Search

Studies Found: 256

BRAIN - BRAIN INJURY

Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic ...

Year Published: 2016

Hypoxic-ischemic encephalopathy (HIE) is the major consequence of perinatal asphyxia (PA) in term neonates. Although the newborn piglet is an accepted large animal PA/HIE model, there is no consensus on PA-induction methodology to produce clinically relevant HIE. We aimed to create and to characterize a novel PA model faithfully reproducing all features of asphyxiation including severe hypercapnia ...
BRAIN - BRAIN INJURY

Hydrogen does not Exert Neuroprotective Effects or Improve Functional Outcomes in Rats After ...

Year Published: 2016

Aim: Increasing evidence suggests that reactive oxygen species damage the blood-brain barrier and increase brain edema after intracerebral hemorrhage (ICH). Recently, strong clinical and experimental evidence has shown that hydrogen has potent protective cellular effects in various diseases. However, the effect of hydrogen on ICH remains unclear. The present study investigates whether hydrogen has ...
HEART - CARDIAC ARREST

Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – ...

Year Published: 2016

Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.Methods and Results:Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological ...

Year Published: 2016

Background: Non-shockable rhythms represent an increasing proportion of reported cases of out-of-hospital cardiac arrest but with an associated poor prognosis. In the present study, we investigated the effects of hydrogen inhalation on cardiac and neurological function after cardiopulmonary resuscitation and compared the therapeutic benefit with hypothermia in an asphyxial rat model of cardiac ...
EYE - RETINAL INJURY

Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of ...

Year Published: 2016

Retinal ischemia/reperfusion (I/R) injury plays a crucial role in the pathophysiology of various ocular diseases. Intraperitoneal injection or ocular instillation with hydrogen (H2)-rich saline was recently shown to be neuroprotective in the retina due to its anti-oxidative and anti-inflammatory effects. Our study aims to explore whether postconditioning with inhaled H2 can protect retinal ...
BRAIN - BRAIN INJURY

The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia ...

Year Published: 2016

Background/aim: The aim of this study was to investigate whether a hydrogen administration can produce neuroprotective effects after brain ischemia reperfusion in rats. Materials and methods: A brain ischemia reperfusion injury was induced by a 2-h left middle cerebral artery occlusion (MCAO) using an intraluminal filament, followed by 46 h of reperfusion. A hydrogen-rich saline (1 mL/kg body ...
BRAIN - BRAIN INJURY

Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy

Year Published: 2016

This study retrospectively analyzed the efficacy of hydrogen water in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on serum neuron-specific enolase (NSE), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels. Forty newborns with HIE who received treatment from April 2014 to April 2015 were divided into a conventional care group and a hydrogen water ...
BRAIN - PARKINSON'S DISEASE

A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: ...

Year Published: 2016

Background: Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score of Parkinson's disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. Methods: Changes in the total UPDRS scores ...
BRAIN - STRESS RESILIENCE

Effects of hydrogen-rich water on depressive-like behavior in mice

Year Published: 2016

Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinflammatory cytokine interleukin-1β (IL-1β) and oxidative stress biomarkers in the periphery or central nervous system (CNS). Recent studies show that hydrogen selectively reduces cytotoxic ...
BRAIN - MULTIPLE SCLEROSIS

Hydrogen-rich water improves neurological functional recovery in experimental autoimmune ...

Year Published: 2016

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Molecular hydrogen (H2) has been reported to exhibit anti-oxidant, anti-apoptotic, anti-inflammatory, ...
BRAIN - NEUROPATHIC PAIN

Abstract: Consumption of hydrogen water prevents the occurrence of neuropathic pain in mice

Year Published: 2015

No abstract available
BRAIN - NEUROPATHIC PAIN

H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat ...

Year Published: 2015

Neuropathic pain (NP) is characterized by persistent pain, tactile allodynia, or hyperalgesia. Peripheral nerve injury contributes to rapid progress of inflammatory response and simultaneously generates neuropathic pain. Hydrogen (H2) has anti-inflammation, anti-apoptosis, and anti-oxidative stress effects. Therefore, we hypothesized that H2 treatment could alleviate allodynic and hyperalgesic ...
BRAIN - BRAIN INJURY

Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering ...

Year Published: 2015

Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate whether HRW could moderate parvalbumin and hippocalcin expression during ischemic ...
BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a ...

Year Published: 2015

Amyloid β (Aβ) peptides are identified in cause of neurodegenerative diseases such as Alzheimer's disease (AD). Previous evidence suggests Aβ-induced neurotoxicity is linked to the stimulation of reactive oxygen species (ROS) production. The accumulation of Aβ-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be ...
EYE - RETINAL INJURY

Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and ...

Year Published: 2015

Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia‑reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen‑rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP‑1 activation. RIR was induced by ...
PREGNANCY - NEUROPROTECTION

Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury

Year Published: 2015

Fetal brain injury is often related to prenatal inflammation; however, there is a lack of effective therapy. Recently, molecular hydrogen (H2), a specific antioxidant to hydroxyl radical and peroxynitrite, has been reported to have anti-inflammatory properties. The aim of this study was to investigate whether maternal H2 administration could protect the fetal brain against inflammation. Pregnant ...
BRAIN - BRAIN INJURY

Protective effect of molecular hydrogen against white matter ischemic injury

Year Published: 2015

The central nervous system (CNS) white matter (WM) ischemia is an important clinical problem and may produce injury, in part, by reactive oxygen species (ROS)-induced mitochondrial dysfunction. Using the mouse optic nerve (MON) WM model, we tested whether hydrogen (H2) in drinking water reduced functional WM ischemic injury. Functional integrity of MON was determined by quantitatively monitoring ...
BRAIN - BRAIN INJURY

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by ...

Year Published: 2015

Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH, involved to anti-oxidative and anti-apoptotic effect. We have previously ...
SPINE - SURGERY/TRANSPLANTATION

Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement ...

Year Published: 2015

Background: Hyperalgesia is one of the negative consequences following intraoperative analgesia with remifentanil. Peroxynitrite is a critical determinant in nociceptive process. Peroxynitrite inactivates iron-sulfur cluster that results in mitochondrial dysfunction and the release of iron, leading to mitochondrial iron accumulation. Iron accumulation mediated by divalent metal transporter 1 ...
BRAIN - STROKE

Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in ...

Year Published: 2015

Enhanced oxidative stress occurs in spontaneously hypertensive stroke-prone rats (SHRSP), and is important in blood-brain barrier (BBB) disruption. Hydrogen can exert potent protective cellular effects via reduction in oxidative stress in various diseases. The present study investigated whether long-term hydrogen treatment can improve neurological function outcome in the SHRSP model, and the ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats

Year Published: 2015

Inflammation and oxidative stress are the two major causes of apoptosis after traumatic brain injury (TBI). Most previous studies of the neuroprotective effects of hydrogen-rich water on TBI primarily focused on antioxidant effects. The present study investigated whether hydrogen-rich water (HRW) could attenuate brain damage and inflammation after traumatic brain injury in rats. A TBI model was ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing ...

Year Published: 2015

Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that has been used in the operations involving the aortic arch and brain aneurysm for decades. We previous showed that DHCA treated rats developed a significant oxidative stress and apoptosis in neurons. We here intend to investigate the protective the effect of hydrogen against oxidative stress-induced cell injury and ...
EYE - RETINAL INJURY

Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived ...

Year Published: 2015

Background Oxidative and nitrative processes have an important role in the pathogenesis of glaucomatous neurodegeneration. Oxidative stress occurs when cellular production of reactive oxygen species outweighs the protective capacity of antioxidant defences. Reactive oxygen species are generated as by-products of cellular metabolism, primarily in the mitochondria. Herein, we present a novel ...
BRAIN - DIABETES

Protective effect of hydrogen‑rich medium against high glucose‑induced apoptosis of Schwann ...

Year Published: 2015

Diabetic peripheral neuropathy (DPN) is considered to be one of the most prevalent and life threatening microvascular diabetic complications. DPN affects up to 50% of patients with diabetes mellitus and there are currently no efficacious therapeutic strategies available for its treatment. Previous studies have reported that oxidative stress and poly(ADP‑ribose) polymerase‑1 (PARP‑1) may be ...
BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with ...

Year Published: 2015

Objective: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI). Methods: Ninety healthy male Sprague-Dawley (SD) rats were randomly divided into sham operation group, TBI group and hydrogen rich water treatment group (HW group), with 30 rats in each group. TBI model ...