Hydrogen Water Reduces Gum Disease Inflammation in Rats
- Authors
- Rini Devijanti Ridwan, Wisnu Setyari Juliastuti, R. Darmawan Setijanto
- Journal
- Dental Journal (Majalah Kedokteran Gigi)
- Year
- 2017
- DOI
- 10.20473/j.djmkg.v50.i1.p10-13
- Study Type
- Rat
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- Indonesia
- Health Condition
- Chronic Periodontitis
- Body System
- Oral Health
TL;DR
Drinking alkaline water with magnesium ions can reduce cell damage in rats with gum disease.
Key Finding
Rats with gum disease that consumed electrolyzed reduced water had significantly lower blood levels of malondialdehyde, a marker of oxidative stress, compared to rats drinking regular water.
Summary
Researchers gave rats with gum disease either regular drinking water or electrolyzed reduced water (ERW), which is alkaline water made through electrolysis that contains magnesium ions. They measured malondialdehyde (MDA), a marker of oxidative stress or cellular damage, in the rats' blood. Rats that drank ERW had significantly lower MDA levels than those drinking regular water, suggesting ERW may help reduce the cellular damage associated with gum disease.
Practical Takeaway
This early animal study suggests ERW may help reduce oxidative stress markers associated with gum disease, but the findings are limited to rats and the study duration and sample details were not reported. Much more research, including human trials, would be needed before drawing conclusions about whether ERW could benefit people with periodontal disease.
Abstract
Background: Periodontal disease is a progressive destructive change that causes loss of bone and periodontal ligaments around the teeth that can eventually lead to its loss. The main bacteria in chronic periodontitis is Porphyromonas gingivalis. Aggregatibacter actinomycetemcomitans, a pathogen associated with aggressive periodontitis, initiates a proinflammatory response that causes tissue destruction of periodontal, alveolar bone resorption and subsequent tooth loss. Electrolyzed reduced water (ERW) is an alkaline water, ERW not only has a high pH and low oxidation reduction potential (ORP), but also contains several magnesium ions. Magnesium ions proven effective for the prevention of various diseases. Purpose: To analyze the level of malondialdehyde (MDA) in Wistar rats with cases of chronic and aggressive periodontitis that consumed ERW. Method: Wistar rats were divided into four groups, each group with 10 rats. The first and second group were Wistar rat with chronic periodontitis and consume drinking water and ERW. The third and fourth group were Wistar rat with aggressive periodontitis and consume drinking water and ERW. This experiment is done by calculating the levels of MDA. The calculation of the levels of MDA is done with spectrophotometric assay for MDA. Result: The results of this experiment show that the level of MDA in serum in group that consume ERW had decreased significantly different with thegroup that consume drinking water with the statistical test. Conclusion: It can be concluded that ERW can decrease the MDA level in Wistar rat with chronic and aggressive periodontitis case.