Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing
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DOI:
10.1016/j.bioactmat.2023.01.001
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Abstract:
Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated with consistent pro-inflammatory M1 polarization, decreased angiogenesis and increased reactive oxygen species (ROS) in the microenvironment. Herein, a poly (lactic-co-glycolic acid) (PLGA)-based microneedle patch loaded with magnesium hydride (MgH2) (MN-MgH2) is manufactured for defeating diabetic wounds. The application of microneedle patch contributes to the transdermal delivery and the prolonged release of MgH2 that can generate hydrogen (H2) and magnesium ions (Mg2+) after reaction with body fluids. The released H2 reduces the production of ROS, transforming the pathological microenvironment induced by diabetes mellitus. Meanwhile, the released Mg2+ promotes the polarization of pro-healing M2 macrophages. Consequently, cell proliferation and migration are improved, and angiogenesis and tissue regeneration are enhanced. Such intelligent microneedle patch provides a novel way for accelerating wound healing through steadily preserving and releasing of H2 and Mg2+ locally and sustainably.| Publish Year | 2023 |
|---|---|
| Country | China |
| Rank | Positive |
| Journal | Bioactive Materials |
| Primary Topic | Skin |
| Secondary Topic | Wound Healing |
| Model | Cell Culture |
| Tertiary Topic | Diabetes |
| Vehicle | Gas (Sustained Release) |
| pH | N/A |
| Application | Implantation |
| Comparison | |
| Complement |