Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: a pilot study

Matilda Vojnovic, Patrik Drid, Sergej M. Ostojic, Tatjana Trivic

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Molecular hydrogen is an experimental therapeutic agent in biomedicine, however its effects on serum antioxidant markers are poorly described so far. Sixteen healthy men (age 24.6 ± 3.6 years, height 183.3 ± 4.4 cm; weight 83.5 ± 12. 5 kg) participated in this randomized, double blind, placebo-control pilot study. The participants were assigned to receive either 300 mL per day of oral hydrogen-rich water or placebo (tap water) for 4 weeks, and were evaluated at baseline, and following 4-weeks of intervention. Hydrogen-rich water intervention significantly improved serum activities of superoxide dismutase and glutathione as compared to the placebo (P < 0.05), while no differences were observed between groups for changes in catalase and glutathione peroxidase at 4-week follow-up. In addition, hydrogen-rich water notably reduced serum malondialdehyde levels at post-administration, with change being significantly different comparing to placebo (- 25.8% vs. 11.7%; P < 0.001). In conclusion, hydrogen-rich water might be recognized as a novel agent to prevent oxidative stress or minimize its damaging effects by enhancing antioxidant enzymes capacity in healthy men. However, a mechanism of its antioxidant action remains unknown.

Publish Year 2017
Country Serbia
Rank Positive
Journal Current Topics in Neutraceutical Research
Primary Topic Blood
Secondary TopicBlood Composition
Model Human
Tertiary TopicRedox Potential
Vehicle Water (Mg-Chemico)
pH Alkaline
Application Ingestion