All Studies

The Gastroprotective Effect of Hydrogen-Rich Coral Calcium in a Mouse Model of Peptic Ulcer Disease

Introduction: Peptic ulcer disease (PUD), including gastric and duodenal ulcers, is primarily caused by Helicobacter pylori infection and non-steroid anti-inflammatory drugs, with additional contributors like stress, certain foods, and alcohol. Proton pump inhibitors (PPIs) are effective but…

Hydrogen intervention attenuates chronic hypoxia-induced bone degeneration and multi-organ damage via modulation of the gut microbiota

High-altitude hypoxia disrupts bone metabolic homeostasis and accelerates bone loss. However, effective strategies for preventing and treating hypoxia-induced osteoporosis remain limited. This study aimed to evaluate the protective effects of hydrogen-rich water (HRW) and coral calcium hydride…

Molecular Hydrogen in the Treatment of Respiratory Diseases

Molecular hydrogen is gaining increasing attention as an antioxidant, anti-inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current therapeutic potential among others in inflammatory diseases, cancer, and sports medicine, among others. The present review aims…

Hydrogen inhalation: a potential treatment for radiotherapy/chemotherapy-induced hearing loss in cancer patients

Hemodialysis employing molecular hydrogen (H2) enriched dialysis solution may improve dialysis related fatigue through impact on energy metabolism

Hemodialysis employing molecular hydrogen (H2)-enriched dialysis solution rendered by water electrolysis (E-HD), has been reported to alleviate dialysis-related fatigue, but its association with metabolic profiles remains unclear. Eighty-one patients undergoing standard HD were classified into 3…

Multifunctional Responsive Gas-Releasing Metal Organic Framework Nanoplatform for Tumor Therapy Application

Gas therapy (GT), which regulates the tumor microenvironment by releasing therapeutic gas molecules (e.g., O2, NO), has taken an innovative direction in tumor therapy. However, conventional gas-releasing molecules (GRMs) suffer from core problems such as uncontrollable release, poor targeting…

Hydrogen Incorporation Selectively Modulates the Catalytic Performance of Pd Nanozymes for Cascade-Catalytic Tumor Therapy

Pd-based nanozymes have emerged as promising alternatives to natural enzymes, but their application is still constrained due to suboptimal activity and poor specificity. As efficient hydrogen storage nanomaterials, the specific implications of implanted hydrogen on the enzyme-mimicking activity…

Gas-based therapeutics and delivery platforms in cancer immunotherapy

Gas-based therapeutics are emerging as a promising strategy in cancer immunotherapy. Small gaseous signaling molecules such as nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and oxygen (O2) efficiently penetrate tumor tissues and modulate diverse immune pathways. These therapeutic…

Gas Therapies for Neuro-Protection

Cardiac arrest (CA) remains a major cause of mortality and neurologic impairment, underscoring the urgent need for innovative neuroprotective strategies. Gas therapies, including inhaled nitric oxide (NO), molecular hydrogen (H2), xenon (Xe), and argon (Ar), have emerged as promising…

Comparison of the Antimicrobial Effect of Hydrogen Water and Chlorhexidine Mouth rinse in Toothbrush Disinfection Among Dental Students

Background: Toothbrushes are essential for eliminating dental biofilm and preventing caries and periodontal disease. Regular disinfecting is necessary to maintain a clean toothbrush. Chlorhexidine is the gold standard, but it may be resistant to periodontal pathogens. Hydrogen-rich water, due…

Metal-based micro/nanomaterials for hydrogen therapy and their biomedical applications

Hydrogen therapy, as an emerging and promising therapeutic strategy, utilizes the ability of hydrogen to selectively scavenge reactive oxygen species, exerting biological effects such as antioxidant, anti-inflammatory, anti-tumor and antibacterial, and showing significant therapeutic effects…

Influence of hydrogen-rich water on spermatogenesis and sperm parameters in experimentally induced hypothyroidism and subclinical hypothyroidism models

Hypothyroidism, characterized by insufficient thyroid hormone production, disrupts metabolic processes and impairs reproductive function. It is suggested that oxidative stress plays a key role in mediating the deleterious effects of hypothyroidism on testicular function and because…

Unlocking the Untapped Potential of Photoresponsive Dual-Gas Nanomedicine in Glaucoma Therapy

Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by optic nerve damage often associated with elevated intraocular pressure (IOP). Although gas therapies hold promise for glaucoma treatment, the limitations of single-gas strategies constrain their therapeutic efficacy…

RNA-Seq Reveals the Mechanism of Synergistic Hydrogen-Chemotherapy Based on Active Magnesium Micromotors for Inhibiting Glioblastoma Recurrence by Modulating Tumor Microenvironment

Postoperative recurrence of glioblastoma (GBM) is a key contributing factor to the unfavorable prognosis of patients. Chemotherapy has been extensively employed as a postoperative treatment for GBM; however, the produced drug resistance significantly undermines the chemotherapeutic efficacy…

Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis

Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing…

Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report

Background/aim: Pericarditis is a common cardiovascular complication associated with systemic lupus erythematosus (SLE). Oxidative stress plays a significant role in disease pathology. Molecular hydrogen has emerged as a promising therapeutic option with its antioxidant, anti-inflammatory…

Effectiveness of using non-drug technologies to increase stress resistance in persons with extreme work profile and susceptible for professional burnout

The high prevalence of professional burnout syndrome among medical workers significantly actualizes the search for the most effective methods aimed at reducing the severity of the negative consequences of professional stress. A certain perspective in solving this problem is associated…

A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people

Abstract Disruption of hydrogen (H 2 ) cycling in the gut is linked to gastrointestinal disorders, infections and cancers. However, the mechanisms and microorganisms controlling H 2 production in the gut remain unresolved. Here we show that gut H 2 production is primarily driven by the microbial…

Hydrogen: an advanced and safest gas option for cancer treatment

Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review

Heart failure (HF) is increasing in prevalence in many countries around the world. HF is a complex clinical syndrome characterized by the heart's inability to pump blood effectively, resulting in significant morbidity and mortality. After an initial cardiac event (e.g., myocardial infarction, valve…