in preventing angiogenesis. The corneal epithelia of SOD-1-deficient mice or wild-type (WT) mice were removed after application of 0.15 N NaOH to establish the animal model of alkali burn. ROS production was ...
LIVER - CANCER

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy ...

Year Published: 2011

Background: Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces ...
MOUTH - PERIODONTITIS

Hydrogen-rich water attenuates experimental periodontitis in a rat model

Year Published: 2011

Reactive oxygen species (ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat model of periodontitis. A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water. The rats ...
LUNG - SURGERY/TRANSPLANTATION

The effect of donor treatment with hydrogen on lung allograft function in rats

Year Published: 2011

Because inhaled hydrogen provides potent anti-inflammatory and antiapoptotic effects against acute lung injury, we hypothesized that treatment of organ donors with inhaled hydrogen during mechanical ventilation would decrease graft injury after lung transplantation. Orthotopic left lung transplants were performed using a fully allogeneic Lewis to Brown Norway rat model. The donors were exposed to ...
BRAIN - BRAIN INJURY

The effect of hydrogen-rich saline on the brain of rats with transient ischemia

Year Published: 2011

Background: Due to its antioxidant and anti-inflammatory properties, hydrogen gas (H(2)) has protective effects on a variety of organs from damage induced by ischemia/reperfusion (I/R). In this study, we tested the protective effect of hydrogen-rich saline on the brain in a global cerebral I/R model. Materials and methods: We used a four-vessel occlusion model of global cerebral ischemia (15 min) ...
WHOLE BODY - DIABETES (TYPE II)

Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy ...

Year Published: 2011

Recent extensive studies have revealed that molecular hydrogen (H(2)) has great potential for improving oxidative stress-related diseases by inhaling H(2) gas, injecting saline with dissolved H(2), or drinking water with dissolved H(2) (H(2)-water); however, little is known about the dynamic movement of H(2) in a body. First, we show that hepatic glycogen accumulates H(2) after oral administration ...
MUSCLE - MUSCULAR DYSTROPHY

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of ...

Year Published: 2011

Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging ...
BONE - RHEUMATOID ARTHRITIS

Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through ...

Year Published: 2011

Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated that hydrogen inhibits type I allergy through modulating intracellular signal transduction. In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon γ LPS/IFNγ-induced nitric ...
INTESTINE - IRRITABLE BOWEL SYNDROME

The effects of methane and hydrogen gases produced by enteric bacteria on ileal motility and colonic ...

Year Published: 2011

Background: Gases produced by intestinal flora may modulate intestinal motor function in healthy individuals as well as those with functional bowel disease. Methane, produced by enteric bacteria in the human gut, is associated with slowed intestinal transit and constipation. The effects of hydrogen, another main gas produced by bacterial fermentation in the gut, on small bowel and colonic motor ...
BRAIN - STROKE

Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein ...

Year Published: 2011

Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched air inhalation is a neuroprotective approach with proven antioxidant potential, ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism ...

Year Published: 2011

We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NFκB) signaling pathway. VILI was generated in male C57BL6 mice by performing a ...
EYE - RETINAL INJURY

Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress ...

Year Published: 2011

Retinal neovascularization or retinopathy is a proliferative disorder of the retinal capillaries and is the primary cause of blindness. Some studies have shown that oxidative stress plays an important role in hyperoxia-induced retinal neovascularization. Previous reports have indicated that hydrogen has a therapeutic, antioxidant activity by selectively reducing hydroxyl radicals. This study ...