Hydrogen Water Protects Gut Barrier During Blood Flow Injury in Rats
Hydrogen-rich saline protects intestinal epithelial tight junction barrier in rats with intestinal ischemia–reperfusion injury by inhibiting endoplasmic reticulum stress-induced apoptosis pathway
Research hubs: Digestive System
- Evidence type
- Animal study (rat)
- Authors
- Shuai Jiang, Qizhong Fan, Ming Xu, Fengchun Cheng, Zhihui Li, Guojian Ding, Lei Geng, Tingliang Fu
- Journal
- Journal of Pediatric Surgery
- Year
- 2020
- DOI
- 10.1016/j.jpedsurg.2020.01.061
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
- Health Condition
- Intestinal Ischemia-Reperfusion Injury
- Body System
- Digestive
This research was done in animals. Results in animals often don't carry over to people.
TL;DR
Hydrogen-rich saline (HRS) may protect the guts of rats from damage caused by a temporary loss of blood flow followed by its restoration.
Key Finding
Hydrogen-rich saline protected the intestinal barrier in rats with ischemia-reperfusion injury by reducing cellular stress and preventing cell death, while preserving key barrier proteins.
Summary
Researchers gave rats hydrogen-rich saline (a salt solution containing dissolved hydrogen) after they experienced intestinal ischemia-reperfusion injury—a condition where blood flow to the intestines is blocked and then restored, causing damage. The treatment protected the intestinal barrier (the lining that controls what enters the bloodstream) by reducing stress signals inside cells and preventing cell death, compared to untreated rats.
Practical Takeaway
This rat study suggests hydrogen-rich saline may help protect intestinal tissue during ischemic events, but human evidence is needed before any health claims can be made. The findings are preliminary and limited to animal models, so their relevance to human health remains unknown.
Abstract (excerpt)
Aim To investigate the effects of hydrogen-rich saline (HRS) on intestinal epithelial tight junction (TJ) barrier in rats with intestinal ischemia–reperfusion injury (IIRI). Materials and methods Thirty-two healthy male Sprague–Dawley (SD) rats were randomly divided into four groups (n = 8 each)…