Multifunctional Responsive Gas-Releasing Metal Organic Framework for Tumor Therapy
Multifunctional Responsive Gas-Releasing Metal Organic Framework Nanoplatform for Tumor Therapy Application
- Evidence type
- Review or commentary
- Authors
- Yue Meng, Jing Lu, Xiangwei Liu, Ruixuan Liu, Ding Dai, Yuan Sun, Tiedong Sun
- Journal
- ChemMedChem
- Year
- 2025
- PMID
- 40875284
- Study Type
- clinical
- Peer Reviewed
- Yes
- Cited by
- 5 (OpenAlex, as of November 2026)
- Country
- China
TL;DR
Scientists created tiny containers made of metal and organic materials that can store and release healing gases (like oxygen) directly into tumors to fight cancer more effectively. This new approach is better than old methods because it releases the gas exactly where and when it's needed, making cancer treatment safer and more powerful.
Summary
Researchers created innovative metal-organic framework (MOF) nanoparticles that can deliver therapeutic gases including hydrogen, oxygen, and nitric oxide directly to cancer tumors. These smart nanoparticles have high surface area and adjustable pores that allow precise control over gas storage and release. Unlike conventional gas therapy methods that suffer from poor targeting and uncontrolled release, MOF-based platforms offer superior stability and can respond to specific tumor conditions. This breakthrough addresses major limitations in gas therapy and represents a promising new approach for safer, more effective cancer treatment through controlled delivery of therapeutic gases.
Abstract (excerpt)
Gas therapy (GT), which regulates the tumor microenvironment by releasing therapeutic gas molecules (e.g., O2, NO), has taken an innovative direction in tumor therapy. However, conventional gas-releasing molecules (GRMs) suffer from core problems such as uncontrollable release, poor targeting…