Hydrogen Therapy Shows Promise for Multiple Diseases and Conditions
The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance
Research hubs: Cardiovascular System · Brain & Nervous System

- Evidence type
- Review or commentary
- Authors
- Brandon J Dixon, Jiping Tang, John H Zhang
- Journal
- Medical Gas Research
- Year
- 2013
- PMID
- 23680032
- Study Type
- clinical
- Delivery
- mixed
- Peer Reviewed
- Yes
- Cited by
- 119 (OpenAlex, as of November 2026)
- Country
- United States
TL;DR
Scientists found that hydrogen gas might be a powerful medicine because it can get inside our cells and fight inflammation and damage, which could help treat diseases like heart problems and cancer—and it barely has any side effects, but doctors still need to do more research to figure out the best ways to use it.
Key Finding
Molecular hydrogen can penetrate deep into cells, including crossing the blood-brain barrier and reaching mitochondria, where it may exert antioxidant, anti-inflammatory, and cell-protective effects across multiple disease categories.
Summary
This is a review article that summarizes existing research on molecular hydrogen as a potential medical treatment. The article explains that hydrogen can reach important parts of cells (like the mitochondria, which produces energy, and the nucleus, which contains DNA) and may help protect cells by reducing harmful inflammation and cell damage. Researchers have studied hydrogen for various diseases including heart disease, brain disease, cancer, and lung disease, and it appears to have few side effects.
Practical Takeaway
This is a review article summarizing existing research rather than a new study with original findings, so it does not provide new evidence about hydrogen water's effects in humans. While the article suggests hydrogen has therapeutic potential, most supporting research has been conducted in laboratory or animal studies, not in people. Anyone considering hydrogen water should recognize that clinical evidence in humans remains limited, and this review does not establish proven health benefits.
Abstract (excerpt)
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter…