All Studies
2,276 studies foundSort & Filter
Injectable anaerobic hydrogel loading Clostridium butyricum for local hydrogen therapy against colorectal cancer
Hydrogen (H2), a non-toxic therapeutic gas, exerts antitumor effects by disrupting intracellular redox homeostasis and inducing mitochondrial dysfunction. The high diffusibility of H2, as well as its storage difficulties, hinders its sustained release at tumor sites. Thus, the therapeutic effect…
Hydration bioanalyses of the effects of hydrogen-rich water (HRW)
Objective: Aim: To demonstrate the effects of hydrogen-rich water (HRW) on hydration by examining hematocrit, blood viscosity, and urine osmolality. Patients and methods: Materials and Methods: Hydrogen Evodrop rich water (HEW), produced from a patented device with hydrogen concentration therein…
Safety and efficacy of a novel fecal microbiota transplantation method using hydrogen nanobubble water without antibiotics or bowel cleansing in children with autism spectrum disorder: an open-label, single-arm study demonstrating improvements in core and comorbidity symptoms
Background Autism spectrum disorder (ASD) is rising in prevalence, but effective treatments for its core symptoms remain limited. Fecal microbiota transplantation (FMT) has shown promise; however, conventional methods often require antibiotics and bowel cleansing, raising concerns regarding safety…
Protective effects of hydrogen-rich water against acute lead-induced hepatic, renal, and testicular toxicity in rats
Lead exposure is linked to various adverse effects on human health, including toxicity to multiple organs such as the kidneys, liver, and reproductive system. Lead induces its toxic effects through complex pathways, including mitochondrial dysfunction, oxidative stress, and inflammation…
Comparative Efficacy of Coral Calcium Carried Hydrogen versus Dexamethasone in a Mouse Model of Allergic Contact Dermatitis
Introduction Allergic contact dermatitis (ACD) is a common T cell-mediated delayed hypersensitivity reaction characterized by chronic skin inflammation. Coral calcium carried hydrogen (CCH), a novel solid-phase hydrogen carrier, enables sustained hydrogen release and demonstrates superior stability…
Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial
Background: Acute high-intensity exercise induces transient inflammatory and oxidative stress responses, mediated by redox-sensitive signaling pathways and reflected by elevations in interleukin-6 (IL-6) and lipid peroxidation products. Modulation of these responses through hydration-based redox…
Hydrogen-rich jelly exhibits a positive effect on heart rate variability during orthostatic loading in healthy adults: a randomized crossover trial
Hydrogen gas may improve autonomic regulation. The effects of hydrogen-rich jelly (HRJ) on autonomic responses during postural transition have not yet been investigated. This double-blind, randomized, placebo-controlled crossover trial evaluated HRJ effects on heart rate variability (HRV) in 50…
A randomized controlled double-blind study on the brain protection of infantile patients with epileptic spasm syndrome through atomized inhalation of hydrogen-oxygen gas
Objective Hydrogen-oxygen nebulization inhalation has a brain-protective effect. This study aims to evaluate its short-term efficacy and safety as an adjuvant treatment for infantile epileptic spasms syndrome (IESS). Methods A prospective randomized double-blind controlled trial enrolled 53 IESS…
Critical Review: The Past, Present, and Future of Small Intestinal Bacterial Overgrowth (SIBO)
Small intestinal bacterial overgrowth (SIBO) has evolved from a severe debilitating illness to a clinical spectrum associated with abnormalities of microbial populations in the small intestine. It is best described as a pathophysiological state that may contribute to symptoms or other pathology…
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy
ABSTRACT Objective Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study developed a hydrogen‐enriched hyaluronic acid (HA) dressing and aimed to explore its therapeutic effects and mechanisms in DFU treatment. Methods A combination of vacuum‐assisted…
Metabolomic Alterations Associated with Adjunctive Hydrogen Gas Inhalation During Concurrent Chemoradiotherapy in Locally Advanced Head and Neck Cancer: A Pilot Study
Background: H2 gas inhalation has been proposed as a selective modulator of reactive oxygen species (ROS), potentially mitigating treatment-related oxidative damage. This study investigated the effects of adjunctive H2 gas inhalation on serum metabolomic profiles and clinical toxicities in patients…
Hydrogen Production Dynamics During Lactulose Breath Testing in Patients with Suspected SIBO
Background: Small intestinal bacterial overgrowth (SIBO) is characterized by excessive microbial colonization of the small intestine and is commonly diagnosed using hydrogen breath tests. However, most studies focus primarily on diagnostic thresholds rather than the overall dynamics of hydrogen…
Molecular hydrogen is associated with immunophenotypic modulation and changes in T-cell exhaustion markers in refractory primary Sjögren's syndrome-associated interstitial lung disease: A case report
Sjögren's syndrome-associated interstitial lung disease is a severe systemic complication that often proves refractory to conventional immunosuppressive and biologic therapies. Molecular hydrogen has recently emerged as a novel therapeutic agent known for its selective antioxidant…
Mitigation of Ischemia-Reperfusion Injury and Improvement in Overall Graft Viability by Hypothermic Pulsatile Perfusion with Molecular Hydrogen Is Associated with Trx-1/HO-1 Activation in a Non-Survival Ex Vivo Swine Model of Donation-After-Circulatory-Death Kidney Preservation and Transplantation
Despite their reduced viability, kidneys from donors-after-circulatory-death (DCD) increase the pool of transplantable kidneys. Molecular hydrogen (H2) is emerging as a gas with therapeutic potential against graft injury. We investigated the effect of H2 in an ex vivo porcine model of DCD kidney…
Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock-A Proof-of-Concept Study
Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for hemorrhagic shock in the torso has become increasingly common as a bridge to definitive hemostasis. Hydrogen molecules, distributed throughout the bloodstream, alleviate ischemic injury but cannot reach…
An injectable hydrogen-producing bacteria hydrogel for cardiac repair in rodent and porcine models
Cardioprotective effects of current therapies for mitigating ischaemia/reperfusion (I/R) injury have had limited success. The major challenge is to effectively control oxidative stress while preserving mitochondrial function in a timely manner. Hydrogen (H2) selectively reduces cytotoxic oxygen…
Adjuvant Molecular Hydrogen Facilitates Immunosuppressant Tapering and Sustained Remission in Systemic Lupus Erythematosus: A Case Report
Background/aim: Management of systemic lupus erythematosus (SLE) remains challenging: intensive immunosuppression increases infection risk, whereas dose reduction may trigger disease flares. Molecular hydrogen (H2), a selective antioxidant with anti-inflammatory properties, may serve as an adjunct…
Interstitial Cystitis and Dietary Interventions: A Systematic Review
Introduction and hypothesis: Interstitial cystitis/bladder pain syndrome (IC/BPS) is prevalent and disrupts daily life. Dietary modification is commonly recommended, but evidence is fragmented. We systematically compared dietary interventions; we hypothesized that individualized elimination may…
Age differences in overnight breath hydrogen dynamics and their association with sleep physiology
Oxidative stress increases with aging and may influence both sleep physiology and gut microbial activity. Molecular hydrogen, produced by intestinal fermentation, acts as an endogenous antioxidant and can be measured noninvasively in exhaled breath. However, age- and sex-related differences…
Hydrogen therapy and cardiovascular diseases: a visualization analysis of research hotspots and application prospects
Hydrogen, an emerging medical gas, has demonstrated diverse biological effects, including anti-oxidant, anti-inflammatory, and anti-apoptotic activities, offering significant therapeutic potential in cardiovascular diseases. This study aimed to explore the applications of hydrogen therapy…