In Vivo Evaluation of Bioabsorbable Fe-35Mn-1Ag: First Reports on In Vivo Hydrogen Gas Evolution in Fe-Based Implants
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DOI:
10.1002/adhm.202000667
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Abstract:
This work investigates the influence of Ag (1 wt%) on the mechanical properties, in vitro and in vivo corrosion, and biocompatibility of Fe-35Mn. The microstructure of Fe-35Mn-1Ag possesses a uniform dispersion of discrete silver particles. Slight improvements in compressive properties are attributed to enhanced density and low porosity volume. Fe-35Mn-1Ag exhibits good in vitro and in vivo corrosion rate of Fe-35Mn due to an increase in microgalvanic corrosion. Gas pockets, which originate from an inflammatory response to the implants, are observed in the rats after 4 weeks implantation but are undetectable after 12 weeks. No chronic toxicity is observed with the Fe-35Mn-1Ag, suggesting acceptable in vivo biocompatibility. The high corrosion rate of the alloy triggers an increased level of nonadverse tissue inflammatory responses 4 weeks after implantation, which subsequently subsides at 12 weeks. The Fe-35Mn-1Ag displays properties that are suitable for orthopedic applications.| Publish Year | 2020 |
|---|---|
| Country | Australia |
| Rank | Positive |
| Journal | Advanced Healthcare Materials |
| Primary Topic | Whole Body |
| Secondary Topic | Surgery/Transplantation |
| Model | Rat |
| Tertiary Topic | Novel Therapy |
| Vehicle | Gas (Sustained Release) |
| pH | N/A |
| Application | Implantation |
| Comparison | |
| Complement |