Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H2) is known to have anti‐inflammatory effects; however, the bioavailability of directly administered H2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H2 at inflamed tissues is proposed. The delivery system comprises ...

Hydrogen water as a new therapeutic antioxidant has been widely used in living organisms under stress. In this study, we applied nanobubble (NB) technology to hydrogen water. The antioxidant capacity of hydrogen NB water was studied with respect to different reactive oxygen species (ROS) both in vitro and in vivo. Using a relatively weak reduced dye, APF, we showed that hydrogen NB water can ...

The main cause of arteriosclerosis is atherosclerosis in the aorta. Atherosclerosis is recognized as a chronic inflammatory condition that begins with the dysfunction or activation of arterial endothelium. Low-density lipoprotein (LDL) and especially its oxidized form play a key role in endothelial dysfunction and atherogenesis. Recent studies showed that senescent cells are involved in the ...

Background: Cathode side commercial hydrogen dissolved water (HW) exhibits low dissolved oxygen, high dissolved hydrogen and significant negative redox potential. Therapeutic applications of HW have recently been reported. Thus, the present study aimed to examine effects of HW consumption on renal injury in a rat model of chronic kidney disease.Methods: Twenty Dahl S rats were given HW and tap ...

Background: Asthma is an abnormality in the form of chronic airway inflammation which can be reduced by providing asthma-induced gymnastics and healthy lifestyle such as consuming alkaline water.Aims: The objective of this study is to examine a combination of alkaline water provision and asthma-induced gymnastics towards peak expiratory flow rate of asthma patients at Surakarta Lung Clinic, ...

Recently, molecular hydrogen (H 2 )has become known as a new class of antioxidants and redox-modulating interventions. Effects of H 2 have been documented for many acute and chronic pathological conditions. The present study was aimed at determining the effect of hydrogen on the physiology and longevity of Drosophila. The flies were given a patented food supplement consisting of a mixture of inert ...

We investigated whether non-digestible saccharide fermentation-derived hydrogen molecules (H 2 ) in rat colon could improve the in vivo reduction–oxidation balance via regeneration of α-tocopherol, by assessing their effect on hydroxyl radicals, the α-tocopherol concentration and the reduction–oxidation balance. In experiment 1, a Fenton reaction with phenylalanine (0 or 1.37 mmol/L of H 2 ) ...

Objective: Electrolyzed oxidizing/reducing water is popular as health beneficial water in Indonesia. In this study, we examined the level of antibacterial,anticancer, and antioxidant activity of the electrolyzed water.Methods: The efficacy of electrolyzed water produced by Enagic® at six level pH (2.5, 6.0, 7.0, 8.5, 9.0, and 9.5) was investigated. Antibacterialactivity was evaluated using a ...

In this study, we use a Drosophila model to examine the effect of drinking hydrogen water on survival rate after fasting. The cells produce free radicals to help to absorb nutritious substances due to metabolism, which is a unique phenomenon for biological organisms. But if over the tension of free radicals can seriously affect the physiological functions, and even lead to death. Recently, ...

The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW ...

Objective：Traumatic brain injury (TBI) is one of the most serious public health problems in the world. Hydrogen (H2), a flammable, colorless, and odorless gas, has been observed to have preventive and therapeutic effects on brain trauma and other neurological disorders, but its exact mechanism has not been fully clarified. Methods: To further study the mechanism underlying the role of hydrogen ...

Molecular hydrogen recently attracted lots of attention in biomedical community because of its abilities to modulate signal transduction, protein phosphorylation, and gene expression that enable its anti-inflammatory, anti-allergy, and anti-apoptotic activities. However, controllable and local delivery of hydrogen molecules to tissues still remains challenging. Here, we propose a new method of ...

In this study, hydrogen generation powder samples were prepared using zinc carbonate as a precursor, at a temperature varying from 400 to 700 °C in H2 atmosphere, and were characterized in terms of antioxidant activity. The concentration of dissolved hydrogen obtained by the powder samples was measured using a dissolved hydrogen meter as a function of time. In addition, the antioxidant activity ...

Molecular hydrogen (H2) is recognized as a medical gas applicable to numerous diseases including neurodegenerative diseases, metabolic disorders, and rheumatoid arthritis. Although the efficacy of H2 is reportedly attributed to its scavenging capability against the hydroxyl radical, the mechanisms underlying its therapeutic efficacy are not fully understood. Herein, we estimated the role of H2 in ...

No abstract available