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DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis
ABSTRACT Objectives: Therapeutic effects of hydrogen (H 2 ) on sepsis‐associated encephalopathy (SAE), a severe neuroinflammatory disease, have been reported, but the underlying mechanism remains unclear. Metabolomic and phosphoproteomic analyses were utilized to explore the therapeutic mechanism…
Hydrogen alleviates right ventricular hypertrophy by inhibiting ferroptosis <i>via</i> restoration of the Nrf2/HO-1 signaling pathway
BACKGROUND Right ventricular hypertrophy (RVH) occurs because of volume or pressure overload within the right ventricular (RV) system. RVH is associated with complex pathological changes, including myocardial cell injury, apoptosis, myocardial fibrosis, neuroendocrine disturbances, and abnormal…
Urinary and oral microbiota in Polish women: a pilot case-control study of breast cancer
IntroductionThe human microbiota can be a critical component in the development and progression of various diseases, including cancer. This study aims to investigate the composition of the urinary and oral microbiota in Polish breast cancer (BC) patients relative to healthy controls (HCs)…
Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation
Background/aim: Rheumatoid arthritis (RA) is a chronic autoimmune disease with systemic manifestations. Methotrexate (MTX) remains a cornerstone of RA treatment, offering significant therapeutic benefits; however, it is also associated with adverse effects, particularly myelosuppression. Molecular…
Sustained-Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy
Effective management of postoperative pain and wound healing presents significant challenges in clinical settings, driving the need for innovative therapeutic approaches. The analgesic and wound healing effects of hydrogen (H2) have gradually been recognized; however, the lack of efficient hydrogen…
Six Hours of Hydrogen Gas Inhalation Has a Neuroprotective Effect Even in Piglets with Delayed Functional Recovery
Introduction: Combined therapeutic hypothermia (TH) and 24-h hydrogen (H2) gas inhalation reduces seizure burden in piglets in the latent phase of hypoxic-ischemic (HI) injury versus TH alone. Nevertheless, the effects of H2 gas in the earliest phase following resuscitation were unclear. Methods…
Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells
Background: Diabetic wounds are major clinical challenges, often complicated by oxidative stress and free radical generation. Hydrogen (H2), a selective antioxidant, offers potential as a therapeutic agent for chronic diabetic wounds. However, its precise mechanisms remain underexplored. Objective…
Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition
Introduction: Hydrogen gas has demonstrated significant antioxidant and anti-inflammatory properties, suggesting potential therapeutic benefits in TBI. Methods: We subjected to controlled cortical impact in mice to construct TBI model. They received an intraperitoneal injection of MCC950…
Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization
Background/aim: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by bile duct destruction, cholestasis, and inflammation, often leading to fibrosis and cirrhosis. While ursodeoxycholic acid (UDCA) is the standard treatment, some patients exhibit suboptimal…
Hydrogen-Positive Small Intestinal Bacterial Overgrowth (SIBO) in Japanese Patients With Chronic Intestinal Pseudo-Obstruction (CIPO): A Cross-Sectional Study
Background: Evidence for small intestinal bacterial overgrowth (SIBO) in chronic intestinal pseudo‑obstruction (CIPO) remains limited in Asian populations and by gas phenotype. This study aimed to determine the prevalence and gas phenotype distribution (hydrogen-positive SIBO vs. intestinal…
A Stable and Local H<sub>2</sub> Nanogenerator for Antifading Responses
Persistent inflammation effects existed in the senescence microenvironment, and hydrogen (H2) was an antioxidant stress agent and could solve the aging and inflammation. In view of the issue of low solubility of H2 and conversion efficiency of traditional hydrogen therapy, an in-site hydrogen…
Hydrogen-Rich Water Decreases Muscle Damage and Improves Power Endurance in Elite Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial
Background: Physical activity significantly increases the production of reactive oxygen species in the body. Molecular hydrogen has been shown to have safe and effective antioxidant properties on athletes. However, research on elite athletes is scarce. Methods: A randomized, double-blinded…
The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial
The primary objective of this pilot study was to assess the impact of consuming hydrogen-rich water (HRW) for a duration of six weeks on exercise-related biomarkers in previously untrained men and women aged over 50 years, subsequent to a resistance training program. Twenty-seven apparently healthy…
Effects Of 12-Week Hydrogen-Rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults with Metabolic Syndrome Stratified by Breath Hydrogen Levels: A Randomized Controlled Trial
Metabolic syndrome is a cluster of risk factors that increases the likelihood of cardiovascular disease and type 2 diabetes. Hydrogen-rich water (HRW) has been proposed as a nutritional strategy to improve metabolic health, although individual differences in endogenous hydrogen production may…
Hydrogen inhalation and intrathecal magnesium sulfate ameliorate ischemia by suppressing cortical spreading depolarization in a rat subarachnoid hemorrhage model
This study investigated whether inhaled hydrogen and intrathecal magnesium could mitigate cortical spreading depolarization and delayed cerebral ischemia in a rat model of subarachnoid hemorrhage. Adult male rats underwent subarachnoid hemorrhage induction with nitric oxide synthase inhibition…
Hydrogen Incorporation Selectively Modulates the Catalytic Performance of Pd Nanozymes for Cascade-Catalytic Tumor Therapy
Pd-based nanozymes have emerged as promising alternatives to natural enzymes, but their application is still constrained due to suboptimal activity and poor specificity. As efficient hydrogen storage nanomaterials, the specific implications of implanted hydrogen on the enzyme-mimicking activity…
Hydrogen enhanced photothermal therapy for redox-regulated tumor apoptosis and immune reprogramming
Photothermal-catalysis enables controlled hydrogen release and redox modulation, with applications in biomedical therapy. Despite growing interest in hydrogen therapy, its effects on immune cells within the tumor microenvironment (TME) remain insufficiently elucidated, specifically regarding…
Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress
Pemphigus-associated interstitial lung disease (P-ILD) is a severe complication observed in pemphigus patients that is characterized by pulmonary interstitial inflammation and fibrosis. This study investigated the role of anti-desmoglein (Dsg) 1/3 antibodies in P-ILD pathogenesis and evaluated…
The Improvement of Physical Function and Caregiver Burden by a Multimodal Intervention: A Case Study of Combined Exercise Therapy, Nutritional Guidance, and Hydrogen Gas Inhalation Therapy
The objective of this exploratory case study was to examine the impact of a multifaceted intervention, which incorporated exercise therapy, nutritional guidance, and hydrogen gas inhalation, on the physical function and caregiver burden of an older female patient suspected of having sarcopenia…
Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing
Objective Burns refers to a severe form of trauma that often leads to localized and systemic inflammatory responses, oxidative stress, and immune dysfunction. Patients with severe burns are highly susceptible to the development of postburn sepsis, a condition influenced by multiple factors, such…