Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – First-in-Human Pilot Study

Hiroshi Morisaki, Joe Yoshizawa, Kei Hayashida, Keiichi Fukuda, Masaru Suzuki, Motoaki Sano, Shigeo Ohta, Shingo Hori, Takayuki Shibusawa, Takeshi Suzuki, Tomoyoshi Tamura, Yosuke Kobayashi

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DOI: 10.1253/circj.CJ-16-0127 DOI is the universal ID for this study.

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Background: Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.Methods and

Results:Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome. Conclusions: HI in combination with TTM is a feasible therapy for patients with PCAS.

Publish Year 2016
Country Japan
Rank Positive
Journal Circulation Journal
Primary Topic Heart
Secondary TopicCardiac Arrest
Model Human
Tertiary TopicHydrogen Safety
Vehicle Gas
pH N/A
Application Inhalation