Effects of long-term hydrogen intervention on the physiological function of rats

Fang-Di Ju, Fei Xie, Jin He, Peng-Xiang Zhao, Qing-Hui Zhao, Sheng-Nan Ma, Ting-Ting Yao, Xiao-Kang Zhang, Xiao-Yan Jin, Xiao-Yang Li, Xue-Mei Ma, Yan Zhang, Yang Yi, Ying-Xian Li, Zhi-Ming Xun

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DOI: 10.1038/s41598-020-75492-w DOI is the universal ID for this study.

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The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW intake and HI remains elusive. In the present study, the body weight and 13 serum biochemical parameters were monitored during the six-month hydrogen intervention, all these parameters were significantly altered by oral intake of HRW or HI. Among the 13 parameters, the most striking alterations induced by hydrogen treatment were observed in serum myocardial enzymes spectrum. The results also showed that the changes in these parameters occurred at different time points, and the alterations in most of the parameters were much more significant in HI than HRW. The results of this study provides the basic data for the mechanism research and application of molecular hydrogen in the future.

Publish Year 2020
Country China
Rank Positive
Journal Nature Scientific Reports
Primary Topic Whole Body
Secondary TopicBlood Composition
Model Rat
Tertiary TopicOxidative Stress
Vehicle Water (Mg-Chemico)
pH Alkaline
Application Mixed