Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging

Akihiro Kitamura, Kenya Murase, Sakie Okada, Taro Matsushita, Yoshinori Kasukabe

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DOI: 10.2463/mrms.10.169 DOI is the universal ID for this study.

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Purpose: We assessed intrarenal oxygenation in gentamicin-induced nephrotoxicity (GIN) and the protective effect of hydrogen-rich water (HW) against GIN using blood oxygenation level-dependent magnetic resonance (MR) imaging.

Materials and methods: We acquired T(2)*-weighted images (T(2)*WI) of 21 rats on Days 0, 2, 4, and 7 using a 1.5-tesla MR imaging system. The rats were divided into 3 groups of seven each: control rats had free access to standard water and no gentamicin (GM) injection; rats designated the GM group had free access to standard water and were injected with GM (80 mg/kg/day) subcutaneously for 7 days; and the third group, designated the GM+HW group, had free access to HW and were injected with GM. R(2)* (=1/T(2)*) was estimated from T(2)*WI.

Results: R(2)* values in the cortex were significantly decreased on Days 2, 4, and 7 compared with those on Day 0 in the GM group but not significantly changed in the control and GM+HW groups. R(2)* values in the medulla did not change significantly in any group. Conclusions: Our findings suggested reduced oxygen utility, mainly in the cortex, in gentamicin-induced nephrotoxicity and an ameliorative effect of hydrogen-rich water against GIN.

Publish Year 2011
Country Japan
Rank Positive
Journal Magnetic Resonance in Medical Sciences
Primary Topic Kidney
Secondary TopicAcute Kidney Injury
Model Rat
Tertiary TopicAntibiotic Toxicity (Gentamicin)
Vehicle Water (Dissolved)
pH Neutral
Application Ingestion