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Studies Found: 1335

KIDNEY - CANCER

Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity ...

Year Published: 2013

The aim of this work was to test whether consumption with hydrogen-rich water (HW) alleviated renal injury and inhibited early tumor promotional events in Ferric nitrilotriacetate (Fe-NTA)-treated rats. Rats were injected with Fe-NTA solution (7.5mg Fe/kg body weight) intraperitoneally to induce renal injury and simultaneously treated with HW (1.3 ± 0.2mg/l). We found that consumption with HW ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS

Hydrogen as a treatment candidate for non-alcoholic steatohepatitis

Year Published: 2013

No abstract available
LUNG - SURGERY/TRANSPLANTATION

Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway

Year Published: 2013

Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and ...
TESTES - RADIOPROTECTION

Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats

Year Published: 2013

The aim of this study was to investigate the possible protective role of hydrogen‐rich saline solution (HRSS) and WR‐2721 on the testicular damage induced by irradiation. Sprague‐Dawley rats were randomly divided into four groups. Group I served as control group. Rats in group II were exposed to the irradiation. The animals in group III and IV were injected intraperitoneally with HRSS (5 ...
WHOLE BODY - OBESITY

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 ...

Year Published: 2013

Background: There is accumulating evidence that obesity is closely associated with an impaired free fatty acid metabolism as well as with insulin resistance and inflammation. Excessive fatty acid uptake mediated by fatty acid translocase CD36 plays an important role in hepatic steatosis. Molecular hydrogen has been shown to attenuate oxidative stress and improve lipid, glucose and energy ...
HEART - DIABETES

Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ...

Year Published: 2013

The purpose of the present study was to determine whether using hydrogen-rich medium (HRM) to increase hydrogen levels in endothelial cells (ECs) protects ECs from apoptosis induced by advanced glycation end products (AGEs). The thoracic aorta was removed from 2-3-year-old Sprague-Dawley rats, and ECs were isolated and cultured. After culturing ECs in the presence of AGEs and/or with HRM for 24 h, ...
SKIN - RADIOPROTECTION

The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice

Year Published: 2013

Exposure to UVB radiation induced skin damage that results to increase risk of skin cancer. Despite the clinical importance of skin-induced damage, antioxidants imposed limited therapeutic success. Hydrogen molecule (H2) has been known as a safe antioxidant in the prevention and therapeutic approach towards several diseases. Drinking hydrogen reduced water (HRW), inhalation of hydrogen gas, and ...
WHOLE BODY - OBESITY

Anti-obesity effect of alkaline reduced water in high fat-fed obese mice

Year Published: 2013

Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, ...
BRAIN - CARDIAC ARREST

The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest

Year Published: 2013

Objective: The purpose of this study was to investigate the neuroprotective effects of intraperitoneal injection of hydrogen (H2) in rabbits with cardiac arrest (CA). Methods: A rabbit model of CA was established by the delivery of alternating current between the esophagus and chest wall to induce ventricular fibrillation. Before CA, the animals were randomly divided into four groups: a sham group ...
SKIN - DERMATITIS

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae ...

Year Published: 2013

Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we ...
HEART - HIGH BLOOD PRESSURE

Protection of oral hydrogen water as an antioxidant on pulmonary hypertension

Year Published: 2013

This study aimed to explore the protective effect of hydrogen as an antioxidant on monocrotaline (MCT)-induced pulmonary hypertension (PH). Forty-eight SD rats were equally randomized into four groups: SHAM group, MCT group, MCT+Oral-H2 group and MCT+Inj-H2 group. The results showed that the mean pulmonary arterial pressure, right ventricle weight and right ventricular hypertrophy index in MCT ...
INTESTINE - INFLAMMATORY BOWEL DISEASE

Protective effects of hydrogen-rich saline on ulcerative colitis rat model

Year Published: 2013

Background: Ulcerative colitis (UC) is associated with enhanced production of reactive oxygen species and altered angiogenesis. Molecular hydrogen has been documented as a novel antioxidant to treat various reactive oxygen species-related diseases. The present study aimed to investigate the effects of hydrogen on UC using a rat model. Materials and methods: UC in rats was induced with ...
EYE - DIABETES

Hydrogen-Rich Saline Prevents Early Neurovascular Dysfunction Resulting from Inhibition of Oxidative ...

Year Published: 2013

Purpose: Diabetic retinopathy (DR) is characterized by increased oxidative and nitrosative stress, both of which lead to neurotoxicity and vascular permeability. Previous studies on a variety of organs indicate that hydrogen-rich saline not only has considerable antioxidant and anti-inflammatory properties, but also suppresses oxidative stress-induced injury. In the present study, we assessed the ...
BONE - OSTEOPOROSIS

Hydrogen water consumption prevents osteopenia in ovariectomized rats

Year Published: 2013

Background and purpose: Accumulating evidence indicates an important role of oxidative stress in the progression of osteoporosis. Recently, it was demonstrated that hydrogen gas, as a novel antioxidant, could selectively reduce hydroxyl radicals and peroxynitrite anion to exert potent therapeutic antioxidant activity. The aim of the present work was to investigate the effect of hydrogen water (HW) ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia ...

Year Published: 2013

Hydrogen-rich saline has been reported to prevent neointimal hyperplasia induced by carotid balloon injury. The purpose of the present study was to further investigate the molecular mechanisms underlying this phenomenon. Daily injection of a hydrogen-rich saline solution (HRSS) in rats was employed to study the effect of hydrogen on balloon injury-induced neointimal hyperplasia and the ...
PENIS - DIABETES (TYPE II)

Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced ...

Year Published: 2013

Purpose: Hydrogen has antioxidative stress and anti-inflammatory effects. We investigated the effect of hydrogen on erectile dysfunction in streptozotocin induced diabetic rats. Materials and methods: Diabetes was induced in Sprague-Dawley® rats by a single intravenous injection of streptozotocin. Diabetic rats were then randomized to a diabetes mellitus group and to a diabetic group that ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress

Year Published: 2013

Background: Reactive oxygen species (ROS) are often associated with persistent pains such as neuropathic and inflammatory pain. Hydrogen gas can reduce ROS and alleviate cerebral, myocardial, and hepatic ischemia/reperfusion injuries. In the present study, we aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI). Methods: ...
INTESTINE - INFLAMMATORY BOWEL DISEASE

Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing ...

Year Published: 2013

Background: Molecular hydrogen (H2) is a potent antioxidant and able to protect organs from oxidative stress injuries. Orally administered lactulose, a potent H2 inducer, is digested by colon microflora and significantly increases H2 production, indicating its potential anti-inflammatory action. Objective: To evaluate the anti-inflammatory effects of lactulose on dextran sodium sulfate ...
BONE - OSTEOPOROSIS

Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast

Year Published: 2013

Tumor necrosis factor-alpha (TNFα) plays a crucial role in inflammatory diseases such as rheumatoid arthritis and postmenopausal osteoporosis. Recently, it has been demonstrated that hydrogen gas, known as a novel antioxidant, can exert therapeutic anti-inflammatory effect in many diseases. In this study, we investigated the effect of treatment with hydrogen molecule (H2) on TNFα-induced cell ...
WHOLE BODY - INFLAMMATION

Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW ...

Year Published: 2013

Background: Molecular hydrogen (H2) as a new medical gas has an anti-inflammatory effect. In the present study, we investigated whether heme oxygenase-1 (HO-1) contributes to the anti-inflammatory effect of H2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods: RAW 264.7 macrophages were stimulated by LPS (1 μg/mL) with presence or absence of different concentrations of H2. ...
WHOLE BODY - HEAT STRESS

Electrolysed reduced water decreases reactive oxygen species-induced oxidative damage to skeletal ...

Year Published: 2013

1. The present study was designed to achieve a reduction of reactive oxygen species (ROS)-induced oxidative damage to skeletal muscle and to improve the performance of broiler chickens exposed to chronic heat stress. 2. Chickens were given a control diet with normal drinking water, or diets supplemented with cashew nut shell liquid (CNSL) or grape seed extract (GSE), or a control diet with ...
KIDNEY - SURGERY/TRANSPLANTATION

Inhaled Hydrogen Gas Therapy for Prevention of Renal Ischemia/Reperfusion Injury in Rat Model

Year Published: 2013

Objective: We aimed to show the short- and long-term protective effects of inhaled hydrogen gas on renal ischemia/reperfusion (I/R) injury in a rat model. Material and Methods: Thirty Sprague-Dawley rats were randomly divided into 3 major experimental groups (Group 1, sham; Group 2, I/R; Group 3, hydrogen-I/R). Subsequently, Group 2 and 3 were divided into subgroups as early (E) and late (L) ...
WHOLE BODY - DIABETES (TYPE I)

Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into ...

Year Published: 2013

Hydrogen (H(2)) acts as a therapeutic antioxidant. However, there are few reports on H(2) function in other capacities in diabetes mellitus (DM). Therefore, in this study, we investigated the role of H(2) in glucose transport by studying cultured mouse C2C12 cells and human hepatoma Hep-G2 cells in vitro, in addition to three types of diabetic mice [Streptozotocin (STZ)-induced type 1 diabetic ...
SPLEEN - RADIOPROTECTION

Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction

Year Published: 2014

Recent studies showed that hydrogen can be used as an effective radioprotective agent through scavenging free radicals. This study was undertaken to evaluate the radioprotective effects of hydrogen on immune system in mice. H2 was dissolved in physiological saline using an apparatus produced by our department. Spleen index and histological analysis were used to evaluate the splenic structural ...
PREGNANCY - PREECLAMPSIA

Regulative effect of hydrogen on oxidative stress level of placental ischemia-reperfusion cell model ...

Year Published: 2014

Objective To investigate the effects of hydrogen on cell protection of placental ischemia-reperfusion cell model of preeclampsia and its possible mechanism. Methods JAR cells cultured in vitro were divided into five groups, i.e. the blank control group, saturated hydrogen group under normal oxygen cultivation conditions (normal oxygen+H2 group), ischemia-reperfusion model group (model group), ...