All Studies
2,276 studies foundSort & Filter
Hydrogen alleviates cardiac ferroptosis damage under chronic intermittent hypoxia conditions by targeting Nrf2
Objective: Obstructive sleep apnea (OSA) is a common disorder for which comprehensive and effective treatments and interventions have not yet been fully developed. A hallmark of OSA is chronic intermittent hypoxia (CIH), which significantly contributes to the pathogenesis of cardiovascular diseases…
A Pd nanoparticle-loaded nanoscale covalent organic framework to enhance tumor therapy by synergistic hydrogen/photothermal therapy
A covalent organic framework-based PdH0.18@COF has the capacity to affect mitochondrial function by disrupting intracellular redox balance and thus down-regulating the expression of heat shock proteins, thereby enhancing the photothermal therapy.
Antimicrobial Efficacy of Electrolyzed Waters and Chlorine-Based Disinfectants: The Role of pH, Free Chlorine, and Oxidation-Reduction Potential Over Time
This study evaluated the antimicrobial efficacy of electrolyzed water (EW) and chlorine-based disinfectant (CLD) over time, focusing on the impact of pH, free chlorine (FCL), and oxidation–reduction potential (ORP). EW and CLD are commonly used for wound care and surgical instrument disinfection…
Molecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy
Background: Sepsis-associated encephalopathy (SAE) constitutes a major determinant of sepsis-related mortality across acute and survivorship phases. While molecular hydrogen (H₂) exhibits neuroprotective capacities in SAE, its precise mechanistic underpinnings remain unresolved. This study…
Hydrogen gas promotes neuroprotection and upregulates ATF5 expression in neonatal hypoxic-ischemic brain injury
Neonatal brain injury, typically caused by hypoxia-ischemia (HI), results in irreversible cortical and white matter damage, leading to severe neurological sequelae. Therapeutic hypothermia, the only available clinical intervention, has limited effectiveness and is not suitable for all patients…
Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice
Objective: To develop a safe and effective green therapy for triple-negative breast cancer, this study combines hydrogen-rich water with acupuncture point injection, and finds that it can prevent tumor growth and minimize cancer metastasis. Methods: After 21 d of hydrogen rich water injection…
Biochemical markers of stress in medical workers with occupational burnout syndrome and their dynamics in the application of physiotherapeutic factors
Professional burnout syndrome is becoming an increasingly important social and medical problem, as it can occur in almost every third doctor or nurse. This syndrome is based on chronic stress, which provokes the development of a close relationship between the indicators of various psychological…
Hydrogen rescues vascular endothelial cells in obstructive sleep apnea-hypopnea syndrome by modulating nitric oxide
Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a highly prevalent disorder characterized by chronic intermittent hypoxia (IH), which induces severe vascular endothelial dysfunction via oxidative stress and disruption of nitric oxide (NO) homeostasis, thereby elevating…
Hydrogen enhanced photothermal therapy for redox-regulated tumor apoptosis and immune reprogramming
Photothermal-catalysis enables controlled hydrogen release and redox modulation, with applications in biomedical therapy. Despite growing interest in hydrogen therapy, its effects on immune cells within the tumor microenvironment (TME) remain insufficiently elucidated, specifically regarding…
Influence of hydrogen-rich water on spermatogenesis and sperm parameters in experimentally induced hypothyroidism and subclinical hypothyroidism models
Hypothyroidism, characterized by insufficient thyroid hormone production, disrupts metabolic processes and impairs reproductive function. It is suggested that oxidative stress plays a key role in mediating the deleterious effects of hypothyroidism on testicular function and because…
Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial
Background: Physical activity significantly increases the production of reactive oxygen species in the body. Molecular hydrogen has been shown to have safe and effective antioxidant properties on athletes. However, research on elite athletes is scarce. Methods: A randomized, double-blinded…
Metal-based micro/nanomaterials for hydrogen therapy and their biomedical applications
Hydrogen therapy, as an emerging and promising therapeutic strategy, utilizes the ability of hydrogen to selectively scavenge reactive oxygen species, exerting biological effects such as antioxidant, anti-inflammatory, anti-tumor and antibacterial, and showing significant therapeutic effects…
Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing…
Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: A randomized, double-blind, placebo-controlled crossover study
Molecular hydrogen has gained attention for its potential antioxidant, anti-inflammatory, and ergogenic effects. However, its impact on blood oxygen saturation and autonomic cardiac regulation under resting conditions remains unclear. This randomized, double-blind, placebo-controlled crossover…
Effectiveness of using non-drug technologies to increase stress resistance in persons with extreme work profile and susceptible for professional burnout
The high prevalence of professional burnout syndrome among medical workers significantly actualizes the search for the most effective methods aimed at reducing the severity of the negative consequences of professional stress. A certain perspective in solving this problem is associated…
Hydrogen regulates the aryl hydrocarbon receptor, improving bronchopulmonary dysplasia in neonatal rats and RLE-6TN cells exposed to hyperoxia
Introduction: This study investigates the role and underlying mechanism of hydrogen (H₂) in hyperoxia-induced bronchopulmonary dysplasia (BPD), aiming to provide a theoretical foundation for developing effective BPD treatment strategies. Methods: A hyperoxia-induced BPD rat model and a rat type II…
Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage
Aims: Mitochondrial dysfunction is recognized as a central pathological mechanism in subarachnoid hemorrhage (SAH). This study aimed to investigate whether mitophagy serves as a key mechanism by which hydrogen (H 2 ) exerts its antioxidative effects following SAH. Results: Using in vivo (mouse SAH…
Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction
Background/aim: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multi-organ inflammation and damage across multiple organs, typically managed with steroids and immunomodulators. However, prolonged use of these treatments is often associated with significant side…
Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy
Background/aim: Subdural hematomas (SDH), often caused by head trauma, are serious with high mortality and long-term complications. Studies show that molecular hydrogen has neuroprotective effects, such as reducing oxidative stress, inflammation, and cell death. It may also protect mitochondria…
Hydrogen-Rich Water Potentiates Cannabinoid- and Gabapentinoid-Induced Analgesia in Neuropathic Pain
Neuropathic pain (NP) is a complex and disabling condition that often requires long-term treatment with high doses of pharmacological agents, frequently resulting in significant adverse side effects. Therefore, safer and more effective therapeutic approaches are urgently needed. Molecular hydrogen…