search - Hydrogen Studies

Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic ...

Year Published: 2010

Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5-2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic ...

KIDNEY - HAEMODIALYSIS

A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water ...

Year Published: 2010

Background: Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects. Methods: Dialysis solution with H(2) (average ...

EYE - RETINAL INJURY

Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops ...

Year Published: 2010

Purpose: Retinal ischemia-reperfusion (I/R) injury by transient elevation of intraocular pressure (IOP) is known to induce neuronal damage through the generation of reactive oxygen species. Study results have indicated that molecular hydrogen (H(2)) is an efficient antioxidant gas that selectively reduces the hydroxyl radical (*OH) and suppresses oxidative stress-induced injury in several organs. ...

WHOLE BODY - CANCER

Growth Suppression of HL60 and L6 Cells by Atomic Hydrogen

Year Published: 2010

We previously reported electrolyzed reduced water (ERW) which produced near the cathode by electrolysis has a reductive activity. We also revealed that ERW contains both molecular hydrogen and platinum nanoparticles (Pt nps) derived from platinum-coated titanium electrodes. Pt nps have catalysis activity converting molecular hydrogen to atomic hydrogen. Thus, we regard a solution containing both ...

HEART - SURGERY/TRANSPLANTATION

Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon ...

Year Published: 2010

Recent advances in novel medical gases, including hydrogen and carbon monoxide (CO), have demonstrated significant opportunities for therapeutic use. This study was designed to evaluate the effects of inhaled hydrogen or CO, or both, on cold ischemia/reperfusion (I/R) injury of the myocardium. Syngeneic heterotopic heart transplantation was performed in rats after 6 or 18 hours of cold ischemia in ...

BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced ...

Year Published: 2010

This study is to examine if hydrogen-rich saline reduced amyloid beta (Abeta) induced neural inflammation, and learning and memory deficits in a rat model. S-D male rats (n=84, 280-330g) were divided into three groups, sham-operated, Abeta1-42 injected and Abeta1-42 plus hydrogen-rich saline-treated animals. Hydrogen-rich saline (5ml/kg, i.p., daily) was injected for 14days after ...

LIVER - OBSTRUCTIVE JAUNDICE

Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice

Year Published: 2010

Hydrogen selectively reduces levels of hydroxyl radicals and alleviates acute oxidative stress in many models. Hydrogen-rich saline provides a high concentration of hydrogen that can be easily and safely applied. In this study, we investigated the effects of hydrogen-rich saline on the prevention of liver injury induced by obstructive jaundice in rats. Male Sprague-Dawley rats (n=56) were divided ...

BRAIN - STROKE

Protective effect of saturated hydrogen saline against cerebral ischemia-reperfusion injury in rats

Year Published: 2010

Objective To study the protective effect of saturated hydrogen saline against cerebral ischemia-reperfusion injury and the related mechanism. Methods Rat middle cerebral artery occlusion (MCAO) models were established by thread ligation of the middle cerebral artery. The rats were sacrificed 24 h later. The cerebral infarction volume was determined by TTC staining, the water content in brain ...

BONE MARROW - SURGERY/TRANSPLANTATION

Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in ...

Year Published: 2010

Cell therapy with bone marrow multipotential stromal cells/mesenchymal stem cells (MSCs) represents a promising approach in the field of regenerative medicine. Low frequency of MSCs in adult bone marrow necessitates ex vivo expansion of MSCs after harvest; however, such a manipulation causes cellular senescence with loss of differentiation, proliferative, and therapeutic potentials of MSCs. ...

KIDNEY - CANCER

Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced ...

Year Published: 2010

Our aim was to assess the protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT (DCE-CT). DCE-CT studies were performed in 30 rats (8 weeks old) on days 0, 2, 4 and 7 using multidetector row CT. The rats were divided into three groups: a control group (n = 6) with free access to standard water and without cisplatin injection, a ...

NOSE - RHINOSINUSITIS

Antibacterial effect of electrolysed acid water on the nasal discharge from patients with chronic ...

Year Published: 2010

This study was conducted to determine whether electrolysed acid water (EAW) increased the antibacterial effect of irrigating solution used in the management of chronic rhinosinusitis (CRS). One hundred CRS patients were recruited from April 2008 to February 2009. Four swab specimens were taken from the ipsilateral middle meatus of each patient and one was placed in a Thanswab tube, while the other ...

LUNG - SURGERY/TRANSPLANTATION

Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury ...

Year Published: 2010

Successful abrogation of ischemia/reperfusion (I/R) injury of lung grafts could significantly improve short- and long-term outcomes for lung transplant (LTx) recipients. Hydrogen gas has potent antioxidant and antiapoptotic properties and has been recently used in number of experimental and clinical studies. The purpose of this research was to investigate whether inhaled hydrogen gas could reduce ...

LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation ameliorates ventilator-induced lung injury

Year Published: 2010

Mechanical ventilation (MV) can provoke oxidative stress and an inflammatory response, and subsequently cause ventilator-induced lung injury (VILI), a major cause of mortality and morbidity of patients in the intensive care unit. Inhaled hydrogen can act as an antioxidant and may be useful as a novel therapeutic gas. We hypothesized that, owing to its antioxidant and anti-inflammatory properties, ...

KIDNEY - HAEMODIALYSIS

Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with ...

Year Published: 2010

Background: T-cell damage by increased oxidative stress in end-stage renal disease (ESRD) patients undergoing chronic haemodialysis (HD) led to the increased T-cell apoptosis and the alteration of surface markers and Th1/Th2 ratio in CD4(+) T lymphocytes. Antioxidant electrolysed-reduced water (ERW) was used as the dialysate in ESRD patients undergoing chronic HD to test for improved oxidative ...

BRAIN - TRAUMATIC BRAIN INJURY

Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative ...

Year Published: 2010

Traumatic brain injury (TBI) is a leading cause of mortality and disability among the young population. It has been shown that hydrogen gas (H(2)) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (OH, the most cytotoxic ROS). Recently, we have found that H(2) inhalation significantly improved the survival rate and organ damage of septic mice. In the present study, ...

BRAIN - BRAIN INJURY

Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs

Year Published: 2010

Hydrogen (H2) has been reported to neutralize toxic reactive oxygen species. Oxidative stress is an important mechanism of neuronal damage after perinatal asphyxia. We examined whether 2.1% H2-supplemented room air (H2-RA) ventilation would preserve cerebrovascular reactivity (CR) and brain morphology after asphyxia/reventilation (A/R) in newborn pigs. Anesthetized, ventilated piglets were ...

BRAIN - AGING

Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

Year Published: 2010

Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations ...

SPINE - SPINAL CORD INJURY

Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats

Year Published: 2010

In the present study, we examined the mechanisms of hydrogen-rich saline, a reported therapeutic antioxidant, in the treatment of acute spinal cord contusion injury. Male Sprague-Dawley rats were used to produce a standardized model of contuses spinal cord injury (125 kdyn force). Hydrogen-rich saline was injected intraperitoneally (5 ml/kg) immediately, and at 24 and 48 h after injury. All rats ...

PANCREAS - PANCREATITIS

Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats

Year Published: 2010

Molecular hydrogen, which reacts with the hydroxyl radical, has been considered as a novel antioxidant. Here, we evaluated the protective effects of hydrogen-rich saline on the l-arginine (l-Arg)-induced acute pancreatitis (AP). AP was induced in Sprague-Dawley rats by giving two intraperitoneal injections of l-Arg, each at concentrations of 250mg/100g body weight, with an interval of 1h. ...

WHOLE BODY - BACTERIAL INFECTION

Effect of Alkaline Ionized Water on Stabilization of Antioxidation, Antithrombosis and Antibacterial ...

Year Published: 2010

In this study, the stable maintenance of bioactivity in alkaline ionized water (AIW) and antibacterial effects of AIW were evaluated to confirm benefits of AIW. As controls, purified water (PW) and tap drinking water (DW) were used. The pH and ORP (oxidation-reduction potential) of AIW, PW and DW used were 9.5 and 120 mV, 7.2 and 144 mV, and 7.3 and 564 mV, respectively. High level of minerals was ...

WHOLE BODY - CANCER

Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum ...

Year Published: 2010

In order to erase reactive oxygen species (ROS) related with the proliferation of tumor cells by reducing activity of hydrogen, we developed functional water containing nano-bubbles (diameters: <900 nm for 71%/population) hydrogen of 1.1-1.5 ppm (the theoretical maximum: 1.6 ppm) with a reducing ability (an oxidation-reduction potential -650 mV, normal water: +100-200 mV) using a ...

KIDNEY - SURGERY/TRANSPLANTATION

Oral hydrogen water prevents chronic allograft nephropathy in rats

Year Published: 2010

Reactive oxygen species (ROS) contribute to the development of interstitial fibrosis and tubular atrophy seen in chronic allograft nephropathy (CAN). As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of kidney transplantation, in which allografts from Lewis rats were orthotopically transplanted into Brown Norway ...

HEART - HEART ATTACK

Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and ...

Year Published: 2011

To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R). Sixty-six rats were equally randomized to three groups: sham-operated group, I/R group (control group) and I/R plus H(2) saline treatment group. Myocardial I/R was established by occlusion of the left anterior descending (LAD) coronary artery ...

THYMUS - RADIOPROTECTION

Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice

Year Published: 2011

Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage, especially as a therapeutic gas. Here in this study, we found that H(2) protects ...

WHOLE BODY - DYSLIPIDEMIA

Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level

Year Published: 2010

Electrolyzed reduced water (ERW) containing hydrogen molecules and Pt nanoparticles is expected as a new antioxidant. Thiobarbituric acid reactive substances (TBARS) assay revealed that ERW had an inhibitory effect on the oxidation of low-density lipoproteins (LDL). In addition, ERW significantly suppressed LDL oxidation in the medium cultured J.774.A1 macrophage like cells. ERW inhibited Cu2+ ...