New Hydrogen Ion Theory Could Transform Breast Cancer Treatment
- Authors
- Salvador Harguindey, Kahlid Alfarouk, Julian Polo Orozco, Stefano Fais, Jesus Devesa
- Journal
- International Journal of Molecular Sciences
- Year
- 2020
- DOI
- 10.3390/ijms21207475
- Study Type
- clinical
- Peer Reviewed
- Yes
- Country
- Spain
- Health Condition
- Breast Cancer
- Body System
- Reproductive System
TL;DR
Scientists think they've found a major clue to fighting breast cancer: understanding how acid levels inside cancer cells work. If they're right, treating the acid balance in tumors could help fight almost every type of breast cancer, which would be a game-changer because it offers one unified approach instead of separate treatments for different cancers.
Key Finding
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Summary
Scientists have developed a comprehensive theory suggesting that hydrogen ion (H+) dynamics and pH regulation are fundamental to breast cancer development and progression. This pH-centric approach aims to unify various aspects of cancer biology that were previously understood separately. The researchers propose that by targeting pH regulation with specific drugs, treatments could be effective across all types and stages of breast cancer. This theoretical framework builds on previous cancer metabolism research and suggests that controlling hydrogen ion levels could interfere with cancer's key survival mechanisms. While promising, this remains a conceptual model requiring experimental validation through clinical trials.
Abstract
A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspective, based upon the hydrogen ion (H+) dynamics of cancer, allows for the understanding and integration of the many dualisms, confusions, and paradoxes of the disease. The new H+-related, wide-ranging model can embrace, from a unique perspective, the many aspects of the disease and, at the same time, therapeutically interfere with most, if not all, of the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC reviewed here may be beneficial for all types and stages of the disease. In this vein, we have attempted a megasynthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide-ranging approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of the pH-related drugs that are available nowadays for the treatment of breast cancer is advanced.