Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats

Hiroki Tanabe, Naomichi Nishimura, Shuhachi Kiriyama, Tatsuro Yamamoto, Yumi Sasaki

Read more:

DOI: 10.12938/bmfh.31.103 DOI is the universal ID for this study.

This link will take you to the full study.


We examined whether feeding high hydrogen generating resistant starch could suppress subacute hepatic ischemia-reperfusion injury. Rats were fed a control diet with or without 20% high amylose cornstarch (HAS) supplementation for 14 days. On day 12, rats were subject to ischemia-reperfusion treatment. Portal hydrogen concentration was higher in the HAS group compared with the control group. Increased plasma alanine and aspartate aminotransferase activities due to ischemia-reperfusion treatment tended to decrease, and a significant reduction was observed by HAS feeding when compared with the control group. In conclusion, HAS, which enhances hydrogen generation in the hindgut, alleviated subacute hepatic ischemia-reperfusion injury.

Publish Year 2012
Country Japan
Rank Positive
Journal Bioscience of Microbiota, Food and Health
Primary Topic Liver
Secondary TopicSurgery/Transplantation
Model Rat
Tertiary TopicIschemia-Reperfusion Injury
Vehicle Gas
pH N/A
Application In Vivo Biotic Production