Hydrogen Nanobubble Water Shows Antioxidant Activity in Lab Tests
Antioxidant Activity of Hydrogen Nanobubbles in Water with Different Reactive Oxygen Species both in Vivo and in Vitro
Research hubs: Oxidative Stress
This research was done on cells or tissue in a lab, not in people or animals.
- Evidence type
- Laboratory study (cells or tissue)
- Authors
- Shu Liu, Seiichi Oshita, Dang Quoc Thuyet, Masanao Saito, Takahiko Yoshimoto
- Journal
- Langmuir
- Year
- 2018
- PMID
- 30189133
- Study Type
- Molecular Assay
- Delivery
- Water, Commercial (Melodian)
- Outcome
- Neutral
- Peer Reviewed
- Yes
- Cited by
- 35 (OpenAlex, as of November 2026)
- Country
- Japan
TL;DR
Hydrogen-infused nanobubble water shows promise as a powerful antioxidant against certain harmful oxygen compounds, but it may also hinder the growth of barley seeds.
Key Finding
Hydrogen nanobubble water neutralized harmful reactive oxygen species more effectively than regular hydrogen water, but it also inhibited normal seed germination, indicating that its effects vary depending on cell type and biological context.
Summary
Researchers tested hydrogen nanobubbles (tiny hydrogen gas bubbles) dissolved in water to see how well they could neutralize harmful molecules called reactive oxygen species (ROS). They tested this both in laboratory conditions and in living barley seeds. Hydrogen nanobubble water was better at removing certain harmful ROS than regular hydrogen water, but it also slowed down normal seed germination, suggesting that its effects depend on the specific cell type and situation.
Practical Takeaway
This laboratory and plant-based study suggests hydrogen nanobubbles may have stronger antioxidant properties than regular hydrogen water, but the finding that it slowed normal seed growth raises questions about whether it could interfere with healthy cellular processes in humans. Much more research, including human studies, would be needed before drawing conclusions about health benefits. The study's use of barley seeds rather than human cells limits what we can infer about real-world applications.
Abstract (excerpt)
Hydrogen water as a new therapeutic antioxidant has been widely used in living organisms under stress. In this study, we applied nanobubble (NB) technology to hydrogen water. The antioxidant capacity of hydrogen NB water was studied with respect to different reactive oxygen species (ROS) both…