Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

Atsunori Nakao, Chein-Sheng Huang, Ki-Mun Kang, Takenori Yamashita, Torao Ishida, Tota Inoue, Yeunhwa Gu

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DOI: 10.3164/jcbn.10-19 DOI is the universal ID for this study.

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Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations using senescence-accelerated prone mouse 8 (SAMP8), which exhibits early aging syndromes including declining learning ability and memory. However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability seen in SAMP8 as assessed by a water maze test and was associated with increased brain serotonin levels and elevated serum antioxidant activity. In addition, drinking hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, while marked loss of neurons was noted in control, aged brains of mice receiving regular water. On the basis of our results, hydrogen water merits further investigation for possible therapeutic/preventative use for age-related cognitive disorders.

Publish Year 2010
Country Japan
Rank Positive
Journal Journal of Clinical Biochemistry and Nutrition
Primary Topic Brain
Secondary TopicAging
Model Mouse
Tertiary TopicCognitive Impairment
Vehicle Water (Mg-Chemico)
pH Alkaline
Application Ingestion