Hydrogen Gas Protects Gut Stem Cells During Intestinal Blood Loss
Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (rat)
- Authors
- Ryo Yamamoto, Sayuri Suzuki, Koichiro Homma, Shintaro Yamaguchi, Tomohisa Sujino, Junichi Sasaki
- Journal
- World Journal of Gastrointestinal Surgery
- Year
- 2022
- PMID
- 36632117
- Study Type
- Rat
- Participants
- 3
- Delivery
- Gas
- Dose
- continuous 3% hydrogen gas inhalation during 60-min mesenteric artery occlusion and 60-min reperfusion
- H₂ concentration
- 3% H2 gas
- Outcome
- Positive
- Peer Reviewed
- Yes
- Cited by
- 4 (OpenAlex, as of November 2026)
- Country
- Japan
TL;DR
Inhaling hydrogen gas helps protect the gut's repair cells and reduces cell damage from reduced blood flow and subsequent restoration in rats.
Key Finding
Hydrogen gas inhalation reduced intestinal stem cell death and oxidative stress (cellular damage from harmful molecules) during simulated mesenteric ischemia-reperfusion injury in rats, with the protective effect concentrated where stem cells reside.
Summary
Researchers studied whether hydrogen gas could protect the intestines during a serious condition called mesenteric ischemia (when blood flow to the intestines is blocked). Using rats, they blocked blood flow to the intestines for an hour, then restored it while giving some rats hydrogen gas to breathe. They found that hydrogen gas reduced cell death in the intestinal lining, particularly in stem cells (special cells that help repair the intestines), and decreased harmful molecules called reactive oxygen species that damage tissue.
Practical Takeaway
This rat study suggests hydrogen gas may help protect intestinal stem cells during serious blood flow problems, which could potentially improve recovery after emergency intestinal surgery. However, this is early animal research—human studies are needed to determine if these benefits apply to patients and what dose or delivery method would be safe and effective.
Abstract (excerpt)
Background: Patients with mesenteric ischemia frequently suffer from bowel necrosis even after revascularization. Hydrogen gas has showed promising effects for ischemia-reperfusion injury by reducing reactive oxygen species in various animal and clinical studies. We examined intestinal tissue…