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Studies Found: 1335

ENDOTHELIUM - SURGERY/TRANSPLANTATION

Hydrogen attenuates endothelial glycocalyx damage associated with partial cardiopulmonary bypass in ...

Year Published: 2023

Cardiopulmonary bypass (CPB) causes systemic inflammation and endothelial glycocalyx damage. Hydrogen has anti-oxidant and anti-inflammatory properties; therefore, we hypothesized that hydrogen would alleviate endothelial glycocalyx damage caused by CPB. Twenty-eight male Sprague-Dawley rats were randomly divided into four groups (n = 7 per group), as follows: sham, control, 2% hydrogen, and 4% ...
LUNG - INTERSTITIAL LUNG DISEASE

Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease: A ...

Year Published: 2023

Purpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy was investigated to determine whether it is superior to N-Acetylcysteine (NAC) for the treatment of patients with early-stage ILD. Patients and methods: A prospective, single-center, randomized, controlled clinical trial was ...
BRAIN - CHRONIC FATIGUE SYNDROME

Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four ...

Year Published: 2024

No abstract available
LIVER - FATTY LIVER DISEASE (ALCOHOLIC)

Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate ...

Year Published: 2023

Alcoholic liver disease (ALD), which is induced by chronic heavy alcohol consumption, accompanies complicated pathological mechanisms, including oxidative stress, inflammation, cell death, epigenetic changes and acetaldehyde-mediated toxicity. Hydrogen (H2) is the lightest gas with multiple biological effects such as high selective anti-oxidation, anti-inflammation and anti-apoptosis. However, the ...
PREGNANCY - GUT MICROBIOME

Fructooligosaccharide feeding during gestation to pregnant mice provided excessive folic acid ...

Year Published: 2023

Fructooligosaccharide (FOS) is fermented by intestinal microbes to generate intestinal microbe-derived hydrogen gas (IMDH). Oxidative stress increases during gestation, whereas hydrogen gas has antioxidant effects with therapeutic benefits. We have previously reported that the offspring from a pregnant, excessive folic acid mouse model (PEFAM) had abnormal glucose metabolism after growth. We ...
WHOLE BODY - IMMUNE REGULATION

NIR-Activatable Heterostructured Nanoadjuvant Cop/Nicop Executing Lactate Metabolism Interventions ...

Year Published: 2023

Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic non-invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation severely limits its clinical outcomes. Although several metabolic interventions have been devoted to ameliorate immunosuppression, intracellular residual LA still remains a potential energy ...
LUNG - SEPSIS

Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by ...

Year Published: 2023

Background: Sepsis is a type of life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The lung is the most vulnerable target organ under septic conditions. Pulmonary microvascular endothelial cells (PMVECs) play a critical role in acute lung injury (ALI) caused by severe sepsis. The impairment of PMVECs during sepsis is a complex regulatory process ...
LUNG - SARS/COVID

The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant ...

Year Published: 2023

Clinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed to explore the efficacy of hydrogen/oxygen therapy in favoring the recovery of Omicron SARS-CoV-2 variant infection. There were 64 patients who randomly assigned to receive hydrogen/oxygen inhalation (32 patients) and ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A ...

Year Published: 2023

Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and chronic respiratory failure. This study aims to determine if hydrogen-rich water (HRW) can enhance oxygen saturation among patients with chronic lung diseases. Methods: Ten patients with chronic lung diseases due to COPD (n = 7), ...
BRAIN - RADIOPROTECTION

Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism ...

Year Published: 2023

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by coupling the brain metabolomics and biological target network methods. Methods and results: HRW significantly improves the cognitive impairment in rats exposed to ionizing ...
BRAIN - STROKE

Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the ...

Year Published: 2023

This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on neurological function in mice with cerebral ischemia were evaluated by neurological function scores. Infarct volume and histological damage were evaluated by 2,3,5‑triphenyl tetrazolium chloride staining (TTC staining). Golgi‑Cox ...
EYE - RETINAL INJURY

Inhibition of retinal ischemia-reperfusion injury in rats by inhalation of low-concentration ...

Year Published: 2023

Purpose: To investigate the inhibitory effect of hydrogen gas inhalation on retinal ischemia reperfusion (I/R) injury using a rat model. Methods: Six-week-old male Sprague-Dawley rats were used. A 27G needle connected by a tube to a saline bottle placed 200 cm above the eye was inserted into the anterior eye chamber to create a rat retinal I/R model. In the ischemia-plus-hydrogen-gas group (H2( +) ...
EYE - RETINAL INJURY

The clinical research on the effect of hydrogen-rich water on primary retinitis pigmentosa

Year Published: 2023

Objective: To investigate the feasibility and effectiveness of hydrogen in the treatment of retinitis pigmentosa (RP) patients through the drinking of hydrogen-rich water (HRW). Methods: RP patients clinically diagnosed in our hospital were selected and given HRW for drinking at 400-500 ml twice a day for four consecutive weeks. Changes in best corrected visual acuity (BCVA), intraocular pressure, ...
OVARIES - POLYCYSTIC OVARY SYNDROME

The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Year Published: 2023

Research question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Design: Female rats were divided into four groups, each consisting of eight animals. The control group received a carboxymethyl cellulose (CMC) solution, the molecular hydrogen (H2) group was given hydrogen-rich water and a CMC solution, the PCOS group was administered letrozole dissolved in ...
WHOLE BODY - SEPSIS

Micromotor-Enabled Active Hydrogen and Tobramycin Delivery for Synergistic Sepsis Therapy

Year Published: 2023

Sepsis is a highly heterogeneous syndrome normally characterized by bacterial infection and dysregulated systemic inflammatory response that leads to multiple organ failure and death. Single anti-inflammation or anti-infection treatment exhibits limited survival benefit for severe cases. Here a biodegradable tobramycin-loaded magnesium micromotor (Mg-Tob motor) is successfully developed as a ...
EAR - CANCER

Hydrogen–oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with ...

Year Published: 2019

Three patients with nasopharyngeal carcinoma developed binaural secretory otitis media 12, 2, and 0.5 years after radiotherapy, respectively. The secretions subsided after conventional drug and drainage treatments, but hearing continued to deteriorate until severe loss was documented in both ears. After examination of the eardrum and tympanum, patients were enrolled in a clinical trial in the ...
MUSCLE - DISUSE ATROPHY

Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse ...

Year Published: 2023

Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial. This study aimed to investigate the therapeutic potential of hydrogen-rich water (HRW) on muscle atrophy in a unilateral hind limb immobilization model. Thirty-six male Balb/C mice were divided into control ...
HEART - CHRONIC HEART FAILURE

Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart ...

Year Published: 2023

We studied the effect of molecular hydrogen H2 on the content of circulating endothelial cells and the macrohistological structure of the heart in rats with simulated chronic heart failure. Inhalation with 2% H2 was carried out repeatedly (40 min per day for 5 consecutive days) or once (40 min). Molecular hydrogen inhalations in both regimens caused a decrease in the number of circulating ...
LIVER - CANCER

Investigating the Effect of Hydrogen-Rich Water on Liver Cell Injury and Liver Cancer by Regulating ...

Year Published: 2021

Background Liver cancer is an extremely heterogeneous malignant disease among tumors identified to date. In recent years, a large number of studies have found that low-concentration hydrogen or hydrogen-rich water or hydrogen-saturated physiological saline has a protective effect on many diseases. Observing the intervention effect of hydrogen-rich water and speculate whether its effect is ...
UTERUS - CANCER

RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via ...

Year Published: 2020

Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in DMEM medium with or without hydrogen. RNA sequencing was used to explore the association of hydrogen treatment with signaling pathways and functional genes in endometrial cancer cells. The apoptotic rates of the three ...
WHOLE BODY - METABOLIC SYNDROME

Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium ...

Year Published: 2023

Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments ...
INTESTINE - OBESITY

Hydrogen-rich water upregulates fecal propionic acid levels in overweight adults

Year Published: 2023

Fecal short-chain fatty acids are responsive to oral hydrogen in overweight adults. Propionic acid significantly increased in participants who consumed hydrogen-rich water for 12 wk compared with those who consumed tap water. This finding holds potential significance in addressing metabolic dysregulation.
LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and ...

Year Published: 2023

Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increased fat accumulation in liver tissue caused by factors other than alcohol consumption. Platelet mitochondrial function is considered to reflect systemic mitochondrial health. We studied the effect of adjuvant ...
LUNG - AGING

Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through ...

Year Published: 2023

Introduction: With the global population aging, there is an increased prevalence of sepsis among the elderly, a demographic particularly susceptible to inflammation. This study aimed to evaluate the therapeutic potential of hydrogen gas, known for its anti-inflammatory and antioxidant properties, in attenuating inflammation specifically in the lungs and liver, and age-associated molecular markers ...
HEART - HEART FAILURE

Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via ...

Year Published: 2023

Aims: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively and alleviate the inflammatory response in the myocardial ischaemia/reperfusion (I/R) injury, but the underlying mechanism has not been fully clarified. Methods and results: Adult (10 weeks) C57BL/6 male mice ...