Hydrogen-rich saline protects against ultraviolet B radiation injury in rats

Bingrong Zhou, Dan Luo, Wei Li, Xuejun Sun, Ze Guo

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DOI: 10.7555/JBR.26.20110037 DOI is the universal ID for this study.

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Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage. Ultraviolet B (UVB) is the major component of UV radiation which induces the production of reactive oxygen species (ROS) and plays an important role in photo-damage. Hydrogen gas reduces ROS and alleviates inflammation. In this study, we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused by UVB radiation. UVB radiation was irradiated on female C57BL/6 rats to induce skin injury. Hydrogen-rich saline and nitrogen-rich saline were administered to rats by intraperitoneal injection. Skin damage was detected by microscope after injury. UVB radiation had a significant affection in tumor necrosis factor alpha, interleukin (IL)-1β and IL-6 levels, tissue superoxide dismutase, malondialdehyde and nitric oxide activity. Hydrogen-rich saline had a protective effect by altering the levels of these markers and relieved morphological skin injury. Hydrogen-rich saline protected against UVB radiation injury, possibly by reducing inflammation and oxidative stress.

Publish Year 2012
Country China
Rank Positive
Journal Journal of Biomedical Research
Primary Topic Skin
Secondary TopicRadioprotection
Model Rat
Tertiary TopicUV Radiation
Vehicle Saline (Dissolved)
pH Neutral
Application Injection