All Studies
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Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
Background: Hydrogen therapy, which involves the intake of hydrogen as an antioxidant, has been reported to be effective against various oxidative stress-related diseases. However, current methods of hydrogen administration present various problems. Therefore, new methods that allow for the safe…
The impact of perioperative hydrogen gas inhalation on postoperative recovery in day surgery patients: a research study
Hydrogen has been demonstrated to exert anti-inflammatory effects in various clinical settings. This prospective, double-blind, randomized controlled trial was conducted at a day surgery center to evaluate whether perioperative hydrogen inhalation improves recovery outcomes in patients undergoing…
Nano-Metal Hydrogen Therapy Targeting Immune Cells Drives Synergistic Anti-Tumor Effects
Hydrogen is employed as a therapeutic gas in the treatment of stroke, tissue repair, and cancer, owing to its excellent biocompatibility, antioxidant properties, anti-inflammatory effects, and regulation of cellular metabolism. Moreover, nanometallic materials generate hydrogen through…
Molecular hydrogen in cancer therapy: Bioactive materials for tumor-targeted delivery and in situ generation
Molecular hydrogen (H2) therapy has emerged as a promising adjunctive strategy in oncology, primarily attributed to its selective antioxidant, anti-inflammatory, and cytoprotective properties. Advances have been driven by the integration of mechanistic studies on H2-mediated redox regulation…
Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial
Background: Acute high-intensity exercise induces transient inflammatory and oxidative stress responses, mediated by redox-sensitive signaling pathways and reflected by elevations in interleukin-6 (IL-6) and lipid peroxidation products. Modulation of these responses through hydration-based redox…
Therapeutic potential of hydrogen-rich water (HRW) in oxidative stress-related diseases
Oxidative stress is a central mechanism in metabolic, cardiovascular, and neurodegenerative diseases, contributing to inflammation, mitochondrial dysfunction, and apoptosis. Consequently, redox-modulating therapies are increasingly explored as potential therapeutic strategies. This review evaluates…
Dual-Functional Microreactor Enabling Hydrogen Therapy and Mild Photothermal Therapy for Osteoarthritis Treatment
Osteoarthritis (OA) is a prevalent degenerative joint disorder. Current therapeutic approaches have yielded suboptimal clinical outcomes, primarily due to their inability to effectively eliminate reactive oxygen species (ROS), which are the key drivers of inflammatory pathology. Molecular hydrogen…
High-concentration hydrogen mitigates cognitive impairment in a murine model of Sepsis-associated encephalopathy by enhancing oligodendrocyte maturation and myelination in the mPFC
Sepsis-associated encephalopathy (SAE) commonly elicits long-lasting cognitive deterioration. Although hydrogen inhalation exerts protective effects in sepsis, its underlying mechanisms remain unclear. Dysregulated oligodendrocyte maturation and myelin architectural defects are pivotal pathological…
Hydrogen alleviates sepsis-associated encephalopathy via ATG9B-dependent mitophagy
Background: Sepsis-associated encephalopathy (SAE) is a severe complication with high mortality and limited therapeutic options. Molecular hydrogen (H₂) has shown neuroprotective potential, but its mechanism remains elusive. Methods: SAE was induced in C57BL/6J mice by cecal ligation and puncture…
Post-Ingestion Blood Hydrogen Kinetics Following Oral Hydrogen-Rich Water Intake in Healthy Adults: A Pilot Pharmacokinetic Study
Introduction: Molecular hydrogen (H2) has gained attention as a therapeutic agent due to its antioxidant and anti-inflammatory properties. However, human Pharmacokinetic (PK) data remain limited, particularly for Hydrogen-Rich Water (HRW). This study aimed to characterize blood hydrogen kinetics…
Generation and Application of Ultra-Fine, Long-Term Stable Nanobubble Water: An Evaluation of Inclusion Effects on Aromatic Components and Antimicrobial Activity
Nano- and pico-bubble water (NPB), containing hydrogen or ozone, is widely used as a cleaning agent due to its bactericidal and antiviral properties. However, some products-such as certain hydrogen waters-contain only large bubbles or have an extremely low bubble count, making them sometimes…
Hydrogen-Rich Saline Accelerates Diabetic Wound Healing in Vivo and Its Interaction with the Renin-Angiotensin System Pathway
Aim: Oxidative stress and chronic inflammation represent two major contributors to slowing the process of diabetic wound healing. So far, there is a lack of characterization of the mechanistic role of hydrogen-rich saline (HRS), despite its antioxidant potential, in diabetic wound repair. This…
Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice
Molecular hydrogen has been reported to exert antioxidant and anti-inflammatory effects; however, its impact on inflammation and gut microbiota under aging-associated metabolic stress remains unclear. In this study, we investigated the effects of hydrogen-rich jelly (HRJ) in senescence-accelerated…
Mechanism of hydrogen-rich water alleviating radiation-induced cognitive impairment through PI3K/AKT/Caspase-9 pathway mediating anti-oxidation
Explore the mechanism by which the antioxidant effect of hydrogen-rich water alleviates radiation-induced cognitive impairment based on the PI3K/AKT/Caspase-9 signaling pathway. Male SD rats were randomly divided into control group (Control group), simple irradiation (IR) group, high-dose…
Hydrogen-Rich Water Attenuates Diarrhea in Weaned Piglets via Oxidative Stress Alleviation
Early weaning of piglets elicits weaning stress, which in turn induces oxidative stress and consequently impairs growth and development. Hydrogen-rich water (HRW), characterized by selective antioxidant properties, mitigates oxidative stress damage and serves as an ideal intervention. This study…
A H2-bioreactor for mitochondrial rehabilitation in infected bone defects regeneration
The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs generates to a vicious oxidation-inflammation cycle that impairs bone…
Nanobiocatalyst-Driven Spatiotemporal Hydrogen Delivery Induces Dormancy Potentiated Catalytic Tumor Therapy
Colorectal cancer remains a therapeutic challenge due to systemic toxicity and the suboptimal efficacy of conventional therapies. Emerging evidence indicates that molecular hydrogen (H2) exerts antitumor effects through proliferation suppression and induction of a "tumor dormancy" phenotype…
Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice
Objectives: As a known antioxidant, hydrogen has been useful for treating pressure ulcers. However, conventional methods of hydrogen administration have limitations with regard to dosage and continuity of hydrogen intake. This study evaluated the efficacy of a novel Si-containing agent that can…
Research on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms
Ovarian cancer is one of the most fatal malignancies in women worldwide; current treatment approaches still struggle to effectively control tumor progression. Therefore, it is imperative to explore novel and more effective therapeutic approaches. Hydrogen shows promise as a novel adjuvant therapy…
In vitro hydrogen production by mammal [FeFe]-hydrogenase-like protein
Although emerging evidence in mammals reveals that exogenously applied H2 positively regulates numerous physiological and pathological responses, it remains unclear whether and how mammalian cells produce H2 endogenously. Here, we report for the first time that recombinant human (Homo sapiens)…