Hydrogen Gas in Piglets Protects Newborn Brains from Birth Injury
Hydrogen gas promotes neuroprotection and upregulates ATF5 expression in neonatal hypoxic-ischemic brain injury
Research hubs: Brain & Nervous System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (pig)
- Authors
- Shinji Nakamura, Yasuhisa Nakamura, Hideo Jinnou, Yasuhiro Nakao, Htun Yinmon, Tsutomu Mitsuie, Kosuke Koyano, Masaki Ueno, Takanori Miki, Kazunobu Sawamoto, Shinji Saitoh, Takashi Kusaka
- Journal
- Experimental Neurology
- Year
- 2025
- PMID
- 41386344
- Study Type
- Pig
- Delivery
- Gas
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Japan
TL;DR
Hydrogen gas protected brain cells in newborns after oxygen deprivation by reducing cell death, inflammation, and myelin damage.
Key Finding
Hydrogen gas treatment significantly reduced brain cell death and preserved cell survival in newborn piglets with hypoxic-ischemic brain injury, with effects mediated through activation of the anti-apoptotic protein ATF5.
Summary
Researchers studied whether hydrogen gas could protect newborn pig brains from damage caused by lack of oxygen and blood flow (hypoxia-ischemia). They found that hydrogen gas treatment reduced brain cell death in two important cell types—neurons and oligodendrocytes (cells that insulate nerve fibers)—and activated a protective protein called ATF5. The treatment also reduced inflammation and preserved the protective coating around nerve fibers.
Practical Takeaway
This animal study suggests hydrogen gas may have neuroprotective potential for newborn brain injury, but it was conducted only in piglets and has not been tested in human infants. Much more research, including human clinical trials, would be needed before any therapeutic claims could be made. The findings are preliminary and should not be interpreted as evidence that hydrogen gas is an effective treatment for neonatal brain injury in humans.
Abstract (excerpt)
Neonatal brain injury, typically caused by hypoxia-ischemia (HI), results in irreversible cortical and white matter damage, leading to severe neurological sequelae. Therapeutic hypothermia, the only available clinical intervention, has limited effectiveness and is not suitable for all patients…