Hydrogen Water and Lung Disease in Pemphigus Model in Mice
Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress
Research hubs: Respiratory System
This research was done in animals. Results in animals often don't carry over to people.
- Evidence type
- Animal study (mouse)
- Authors
- Chang Tang, Lanting Wang, Zihua Chen, Xiangguang Shi, Yahui Chen, Jin Yang, Haiqing Gao, Chenggong Guan, Shan He, Luyao Zhang, Shenyuan Zheng, Fanping Yang, Sheng-An Chen, Li Ma, Zhen Zhang, Ying Zhao, Qingmei Liu, Jiucun Wang, Xiaoqun Luo
- Journal
- International Journal of Molecular Sciences
- Year
- 2025
- PMID
- 40362440
- Study Type
- Mouse
- Delivery
- Water (Electrolysis)
- Dose
- hydrogen-rich water
- Outcome
- Positive
- Peer Reviewed
- Yes
- Country
- China
TL;DR
Breathing in hydrogen-rich water may help treat a serious lung condition linked to pemphigus, an autoimmune skin disease, by reducing inflammation and preventing scarring in the lungs.
Key Finding
In mice with pemphigus-associated lung disease, hydrogen-rich water significantly reduced oxidative stress, decreased lung inflammation, and prevented pulmonary fibrosis (lung scarring).
Summary
This study used mice to investigate how pemphigus-associated interstitial lung disease (a serious lung condition that can occur in pemphigus patients) develops and whether hydrogen water might help treat it. Researchers found that certain antibodies triggered lung inflammation and scarring in mice, and that hydrogen water reduced oxidative stress (cellular damage from unstable molecules), decreased inflammation, and prevented lung scarring.
Practical Takeaway
This is early, mouse-only research suggesting hydrogen water may have protective effects against a specific type of lung disease. However, these results cannot yet be applied to humans—much more research, including human clinical trials, would be needed before hydrogen water could be considered a treatment for this condition.
Abstract (excerpt)
Pemphigus-associated interstitial lung disease (P-ILD) is a severe complication observed in pemphigus patients that is characterized by pulmonary interstitial inflammation and fibrosis. This study investigated the role of anti-desmoglein (Dsg) 1/3 antibodies in P-ILD pathogenesis and evaluated…