In vivo quantification of hydrogen gas concentration in bone marrow surrounding magnesium fracture fixation hardware using an electrochemical hydrogen gas sensor

Andrew Brown, Charles Sfeir, Daoli Zhao, Sayuri Yoshizawa, Tingting Wang, William R. Heineman

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DOI: 10.1016/j.actbio.2018.04.032 DOI is the universal ID for this study.

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Statement of significance: An electrochemical H2 sensor was used to monitor the degradation of a Mg fracture fixation system in a lapine ulna fracture model. Interestingly, the H2 concentration in the bone marrow is 82% higher than H2 saturated water solution. This suggests H2 generated in situ is trapped in the bone marrow and bone is less permeable than the surrounding tissues. The detectable H2 at the rabbit skin also demonstrates a H2 sensor's ability to monitor the degradation process under thin layers of tissue. H2 sensing shows promise as a tool for monitoring the degradation of Mg alloy in vivo and creating in vitro test beds to more mechanistically evaluate the effects of varying H2 concentrations on cell types relevant to osteogenesis.

Publish Year 2018
Country United States
Rank Positive
Journal Acta Biomaterialia
Primary Topic Bone
Secondary TopicSurgery/Transplantation
Model Rabbit
Tertiary TopicNovel Therapy
Vehicle Gas (Sustained Release)
pH N/A
Application Implantation