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Hydrogen Nanobubbles Inhibit Oxidative Stress and Myocardial Fibrosis to Reverse Chemotherapy-Induced Myocardial Injury
The most severe side effect of chemotherapy is cardiotoxicity, frequently causing myocardial injury characterized by excessive oxidative stress and fibrosis for which effective treatments are lacking. To address this, a hydrogen delivery system, hydrogen nanobubbles (HNBs), was constructed…
Phase-Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar-Reduced Regeneration of Burn Wounds
Burn wounds complicated by bacterial infection and fibrotic scarring remain a major clinical challenge, demanding therapeutics capable of coordinated infection control, inflammation modulation, and tissue regeneration. Here, we report a phase-programmed microneedle (MN) patch (QR/AB-MNs) that…
A randomized controlled double-blind study on the brain protection of infantile patients with epileptic spasm syndrome through atomized inhalation of hydrogen-oxygen gas
Objective Hydrogen-oxygen nebulization inhalation has a brain-protective effect. This study aims to evaluate its short-term efficacy and safety as an adjuvant treatment for infantile epileptic spasms syndrome (IESS). Methods A prospective randomized double-blind controlled trial enrolled 53 IESS…
IBS and SIBO: Gut Microbiota, Pathophysiology, and Non-Pharmacological Interventions
Irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) share symptoms such as abdominal pain, bloating, and altered bowel habits. Both are linked to dysbiosis and gut-brain axis dysfunction. IBS is a multifactorial disorder characterized by abnormal motility, visceral…
Comparative Efficacy of Coral Calcium Carried Hydrogen versus Dexamethasone in a Mouse Model of Allergic Contact Dermatitis
Introduction Allergic contact dermatitis (ACD) is a common T cell-mediated delayed hypersensitivity reaction characterized by chronic skin inflammation. Coral calcium carried hydrogen (CCH), a novel solid-phase hydrogen carrier, enables sustained hydrogen release and demonstrates superior stability…
Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes
Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes
Association of Self-Selected Hydrogen-Rich Water Consumption with 6-Month Changes in Chair-Stand Performance and Gait Speed among Community-Dwelling Older Adults Attending Community Salons
To examine whether self-selected hydrogen-rich water consumption was associated with 6-month changes in physical function among community-dwelling older adults attending community salons. This prospective observational study included 128 older adults in Hiroshima, Japan. Participants were…
Hydrogen-Rich Water Effects in Metabolic Syndrome Stratified by Breath Hydrogen
Objectives: Metabolic syndrome increases the risk of cardiovascular disease and type 2 diabetes. Hydrogen-rich water (HRW) may improve metabolic function, though responses may vary with endogenous hydrogen production. This randomized, double-blind, placebo-controlled trial examined the effects…
Molecular hydrogen in biomedicine: A comprehensive review of mechanisms, multi-system therapeutic effects, and emerging delivery strategies
Molecular hydrogen (H2) has attracted increasing interest as a potential therapeutic agent because of its redox-modulating and anti-inflammatory properties. This review summarizes current evidence regarding its biological mechanisms, multisystem effects, and emerging delivery strategies…
Transcriptome‐Based Evaluation of Hydrogen Gas Effects for Preventing <scp>UVA</scp> ‐Induced Photoaging Using an Artificial Skin Model
ABSTRACT Aim Intermittent hydrogen gas inhalation has the potential to prevent UVA‐induced photoaging by reducing oxidative stress, although the underlying molecular mechanisms remain unclear. Additionally, alternatives to animal experiments are recommended for studies not primarily focused…
Self-Adaptive Hydrogen Nano-Delivery System in Glaucoma Management: Synergistic Antioxidation and Anti-inflammation Therapeutic Strategy
Glaucoma-induced optic nerve damage is known to be a leading cause of blindness worldwide, yet current therapies mainly focus on reducing intraocular pressure without paying significant attention to the oxidative stress and inflammation in ocular tissues. Here, we address this issue by developing…
Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity
ABSTRACT Immunogenic cell death (ICD) induced by calcium overload holds great promise for reversing the immunosuppressive tumor microenvironment (TME) and improving cancer immunotherapy. However, achieving sustained calcium dysregulation remains a major challenge. Herein, we report a novel…
Hydrogen-rich saline treatment modulates proteomic profiles to mitigate cataract development in a N-methyl-N-nitrosourea-induced rat model
Purpose: Cataracts are associated with oxidative stress-induced damage to lens proteins. This study aims to identify differentially expressed proteins (DEPs) associated with the protective effects of hydrogen-rich saline (HRS) against N-methyl-N-nitrosourea (MNU)-induced cataracts, utilizing…
Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial
Background: Clinical or experimental trials have shown that hydrogen-rich water has anti-inflammatory properties, but its use for keloids has not been studied. This research explores HRW's therapeutic potential and mechanism for keloid treatment. Methods: 21 keloid patients scheduled for two-stage…
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice
Molecular hydrogen (H2) exhibits anti-inflammatory and antioxidant properties. However, its role in ultraviolet B (UVB)-induced skin carcinogenesis remains unclear. Male HR-1 hairless mice received continuous H2 (2% hydrogen gas inhalation plus hydrogen-rich water (HRW)) or control treatment…
Molecular hydrogen in cancer therapy: Bioactive materials for tumor-targeted delivery and in situ generation
Molecular hydrogen (H2) therapy has emerged as a promising adjunctive strategy in oncology, primarily attributed to its selective antioxidant, anti-inflammatory, and cytoprotective properties. Advances have been driven by the integration of mechanistic studies on H2-mediated redox regulation…
Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock-A Proof-of-Concept Study
Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for hemorrhagic shock in the torso has become increasingly common as a bridge to definitive hemostasis. Hydrogen molecules, distributed throughout the bloodstream, alleviate ischemic injury but cannot reach…
Selective Antimicrobial Activity of Slightly Acidic Electrolyzed Water: Differential Effects on Harmful and Beneficial Bacteria in Microbial Fermentation Systems
Microbial contamination in fermentation systems poses significant risks to safety and efficiency, as harmful microbes can proliferate while conventional disinfectants often indiscriminately harm beneficial lactic acid bacteria (LAB). This study investigated the selective antimicrobial activity…
Antibacterial and antibiofilm effects of immobilized hydrogen on pathogenic oral bacteria
Aims: Hydrogen, a colorless and odorless gas, possesses various physiological activities, including anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-apoptotic effects. Clinical applications of hydrogen have been investigated in the medical field. However, few studies have…
Comparison of hydrogen administration methods in the treatment of radiation-induced heart disease in rats
Ionizing radiation is a known risk factor for the occurrence and development of cardiovascular diseases, particularly in patients receiving thoracic radiotherapy. This exposure leads to oxidative stress and inflammation, which can damage cardiac tissue and vascular endothelium. Molecular hydrogen…