All Studies
2,276 studies foundSort & Filter
Hydrogen activated the Nrf2/HO pathway to alleviate the cognitive decline in PD Drosophila after long-term sevoflurane exposure
The demand for surgical and anesthetic care in patients with Parkinson's disease (PD) is projected to increase, because PD is the fastest-growing neurological disorder. Sevoflurane, the most commonly used volatile anesthetic, is neurotoxic to human and animal neonatal brains. Moreover…
Hydrogen rescues vascular endothelial cells in obstructive sleep apnea-hypopnea syndrome by modulating nitric oxide
Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a highly prevalent disorder characterized by chronic intermittent hypoxia (IH), which induces severe vascular endothelial dysfunction via oxidative stress and disruption of nitric oxide (NO) homeostasis, thereby elevating…
The novel hydrogen-PT2385-silncARSR nanocomplex impairs tumor angiogenesis and mitochondrial activity in sunitinib-resistant renal cancer
Hydrogen therapy has emerged as a promising agent for cancer treatment. Earlier research demonstrated that hydrogen (H2) possesses anti-angiogenic effects across multiple tumor types. However, no studies have yet investigated the anti-angiogenic effects of H2 in sunitinib-resistant clear cell renal…
Extra increase in exhaled hydrogen during fructose malabsorption breath tests is linked to additional food intolerance/malabsorption and/or Helicobacter pylori
Background & aims: Food intolerance/malabsorption, including fructose malabsorption (FM), histamine intolerance (HIT), lactose intolerance (LIT), and Helicobacter pylori (H. pylori), may present with symptoms similar to symptoms of the irritable bowel syndrome (IBS) spectrum. We aimed…
Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5-mediated autophagy
Neuropathic pain is a chronic, intractable condition characterized by a complex pathogenesis. Hydrogen-rich water (HRW) has been reported to have possible analgesic properties, but the underlying mechanisms remain unclear. To investigate the effects of HRW, we utilized an L4 spinal nerve ligation…
Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report
Objectives: Acute ischemic stroke caused by internal carotid artery (ICA) occlusion carries high risks of disability and death. While treatments such as thrombolysis, mechanical thrombectomy, and revascularization offer benefits, many patients experience limited recovery. Molecular hydrogen…
Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes
Background: Strenuous exercise can lead to exercise-induced lung injury, primarily driven by elevated oxidative stress and systemic inflammation. Although hydrogen (H2) inhalation has been proposed as a nonpharmacological intervention with antioxidant and anti-inflammatory potential, its effects…
Hydrogen intervention attenuates chronic hypoxia-induced bone degeneration and multi-organ damage via modulation of the gut microbiota
High-altitude hypoxia disrupts bone metabolic homeostasis and accelerates bone loss. However, effective strategies for preventing and treating hypoxia-induced osteoporosis remain limited. This study aimed to evaluate the protective effects of hydrogen-rich water (HRW) and coral calcium hydride…
Chitosan-sodium tripolyphosphate-zinc nanogel for synergistic hydrogen and ion release to eradicate Helicobacter pylori and promote gastric mucosal healing
This study developed a chitosan (CS)‑sodium tripolyphosphate (TPP)‑zinc (Zn) nanogel for treating Helicobacter pylori (H. pylori) through synergistic antibacterial, anti-inflammatory, and mucosal repair mechanisms. The nanogel was synthesized via an emulsion method, leveraging electrostatic…
Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling coupling
The weaker soft tissue integration around implants compared to natural teeth poses a substantial challenge to the long-term success of implants. To enhance soft tissue integration, we develop an on-demand and long-lasting H2-releasing implant to achieve precise sequential regulation of the soft…
Gut microbiota as a central mediator in hydrogen gas-induced alleviation of colitis via TLR4/NF-κB and Nrf2 pathway regulation
Inflammatory bowel disease (IBD) is a chronic and relapsing autoimmune disorder of the gastrointestinal tract with incompletely elucidated pathogenesis and limited therapeutic options. Although hydrogen gas (H₂) has demonstrated therapeutic efficacy in various diseases including IBD, its mechanisms…
Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis
Alzheimer’s disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing a key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment…
Oxidative stress-induced NCC activation in the development of nocturnal polyuria in mice: Therapeutic potential of a sustained hydrogen-releasing silicon-based agent
Nocturnal polyuria is a prevalent condition associated with significant deterioration in quality of life and increased risk of mortality. Despite its clinical relevance, the underlying pathogenesis is poorly understood, and existing therapies have limited efficacy. A recent study in mouse model…
Effect of Si-based agent on alcohol hangovers and liver damage caused by acute ethanol overdose
Excessive alcohol consumption induces hangover symptoms such as headaches, sleep disorders, nausea, cognitive and sensory impairments, depression, and autonomic nervous system dysfunction, as well as liver damage. Additionally, alcohol hangovers cause an altered state of consciousness referred…
Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen's Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats
Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder closely related to stress and traumatic events. Neuroinflammation and synaptic plasticity may play a role in the neurophysiological mechanisms of anxiety-like behaviors in PTSD. In this study, a novel magnesium hydrosilicide…
Effectiveness of using non-drug technologies to increase stress resistance in persons with extreme work profile and susceptible for professional burnout
The high prevalence of professional burnout syndrome among medical workers significantly actualizes the search for the most effective methods aimed at reducing the severity of the negative consequences of professional stress. A certain perspective in solving this problem is associated…
Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial
Background/Objective: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we investigated changes in the intestinal microbiota, therapeutic…
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal
Osteoarthritis (OA), a chronic and degenerative joint disease, has become increasingly prevalent due to the aging population, posing a significant societal burden. However, despite progress, effective therapeutic options for osteoarthritis remain limited. In OA, chronic inflammation mediates…
Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications
The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional…
Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice
Radiation enteritis, affecting over 90% of pelvic/abdominal radiotherapy patients, is primarily caused by radiation-induced reactive oxygen and nitrogen species (RONS). Active hydrogens, with broad-spectrum RONS scavenging ability, show radioprotective potential but face delivery challenges due…