Hydrogen and Magnesium Combo in Brain Hemorrhage in Rats
Physiological effects of combination therapy of intracisternal infusion of magnesium sulfate solution and intravenous injection of hydrogen-enriched fluid in the rat
Research hubs: Brain & Nervous System · Cardiovascular System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (rat)
- Authors
- Satoshi Tomura, Kazuya Fujii, Hideaki Ueno, Arata Tomiyama, Naoki Otani, Hideo Osada, Kojiro Wada, Kentaro Mori
- Journal
- Journal of the National Defense Medical College
- Year
- 2014
- Study Type
- Rat
- Delivery
- Saline (Dissolved)
- Dose
- intravenous injection of hydrogen-enriched fluid
- Duration
- 1 day or less
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Japan
TL;DR
A combination treatment using magnesium and hydrogen-enriched fluids was safe and did not negatively affect the vital signs or body functions of rats, even after a brain hemorrhage.
Key Finding
Combination therapy with intracisternal magnesium sulfate and intravenous hydrogen-enriched fluid produced no adverse effects on physiological parameters (blood gases, intracranial pressure, blood pressure, temperature) in rats.
Summary
Researchers tested a combination treatment in rats that involved injecting magnesium sulfate directly into the fluid surrounding the brain and giving hydrogen-enriched fluid intravenously (through the vein). They measured whether this treatment affected important body functions like blood oxygen levels, brain pressure, blood pressure, and temperature in both healthy rats and rats with a type of brain injury called subarachnoid hemorrhage. The treatment did not cause any harmful changes to these physiological measurements or visible damage to brain tissue.
Practical Takeaway
This rat study suggests the combination treatment is physiologically safe and does not harm normal body functions, which is a necessary first step before testing in humans. However, this is an early-stage animal study that only examined safety, not whether the treatment actually works to prevent brain injury in people. Much more research, including human trials, would be needed before any conclusions could be drawn about therapeutic benefits.
Abstract (excerpt)
Combination therapy of intracisternal (ic) infusion of magnesium sulfate solution and intravenous (iv) injection of hydrogen-enriched fluid can provide protection against delayed ischemic neurological deficits after subarachnoid hemorrhage (SAH). However, the effects of this therapy…