Hydrogen Shows Promise as Versatile Medical Treatment for Multiple Diseases
The Clinical Application of Hydrogen as a Medical Treatment
Research hubs: Cardiovascular System

- Evidence type
- Review or commentary
- Authors
- Atsuyoshi Iida, Nobuyuki Nosaka, Tatsuya Yumoto, Emily Knaup, Hiromichi Naito, Chihiro Nishiyama, Yasuaki Yamakawa, Kohei Tsukahara, Michihisa Terado, Keiji Sato, Ugawa Toyomu, Atsunori Nakao
- Journal
- Acta Medica Okayama
- Year
- 2016
- PMID
- 27777424
- Study Type
- clinical
- Delivery
- mixed
- Outcome
- positive
- Peer Reviewed
- Yes
- Cited by
- 69 (OpenAlex, as of November 2026)
- Country
- Japan
TL;DR
Scientists found that hydrogen gas might be a useful medicine for treating different diseases, especially ones caused by damage from lack of blood flow to organs. The cool part is that hydrogen can be given to patients in many different ways—you can breathe it in, drink it in special water, inject it, or apply it directly to the problem area—which makes it super flexible as a potential treatment.
Key Finding
Molecular hydrogen shows potential therapeutic effects across multiple disease models through various delivery methods, with particular promise in treating ischemia-reperfusion injury by reducing oxidative stress.
Summary
This review article examines research on molecular hydrogen as a potential medical treatment. Scientists have found that hydrogen may help protect against various types of tissue damage, particularly injury that occurs when blood flow is restored after being cut off (called ischemia-reperfusion injury). Hydrogen can be delivered to the body in multiple ways—as a gas you breathe, as hydrogen-rich water you drink, through injection, or applied directly to affected areas—and early research suggests it may work by reducing harmful chemical reactions in cells.
Practical Takeaway
This is a review of existing research rather than a new study, so it does not provide new evidence about hydrogen water's effects in humans. The authors note that hydrogen research is still developing and that clinical applications remain to be established. Anyone considering hydrogen water should be aware that most evidence to date comes from laboratory and animal studies, not human trials.
Abstract (excerpt)
In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas…