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Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury
(1) Background: Chronic inflammation is considered an important pathological basis underlying the development and progression of multiple metabolic liver diseases; although hydrogen-rich water (HRW) has shown beneficial effects in acute inflammation, its long-term impact on chronic hepatic…
Hydrogen‐Mediated Activation of the Nrf2/ <scp>HO</scp> ‐1 Signaling Pathway Improves Cognitive Impairment in Sleep‐Deprived Mice
ABSTRACT Aims This study investigated the effects of hydrogen (H 2 ) on cognitive impairment in sleep‐deprived mice mediated by the nuclear factor erythroid 2‐related factor 2 (Nrf2)/heme oxygenase‐1 (HO‐1) signaling pathway. Methods A chronic sleep deprivation (SD) model was established using…
Hydrogen-Rich Water as a Performance-Enhancing Aid in National-Level Finswimmers: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
Purpose : We investigated whether a 4-day intake of hydrogen-rich water (HRW) improves finswimming performance and alters physiological and perceptual markers including blood lactate, rating of perceived exertion, and oxidative stress. Methods : Eight females and 4 males, age 21 (5) and 19 (1)…
Hydrogen-rich water has a positive effect on heart rate variability at rest and during orthostatic loading, but not during cycling, in healthy adults: A pilot randomized, placebo-controlled crossover trial
Hydrogen-rich water has various health benefits, such as substantially reducing lactate accumulation during high-intensity exercise. However, little is known about the effects of hydrogen-rich water on physiological responses during physical activity compared to those at rest. Therefore, we…
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage
Background: Intracerebral hemorrhage (ICH) is a devastating stroke subtype with high mortality and disability, primarily driven by secondary brain injury involving oxidative stress, neuroinflammation, and apoptosis. Molecular hydrogen (H₂) exhibits potent neuroprotective effects; however…
Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats
Myocardial ischemia/reperfusion (MIR) injury remains a major clinical challenge with limited therapeutic options. Although molecular hydrogen (H₂) possesses therapeutic potential, its clinical translation is hindered by poor solubility and the lack of targeted delivery and real-time monitoring…
Inflamed vessel–anchored release of H <sub>2</sub> across the blood-brain barrier for ischemic stroke neuroprotection
Ischemic stroke followed by reperfusion urgently requires safe and efficient cytoprotective strategies, a need still unmet by current pharmacotherapies. Nanotechnology holds promise for improved drug delivery to the brain, yet the efficacy of nanomaterials crossing the blood-brain barrier (BBB)…
Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy
Autophagy is an intracellular recycling system that contributes to the maintenance of cellular homeostasis. However, by providing tolerance to various stressors, autophagy promotes the survival and proliferation of cancer cells and confers resistance to chemotherapy. Anticancer drugs activate…
Post-Ingestion Blood Hydrogen Kinetics Following Oral Hydrogen-Rich Water Intake in Healthy Adults: A Pilot Pharmacokinetic Study
Introduction: Molecular hydrogen (H2) has gained attention as a therapeutic agent due to its antioxidant and anti-inflammatory properties. However, human Pharmacokinetic (PK) data remain limited, particularly for Hydrogen-Rich Water (HRW). This study aimed to characterize blood hydrogen kinetics…
Hydrogen-rich jelly exhibits a positive effect on heart rate variability during orthostatic loading in healthy adults: a randomized crossover trial
Hydrogen gas may improve autonomic regulation. The effects of hydrogen-rich jelly (HRJ) on autonomic responses during postural transition have not yet been investigated. This double-blind, randomized, placebo-controlled crossover trial evaluated HRJ effects on heart rate variability (HRV) in 50…
Hydrogen-rich water attenuates radiation-induced oral mucositis in mice via antioxidant and gut microbiota-stabilizing effects: a longitudinal study
Radiation-induced oral mucositis (RIOM) frequently complicates head and neck radiotherapy, leading to severe pain, compromised nutrition, and often requiring treatment modifications. Although craniofacial-only irradiation is confined to the head and neck region, it can still disrupt gut…
Core-Shell Microspheres Enabling Sustained Hydrogen Release and Peroxidase-Like Catalytic Activity for Periodontitis Therapy
ABSTRACT Periodontitis is among the most prevalent and challenging oral diseases worldwide. Effective intervention requires strategies that not only eliminate pathogens but also modulate the dysregulated oxidative microenvironment. Hydrogen (H 2 ) therapy holds promise in periodontitis…
Potential subtype-specific alterations in gut microbiota and branched-chain amino acid metabolism in hydrogen- and methane-predominant small intestinal bacterial overgrowth
We aimed to investigate the clinical, microbiome, and metabolomic characteristics of hydrogen (H₂)- and methane (CH₄)-predominant small intestinal bacterial overgrowth (SIBO) subtypes. We retrospectively enrolled adults who underwent standardized lactulose hydrogen–methane breath testing between…
The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome
Background. Medical gases, inhaled nitric oxide (iNO) and molecular hydrogen (iH2), have been used in the therapy for various medical conditions. When combined, these gases have shown to be more effective and safer for patients, and may become a promising treatment option for various diseases…
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice
Molecular hydrogen (H2) exhibits anti-inflammatory and antioxidant properties. However, its role in ultraviolet B (UVB)-induced skin carcinogenesis remains unclear. Male HR-1 hairless mice received continuous H2 (2% hydrogen gas inhalation plus hydrogen-rich water (HRW)) or control treatment…
Comparison of hydrogen administration methods in the treatment of radiation-induced heart disease in rats
Ionizing radiation is a known risk factor for the occurrence and development of cardiovascular diseases, particularly in patients receiving thoracic radiotherapy. This exposure leads to oxidative stress and inflammation, which can damage cardiac tissue and vascular endothelium. Molecular hydrogen…
Beyond Supportive Care: Mitochondria as a Strategic Therapeutic Avenue in Acute Pancreatitis
Purpose: To synthesize experimental and clinical evidence on mitochondria-targeted strategies in acute pancreatitis (AP) and evaluate the potential of interventions that preserve or restore mitochondrial function to reduce pancreatic injury and systemic complications. Methods: We conducted…
An Epidemiological Study on the Relationship between Gastric Mucosal Atrophy, Exhaled Hydrogen Concentration, and Gut Microbiota
Introduction: This study aimed to conduct an epidemiological investigation of the relationship between gastric mucosal atrophy and exhaled hydrogen gas concentration, including gut microbiota, in residents who participated in health checkups. Methods: Based on pepsinogen I <70 ng/mL and PG I/PG II…
Hydrogen reshapes the senescent microenvironment of callus to enhance the healing of anti-osteoporotic-drug-induced atypical femoral fracture
Long-term bisphosphonates (BPs) are widely used to treat osteoporosis, however, they are paradoxically associated with the development of atypical femoral fractures (AFFs), which often characterized by impaired healing. In this study, we induced an AFF model using zoledronate (ZOL) administration…
Interstitial Cystitis and Dietary Interventions: A Systematic Review
Introduction and hypothesis: Interstitial cystitis/bladder pain syndrome (IC/BPS) is prevalent and disrupts daily life. Dietary modification is commonly recommended, but evidence is fragmented. We systematically compared dietary interventions; we hypothesized that individualized elimination may…