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Studies Found: 590

WHOLE BODY - ROS-SCAVENGING

Effects of Drinking a Water Product with Anti-Oxidant Activities In Vitro on the Blood Levels of ...

Year Published: 2006

The in vivo effects of drinking a water product, which had been confirmed to have antioxidant activi- ties in vitro, were preliminarily studied by monitoring the blood concentrations of oxidative stress marker substances in the two group subjects who ingested the same quantity of the water product and a tap water solution during the same time. The results indicated that hydrogen gas and reductive ...
LIVER - SURGERY/TRANSPLANTATION

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing ...

Year Published: 2007

We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a ...
INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen Inhalation Ameliorates Oxidative Stress in Transplantation Induced Intestinal Graft Injury

Year Published: 2008

Ischemia/reperfusion (I/R) injury during small intestinal transplantation (SITx) frequently causes complications including dysmotility, inflammation and organ failure. Recent evidence indicates hydrogen inhalation eliminates toxic hydroxyl radicals. Syngeneic, orthotopic SITx was performed in Lewis rats with 3 h of cold ischemic time. Both donor and recipient received perioperative air or 2% ...
WHOLE BODY - SEPSIS

Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and ...

Year Published: 2010

Despite recent advances in antibiotic therapy and intensive care, sepsis is still considered to be the most common cause of death in intensive care units. Excessive production of reactive oxygen species plays an important role in the pathogenesis of sepsis. Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-containing preservation solution relieves oxidative stress and inflammatory damage of rat ...

Year Published: 2010

Objective: To study the effect of hydrogen-containing preservation solution against oxidative stress and inflammatory damage of rat donor heart. Methods: Thirty-two SD rats were evenly randomized into four groups(n = 8) : control group (the hearts were protected by HTK solution), H1 group (hydrogen concentration was about 0.2 mmol/L in the HTK solution), H2 group (hydrogen concentration was about ...
BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced ...

Year Published: 2010

This study is to examine if hydrogen-rich saline reduced amyloid beta (Abeta) induced neural inflammation, and learning and memory deficits in a rat model. S-D male rats (n=84, 280-330g) were divided into three groups, sham-operated, Abeta1-42 injected and Abeta1-42 plus hydrogen-rich saline-treated animals. Hydrogen-rich saline (5ml/kg, i.p., daily) was injected for 14days after ...
BRAIN - TRAUMATIC BRAIN INJURY

Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative ...

Year Published: 2010

Traumatic brain injury (TBI) is a leading cause of mortality and disability among the young population. It has been shown that hydrogen gas (H(2)) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (OH, the most cytotoxic ROS). Recently, we have found that H(2) inhalation significantly improved the survival rate and organ damage of septic mice. In the present study, ...
BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappa B ...

Year Published: 2011

This study is to examine if hydrogen-rich saline reduced amyloid-beta (A beta) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-kappa B. Sprague-Dawley male rats (n = 18,280-330 g) were divided into three groups, sham operated, A beta 1-42 injected and A beta 1-42 plus hydrogen-rich saline treated animals. Hydrogen-rich saline (5 ml/kg, ...
LUNG - CANCER

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

Year Published: 2011

Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from ...
EAR - CANCER

Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress

Year Published: 2011

Cisplatin, an anticancer drug used extensively to treat a broad range of tumors, has strong ototoxic side effects induced by reactive oxygen species (ROS). Recently, it has been reported that hydrogen gas (H(2)) is a new antioxidant by selectively reducing hydroxyl radical, the most cytotoxic ROS. The present study was designed to investigate whether H(2) treatment is beneficial to ...
BRAIN - STROKE

Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ...

Year Published: 2011

Hydrogen gas is neuroprotective in cerebral ischemia animal models. In this study, we tested the neuroprotective effects of hydrogen saline, which is safe and easy to use clinically, in a rat model of middle cerebral artery occlusion (MCAO). Sprague-Dawley male rats weighting 250-280 g were divided into sham, MCAO plus hydrogen saline and MCAO groups, and subjected to 90-min ischemia followed by ...
EYE - CORNEAL INJURY

Hydrogen and N-Acetyl-L-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse Corneal ...

Year Published: 2011

To investigate the role of reactive oxygen species (ROS) as the prime initiators of the angiogenic response after alkali injury of the cornea and observe the effects of antioxidants in preventing angiogenesis. The corneal epithelia of SOD-1-deficient mice or wild-type (WT) mice were removed after application of 0.15 N NaOH to establish the animal model of alkali burn. ROS production was ...
EYE - RETINAL INJURY

Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress ...

Year Published: 2011

Retinal neovascularization or retinopathy is a proliferative disorder of the retinal capillaries and is the primary cause of blindness. Some studies have shown that oxidative stress plays an important role in hyperoxia-induced retinal neovascularization. Previous reports have indicated that hydrogen has a therapeutic, antioxidant activity by selectively reducing hydroxyl radicals. This study ...
BONE - ROS-SCAVENGING

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene ...

Year Published: 2011

Background: Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reaction in various biological models and clinical tests; however, its essential mechanisms remain unknown. H2 directly reacts with the strong reactive nitrogen species peroxynitrite (ONOO-) as well as hydroxyl radicals (•OH), but not with nitric oxide radical (NO•). We ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema ...

Year Published: 2012

Background: Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on ...
BRAIN - SEPSIS

Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats ...

Year Published: 2012

Background: Sepsis is associated with high morbidity and mortality, and survivors can present with cognitive dysfunction. The present study was performed to investigate the effects of hydrogen-rich saline (HRS) on oxidative stress in the brain, cognitive dysfunction, and mortality in a rat model of sepsis. Methods: A rat model of sepsis was induced by cecal ligation and puncture. Physiologic ...
BRAIN - BRAIN INJURY

Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in ...

Year Published: 2012

Hydrogen gas has been demonstrated to neutralize free radicals and reduce oxidative stress recently. Our objective was to determine the therapeutic effect of H2 inhalation and its antioxidative activity on early brain injury after subarachnoid hemorrhage. Controlled in vivo laboratory study. Animal research laboratory. One hundred thirty-seven adult male Sprague-Dawley rats weighing 280-350 g. ...
HEART - HIGH BLOOD PRESSURE

Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular ...

Year Published: 2012

In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. In the current study, we explored the effect of chronic treatment with ...
WHOLE BODY - DIABETES

Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model ...

Year Published: 2012

Background: Molecular hydrogen, as a novel antioxidant, has been proven effective in treating many diseases. This study aimed to evaluate the therapeutic effects of hydrogen saturated saline in treatment of a rat model of diabetes mellitus and a rat model of insulin resistant. Methods: A rat diabetes mellitus model was established by feeding a high fat/high carbohydrate diet followed by injection ...
PANCREAS - PANCREATITIS

Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute ...

Year Published: 2012

Currently, little evidence exists to support whether the therapeutic approaches for treating ordinary acute pancreatitis (AP) are effective in trauma-induced pancreatitis. Hydrogen-rich (H2) saline is an antioxidant treatment capable of ameliorating the severity of L-arginine-induced AP. In this study, we attempted to validate its protective role against traumatic pancreatitis (TP). A previously ...
BRAIN - STROKE

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via ...

Year Published: 2012

Hydrogen gas (H(2)) as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable for clinical application. The present study was designed to investigate whether HS can offer a neuroprotective effect in a rat model of permanent focal cerebral ischemia and what mechanism(s) ...
WHOLE BODY - EXCERCISE

Effects of ionized alkali water intake on oxidative stress and its related gene expression induced ...

Year Published: 2012

The purpose of this study was to investigate the effects of ionized alkali water supplement on oxidative stress and proinflammatory cytokines in highly trained high school and college track athletes (n=18). In an single group and cross-over design, all subjects consumed tap water and ionized alkali water for 2 weeks in a random order, and they underwent an acute and exhaustive treadmill running at ...
BRAIN - TRAUMATIC BRAIN INJURY

Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing ...

Year Published: 2012

Background: Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS. Our recent study shows that H(2) inhalation is beneficial to traumatic brain injury (TBI) via reducing oxidative stress. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable ...
BONE - RHEUMATOID ARTHRITIS

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress ...

Year Published: 2012

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing ...
BRAIN - BRAIN INJURY

Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via ...

Year Published: 2012

To investigate the effects of inhalation of hydrogen gas on cognitive impairment induced by transient cerebral ischemia and its potential mechanism. Two-vessel occlusion rat model was used to produce 10-minute transient global cerebral ischemia. One hundred and twenty male Wistar rats were randomly divided into sham, sham+H(2), ischemia, and ischemia+H(2) groups (n = 30 each group). Inhalation of ...