Hydrogen Water Protects Brain from Radiation Damage in Rats
- Authors
- Kai Xu, Huan Liu, Yinhui Wang, Yushan He, Mengya Liu, Haili Lu, Yuhao Wang, Piye Niu, Xiujun Qin
- Journal
- Antioxidants
- Year
- 2025
- DOI
- 10.3390/antiox14080948
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Radiation-Induced Brain Injury
- Body System
- Nervous System
TL;DR
Drinking hydrogen-rich water may protect the brain from long-term radiation damage by improving memory, reducing inflammation, and supporting nerve cell recovery.
Key Finding
Hydrogen-rich water significantly improved cognitive function, memory, and anxiety-like behavior in rats with chronic radiation-induced brain injury, while also reducing neuronal damage and promoting the growth of new brain connections.
Summary
This study tested hydrogen-rich water in rats that had received high-dose brain radiation to see if it could help prevent long-term brain damage. Rats treated with hydrogen-rich water showed better memory, learning, and anxiety levels compared to untreated irradiated rats. The researchers found that hydrogen-rich water reduced brain cell damage, promoted the growth of new brain connections, and changed the activity of genes and proteins involved in inflammation and brain repair.
Practical Takeaway
This rat study suggests hydrogen-rich water may help protect the brain from radiation damage, but human studies are needed before any conclusions can be drawn about its usefulness for people. The findings are preliminary and based on animal research only, so the effects in humans remain unknown.
Abstract
Hydrogen-rich water (HRW) has shown neuroprotective effects in acute brain injury, but its role in chronic radiation-induced brain injury (RIBI) remains unclear. This study investigated the long-term efficacy of HRW in mitigating cognitive impairment and neuronal damage caused by chronic RIBI. Fifty male Sprague Dawley rats were randomly divided into five groups: control, irradiation (IR), IR with memantine, IR with HRW, and IR with combined treatment. All but the control group received 20 Gy whole-brain X-ray irradiation, followed by daily interventions for 60 days. Behavioral assessments, histopathological analyses, oxidative stress measurements, 18F-FDG PET/CT imaging, transcriptomic sequencing, RT-qPCR, Western blot, and serum ELISA were performed. HRW significantly improved anxiety-like behavior, memory, and learning performance compared to the IR group. Histological results revealed that HRW reduced neuronal swelling, degeneration, and loss and enhanced dendritic spine density and neurogenesis. PET/CT imaging showed increased hippocampal glucose uptake in the IR group, which was alleviated by HRW treatment. Transcriptomic and molecular analyses indicated that HRW modulated key genes and proteins, including CD44, CD74, SPP1, and Wnt1, potentially through the MIF, Wnt, and SPP1 signaling pathways. Serum CD44 levels were also lower in treated rats, suggesting its potential as a biomarker for chronic RIBI. These findings demonstrate that HRW can alleviate chronic RIBI by preserving neuronal structure, reducing inflammation, and enhancing neuroplasticity, supporting its potential as a therapeutic strategy for radiation-induced cognitive impairment.