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Magnesium Structure-Function Integration Platform for Spatiotemporal Multi-Modality Therapy: Combining Hormonotherapy and Immunotherapy in Prostate Cancer
Metal-based immunotherapy represents a promising strategy for enhancing antitumor efficacy; however, its clinical application is limited by challenges such as inefficient drug delivery, low specificity, and suboptimal therapeutic outcomes. In this study, a therapeutic platform is constructed…
Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction-associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis
BackgroundHydrogen gas (H2), which is the lightest and diffusible gas molecule, has strong abilities to alleviate excessive oxidative stress, inflammation, and apoptosis. Inhalation of H2 is beneficial for preventing the damage of the lung, heart, brain, liver, kidneys, and many other organs…
Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice
Objectives: As a known antioxidant, hydrogen has been useful for treating pressure ulcers. However, conventional methods of hydrogen administration have limitations with regard to dosage and continuity of hydrogen intake. This study evaluated the efficacy of a novel Si-containing agent that can…
Nanoquadruplex-driven hydrogen therapy: NIR-controlled release for targeted cancer ferroptosis
Hydrogen therapy as an emerging strategy for anticancer medicine is attracting attention. However, the limitations of effective hydrogen storage and release have hindered its development and application for hydrogen therapy. Herein, a high hydrogen storage nanoquadruplex (PdH0.2)4Se based…
Nano-Bubble Hydrogen Water in Wet-Wrap Dressing Improves the Severity of Pediatric Patients With Atopic Dermatitis
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition in which reactive oxygen species (ROS) contribute to its pathogenesis. Hydrogen water (HW), with potent antioxidant properties, may counteract ROS and improve AD symptoms. This study assessed the clinical efficacy…
Hydrogen water versus normal saline for post-surgical irrigation: A study on healing and complication rates after third molar extraction
Oral surgery involving impacted mandibular third molars is a common procedure. However, it results in postoperative complaints such as pain, swelling, trismus and dry socket. Therefore, it is of interest to compare hydrogen water and normal saline as surgical irrigants in patients undergoing third…
Preventing Cisplatin-Induced Neuropathy and Related Emotional Disorders with the Coadministration of Duloxetine and Hydrogen-Rich Water in Male and Female Mice
Cisplatin (CIS)-induced peripheral neuropathy and associated comorbidities have a detrimental effect on the lives of cancer patients. Currently, there are no effective therapies to alleviate these symptoms. Duloxetine (DULO) is a recommended treatment, but it is linked with important side effects…
Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights
Hydrogen-rich water (HRW) has shown neuroprotective effects in acute brain injury, but its role in chronic radiation-induced brain injury (RIBI) remains unclear. This study investigated the long-term efficacy of HRW in mitigating cognitive impairment and neuronal damage caused by chronic RIBI…
Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report
Background/aim: Pericarditis is a common cardiovascular complication associated with systemic lupus erythematosus (SLE). Oxidative stress plays a significant role in disease pathology. Molecular hydrogen has emerged as a promising therapeutic option with its antioxidant, anti-inflammatory…
Molecular hydrogen therapy: A "democratic" emerging strategy against aging and age-related diseases
Aging represents the main risk factor for the development of several diseases, including cardiovascular and metabolic conditions, neurodegenerative disorders and cancer. As the number of elderly people is increasing worldwide, different strategies to counteract age-related diseases have been…
Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models
Alzheimer's disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation…
Effect of hydrogen-enriched water on healing of excisional full-layer skin wounds in diabetic and non-diabetic rats
This study was carried out in an experimental study design with experimental and control groups to investigate the effect of hydrogen-enriched water (HRW) on healing in excisional full-layer skin wounds. The rats were divided into diabetic group (n = 20) and non-diabetic group (n = 18) (n = 38)…
Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing…
Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway
IntroductionAdipose-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative therapies, but their clinical application is limited by cellular aging. This study investigated the effects of hydrogen on ADSC senescence and myogenic differentiation, along with the underlying…
Refined Lactulose Hydrogen Breath Test for Small Intestinal Bacterial Overgrowth Subgrouping Irritable Bowel Syndrome With Low and High Breath Hydrogen
Background: Small intestinal bacterial overgrowth (SIBO) is suggested in irritable bowel syndrome (IBS). Our primary aim was to define a discriminating threshold for a positive lactulose hydrogen breath test (LHBT) in SIBO. As a secondary aim, IBS was subdivided into SIBO and non‐SIBO groups…
Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
Objectives: Acute ischemic stroke caused by internal carotid artery (ICA) occlusion carries high risks of disability and death. While treatments such as thrombolysis, mechanical thrombectomy, and revascularization offer benefits, many patients experience limited recovery. Molecular hydrogen…
In vitro hydrogen production by mammal [FeFe]-hydrogenase-like protein
Although emerging evidence in mammals reveals that exogenously applied H2 positively regulates numerous physiological and pathological responses, it remains unclear whether and how mammalian cells produce H2 endogenously. Here, we report for the first time that recombinant human (Homo sapiens)…
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice
The treatment of osteoporosis and related bone defects remains challenging. This study identifies pyroptosis-driven inflammation as a key disruptor of bone homeostasis. To address this, we develop a magnesium-gelatin composite microsphere scaffold (GelMa/Mg/DMF MS) that exploit pyroptosis blockade…
Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes
Background: Strenuous exercise can lead to exercise-induced lung injury, primarily driven by elevated oxidative stress and systemic inflammation. Although hydrogen (H2) inhalation has been proposed as a nonpharmacological intervention with antioxidant and anti-inflammatory potential, its effects…
Hydrogen gas promotes neuroprotection and upregulates ATF5 expression in neonatal hypoxic-ischemic brain injury
Neonatal brain injury, typically caused by hypoxia-ischemia (HI), results in irreversible cortical and white matter damage, leading to severe neurological sequelae. Therapeutic hypothermia, the only available clinical intervention, has limited effectiveness and is not suitable for all patients…