All Studies
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Molecular hydrogen in cancer therapy: Bioactive materials for tumor-targeted delivery and in situ generation
Molecular hydrogen (H2) therapy has emerged as a promising adjunctive strategy in oncology, primarily attributed to its selective antioxidant, anti-inflammatory, and cytoprotective properties. Advances have been driven by the integration of mechanistic studies on H2-mediated redox regulation…
Inhalation of hydrogen gas reduces exacerbations of acute aortic dissection in mice
Aims: Acute aortic dissection (AAD) is a life-threatening condition in which vascular inflammation contributes to disease progression and complications such as aortic rupture. Current treatment is centered on hemodynamic control, and anti-inflammatory options remain limited. We investigated whether…
Longitudinal In Vivo Immunophenotyping of Regulatory T Cells Following Adjunctive Molecular Hydrogen Therapy in Systemic Lupus Erythematosus
Background/aim: Regulatory T cells (Tregs) are pivotal for maintaining immune tolerance, yet their dynamic changes during the transition from active disease to remission in systemic lupus erythematosus (SLE) remain unclear. We assessed whether specific Treg subpopulations can serve as biomarkers…
IBS and SIBO: Gut Microbiota, Pathophysiology, and Non-Pharmacological Interventions
Irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) share symptoms such as abdominal pain, bloating, and altered bowel habits. Both are linked to dysbiosis and gut-brain axis dysfunction. IBS is a multifactorial disorder characterized by abnormal motility, visceral…
Efficacy of silicon-based agent against aging-related frailty
Increasing aging populations globally have made maintaining a healthy life expectancy for older adults a critical issue. Older adults are particularly susceptible to frailty, physical and mental vulnerability caused by age-related decline in physiological and psychological resilience. Preventing…
Paradigm shift in hydrogen medicine: Target molecules and catalytic mechanisms elucidated at the atomic level
Molecular hydrogen (H2) has been shown to exert antioxidant and anti-inflammatory effects across a broad spectrum of disease models and clinical trials; however, its direct reaction rate with hydroxyl radicals (•OH) in aqueous solution is exceedingly slow, and the underlying mechanism of action has…
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice
Molecular hydrogen (H2) exhibits anti-inflammatory and antioxidant properties. However, its role in ultraviolet B (UVB)-induced skin carcinogenesis remains unclear. Male HR-1 hairless mice received continuous H2 (2% hydrogen gas inhalation plus hydrogen-rich water (HRW)) or control treatment…
Hydrogen treatment attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway
Purpose: Spinal cord ischemia-reperfusion injury (SCIRI) can lead to significant losses in sensory and motor functions. The precise role of hydrogen (H2) as an antioxidant in the process of ferroptosis is not fully determined. Materials and methods: This study used an abdominal aorta ligation…
Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel?
A recent study published in Redox Biology (Volume 88, December 2025, 103952) demonstrates that molecular hydrogen (H2) rapidly suppresses mitochondrial Complex III activity through a mechanism involving the Rieske iron-sulfur protein (RISP) and subsequent LONP1-dependent proteolysis, challenging…
Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report
Background/aim: Rhupus syndrome, an overlap of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), is a rare condition characterized by heterogeneous clinical manifestations and difficult management. Conventional therapies, including glucocorticoids, disease-modifying anti-rheumatic…
Hydrogen Nanobubbles Inhibit Oxidative Stress and Myocardial Fibrosis to Reverse Chemotherapy-Induced Myocardial Injury
The most severe side effect of chemotherapy is cardiotoxicity, frequently causing myocardial injury characterized by excessive oxidative stress and fibrosis for which effective treatments are lacking. To address this, a hydrogen delivery system, hydrogen nanobubbles (HNBs), was constructed…
The Protective Effects of molecular Hydrogen in Sepsis-associated Encephalopathy: current status
Sepsis-associated encephalopathy (SAE) is a severe neurological complication that arises in patients with sepsis, characterised by cognitive impairment and neurological dysfunction. Mechanisms contributing to SAE include oxidative stress, inflammation, mitochondrial dysfunction, and blood-brain…
Inflamed vessel–anchored release of H <sub>2</sub> across the blood-brain barrier for ischemic stroke neuroprotection
Ischemic stroke followed by reperfusion urgently requires safe and efficient cytoprotective strategies, a need still unmet by current pharmacotherapies. Nanotechnology holds promise for improved drug delivery to the brain, yet the efficacy of nanomaterials crossing the blood-brain barrier (BBB)…
Safety and efficacy of a novel fecal microbiota transplantation method using hydrogen nanobubble water without antibiotics or bowel cleansing in children with autism spectrum disorder: an open-label, single-arm study demonstrating improvements in core and comorbidity symptoms
Background Autism spectrum disorder (ASD) is rising in prevalence, but effective treatments for its core symptoms remain limited. Fecal microbiota transplantation (FMT) has shown promise; however, conventional methods often require antibiotics and bowel cleansing, raising concerns regarding safety…
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality and limited effective pharmacotherapies. Accumulating evidence has established mitochondrial dysfunction as a central pathogenic hub in ARDS. Injured mitochondria exhibit excessive reactive oxygen species…
Molecular hydrogen is associated with immunophenotypic modulation and changes in T-cell exhaustion markers in refractory primary Sjögren's syndrome-associated interstitial lung disease: A case report
Sjögren's syndrome-associated interstitial lung disease is a severe systemic complication that often proves refractory to conventional immunosuppressive and biologic therapies. Molecular hydrogen has recently emerged as a novel therapeutic agent known for its selective antioxidant…
Dual-wavelength-responsive GMMC-Pdots-Ag hydrogel for spatiotemporally controlled photothermal and hydrogen therapy of infected liver and skin defects
An innovative dual-wavelength-responsive GMMC-Pdots-Ag hydrogel was fabricated for the treatment of polymicrobial-infected liver and skin defects. The hydrogel is based on a dynamic double-network architecture composed of gelatin methacryloyl (GelMA), O-carboxymethyl chitosan (O-CMC), and 4-arm…
Generation and Application of Ultra-Fine, Long-Term Stable Nanobubble Water: An Evaluation of Inclusion Effects on Aromatic Components and Antimicrobial Activity
Nano- and pico-bubble water (NPB), containing hydrogen or ozone, is widely used as a cleaning agent due to its bactericidal and antiviral properties. However, some products-such as certain hydrogen waters-contain only large bubbles or have an extremely low bubble count, making them sometimes…
Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes
Effects of Hydrogen-Rich Water Supplementation on Exercise Performance, Autonomic Nervous System Recovery, and Blood Lactate Concentration During Repeated Sprint Exercise in Male University Athletes
Ag‐Decorated Hydrogen Molybdenum Bronze Nanotubes as Dual‐Action Agents Against <i>Bacillus subtilis</i> : Experimental and Theoretical Insights Into Membrane Damage and Protein Interference
Bacterial biofilms are a persistent challenge in industrial settings such as water treatment and food processing, contributing to antimicrobial resistance, operational inefficiencies, and environmental burden. Here, we report on the synthesis and multiscale evaluation of hydrogen molybdenum bronze…